Nebulized inhalation drug delivery: clinical applications and advancements in research DOI

Ruyi Yan,

Chang Zou,

Xiaohang Yang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(3), P. 821 - 843

Published: Nov. 27, 2024

Nebulized inhalation is a non-invasive drug delivery method with fast onset, low dosage, and fewer side effects. This review covers its principles, devices, clinical applications, future trends in respiratory systemic diseases.

Language: Английский

Recent approaches in nanotoxicity assessment for drug delivery applications: Challenges and prospects DOI Creative Commons
J. B. Thomas, Vinay Kumar, Neha Sharma

et al.

Medicine in Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100204 - 100204

Published: Feb. 1, 2025

Language: Английский

Citations

2
Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives DOI
Wenhao Wang, Ziqiao Zhong, Zhengwei Huang

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(6), P. 2820 - 2833

Published: Jan. 1, 2024

In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.

Language: Английский

Citations

10
Inhalable iron redox cycling powered nanoreactor for amplified ferroptosis-apoptosis synergetic therapy of lung cancer DOI

Linjing Wu,

Wenhao Wang,

Mengqin Guo

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(6), P. 5435 - 5451

Published: Feb. 1, 2024

Language: Английский

Citations

5
A novel therapeutic outlook: Classification, applications and challenges of inhalable micron/nanoparticle drug delivery systems in lung cancer (Review) DOI Creative Commons

Lixin Xie,

Daihan Xie,

Zhefei Du

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(4)

Published: Feb. 21, 2024

Lung cancer represents a marked global public health concern. Despite existing treatment modalities, the average 5‑year survival rate for patients with lung is only ~20%. As there are numerous adverse effects of systemic administration routes, an urgent need to develop novel therapeutic strategy tailored specifically cancer. Non‑invasive aerosol inhalation, as route drug administration, holds unique advantages in context respiratory diseases. Nanoscale materials have extensive applications field biomedical research recent years. The present study provides comprehensive review classification, summarized according clinical modalities and challenges associated inhalable micron/nanoparticle delivery systems (DDSs) Achieving localized preclinical models through inhalation deemed feasible. However, further required substantiate efficacy long‑term safety DDSs management

Language: Английский

Citations

5
Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression DOI Creative Commons

Rumeng Pan,

Rongli Wang,

Feiyan Cheng

et al.

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 11, 2024

Abstract Background Premature ovarian failure (POF) caused by cisplatin is a severe and intractable sequela for young women with cancer who received chemotherapy. Cisplatin causes the dysfunction of granulosa cells mainly leads to but not limited its apoptosis autophagy. Ferroptosis has been also reported participate, while little known about it. Our previous experiment demonstrated that endometrial stem (EnSCs) can repair cisplatin-injured cells. However, it still unclear whether EnSCs play role acting on ferroptosis. Methods Western blotting quantitative reverse-transcription polymerase chain reaction (qRT-PCR) were applied detect expression levels ferroptosis-related genes. CCK-8 5-Ethynyl-2’-deoxyuridine (EdU) assays used evaluate cell viability. Transmission electron microscopy (TEM) was performed ferroptosis in morphology. And extent assessed ROS, GPx, GSSG MDA indicators. In vivo, morphology presented HE staining protein tissue detected immunohistochemistry. Results results showed could occur inhibitor ferrostatin-1 (Fer-1) partly restored viability mitigated damage inhibiting Moreover, potential be markedly blocked ML385. Conclusion study induce cells, inhibit thus exert effects cisplatin-induced injury model both vivo vitro. Meanwhile, Nrf2 validated participate this regulatory process played an essential role.

Language: Английский

Citations

4
“All-in-one” metal polyphenol network nanocapsules integrated microneedle patches for lipophagy fueled ferroptosis-mediated multimodal therapy DOI
Wenhao Wang, Ziqiao Zhong, Siyuan Peng

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 599 - 616

Published: July 31, 2024

Language: Английский

Citations

4
Hyaluronic Acid Based Functionalization of Nanodelivery Systems: A Promising Strategy for CD44-Receptors-Mediated Targeted Therapy of Lung Cancer DOI
Zahid Hussain,

Asma Hamzeh Akbari,

Sali Husam Barbuor

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106183 - 106183

Published: Sept. 11, 2024

Language: Английский

Citations

4
Revolutionizing Lung Cancer Treatment with Smart Pulmonary Drug Delivery Nanosystems DOI

Osman Gamal,

Abdullah T. Agamey,

Zeinab A. Mohamed

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106158 - 106158

Published: Sept. 6, 2024

Language: Английский

Citations

3
A Pilot Study Exploiting the Industrialization Potential of Solid Lipid Nanoparticle-Based Metered-Dose Inhalers DOI Creative Commons
Lei Shu,

Wenhua Wang,

Chon-iong Ng

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 866 - 866

Published: March 7, 2023

Background: Delivery of inhalable nanoparticles through metered-dose inhalers (MDI) is a promising approach to treat lung disease such as asthma and chronic obstructive pulmonary disease. Nanocoating the helps in stability cellular uptake enhancement but complicates production process. Thus, it meaningful accelerate translation process MDI encapsulating with nanocoating structure. Methods: In this study, solid lipid (SLN) are selected model nanoparticle system. An established reverse microemulsion strategy was utilized explore industrialization potential SLN-based MDI. Three categories functions stabilization (by Poloxamer 188, encoded SLN(0)), cetyltrimethylammonium bromide, SLN(+)), targetability hyaluronic acid, SLN(−)) were constructed upon SLN, whose particle size distribution zeta-potential characterized. Subsequently, SLN loaded into MDI, evaluated for processing reliability, physicochemical nature, formulation stability, biocompatibility. Results: The results elucidated that three types successfully fabricated good reproducibility stability. Regarding safety, SLN(0) SLN(−) showed negligible cytotoxicity on level. Conclusions: This work serves pilot study scale-up could be useful future development nanoparticles.

Language: Английский

Citations

7
Fibroin nanodisruptor with Ferroptosis-Autophagy synergism is potent for lung cancer treatment DOI
Lei Shu, Peili Luo, Qingxin Chen

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 664, P. 124582 - 124582

Published: Aug. 12, 2024

Language: Английский

Citations

2