Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(3), P. 425 - 446
Published: Sept. 1, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(42)
Published: June 8, 2024
The delayed healing of infected wounds can be attributed to the increased production reactive oxygen species (ROS) and consequent damages vascellum tissue, resulting in a hypoxic wound environment that further exacerbates inflammation. Current clinical treatments including hyperbaric therapy antibiotic treatment fail provide sustained oxygenation drug-free resistance infection. To propose dynamic regulation strategy, this study develops composite hydrogel with ROS-scavenging system oxygen-releasing microspheres dressing. itself reduces cellular damage by removing ROS derived from immune cells. Simultaneously, release improves cell survival migration environments, promoting angiogenesis collagen regeneration. combination scavenging enables dressing achieve anti-infection through activating modulation, inhibiting secretion pro-inflammatory cytokines interleukin-6, tissue regeneration both acute rat skins. Thus, proposed work shows great potential for redox accelerates without drugs.
Language: Английский
Citations
5
Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 61, P. 100793 - 100793
Published: July 1, 2024
This review provides a comprehensive overview of the advancements and potential applications calcium peroxide nanoparticles (CaO2 NPs) in combating bacterial infections. With rise antibiotic resistance posing significant global health threat, alternative antibacterial agents like CaO2 NPs have garnered increasing attention. The begins by discussing synthesis functionalization NPs, highlighting recent developments nanoparticle engineering techniques. Subsequently, it explores intricate mechanisms emphasizing their ability to generate reactive oxygen species disrupt biofilms. Evaluation NPs' efficacy against broad spectrum pathogens, coupled with discussions on various fields including biomedical environmental remediation, underscores promising role as effective agents. also addresses challenges such stability biocompatibility, proposes future research directions fully exploit therapeutic NPs. Overall, this consolidates current knowledge advocates for continued exploration
Language: Английский
Citations
5
Surface and Coatings Technology, Journal Year: 2025, Volume and Issue: unknown, P. 131814 - 131814
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 11, 2025
Optimizing the immune microenvironment is essential for successful implant osseointegration. In this study, four different nano/microstructures were fabricated on polyetheretherketone (PEEK) substrates by varying agitation speed during sulfonation to influence osteoimmunomodulation and integration. The results indicate that with minimal dimensions (SP450) inhibit actin polymerization reducing calcium influx through PIEZO1, activating anti-inflammatory M2 macrophage phenotype. Among tested specimens, SP450 exhibited lowest expression levels of tumor necrosis factor-α interleukin-1β while releasing highest factors, including interleukin-4 interleukin-10. This optimized environment promotes osteogenesis MC3T3-E1 pre-osteoblasts enhances osseointegration PEEK implants. Transcriptomic analysis validation experiment further revealed inhibits osteoclastic differentiation down-regulating transforming growth factor-β2 suppressing NF-κB signaling pathway. These findings suggest manipulating surface topography implants an effective strategy enhancing promising clinical applications.
Language: Английский
Citations
0
Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(3), P. 425 - 446
Published: Sept. 1, 2024
Language: Английский
Citations
3