A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma DOI Creative Commons
Guo Chen, Rui Dou,

Linbang Wang

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Current advances in nanozyme-based nanodynamic therapies for cancer DOI
Xiangyang Zhou,

Shuaipeng Feng,

Qingqing Xu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

5
CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy DOI Creative Commons
Xiaoyu Wu,

Zijun Bai,

Hui Wang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 4059 - 4072

Published: June 5, 2024

Copper-based nanomaterials demonstrate promising potential in cancer therapy. Cu

Language: Английский

Citations

4
Copper(II) Complexes of Pyrazolopyrimidine Derivatives as Anticancer Agents with Enhanced Chemodynamic Therapy through Bimodal Apoptosis and Ferroptosis DOI
Kun Yang, Qian Chen, Juan Chen

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

We reported 10 new copper(II) complexes 1–10 with pyrazolopyrimidine derivatives as ligands. Complexes 2 and 4 reacted glutathione (GSH) in cells through Fenton-like reaction to generate highly toxic hydroxyl radical (·OH) for chemodynamic therapy (CDT), reduced endogenous peroxidase (GPX4) induce ferroptosis. In addition, these effectively caused mitochondrial dysfunction induced apoptosis autophagy tumor cells. Furthermore, inhibited the bladder cancer cell growth a xenograft model. This study presents that can significantly death by enhanced CDT bimodal ferroptosis, providing promising approach therapy.

Language: Английский

Citations

0
Intrauterine Perfusion of Versatile Nanotherapeutics for Revolutionizing Sono‐Chemotherapeutic Treatment of Orthotopic Choriocarcinoma DOI
Haoyi Zhao, Runqing Li, Hui Yu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Choriocarcinoma (CC) is a malignant solid tumor caused by abnormal differentiation of placental trophoblast cells. Clinical treatment mainly based on systemic intravenous chemotherapy, which faces multi therapeutic challenges. In this study, we pioneered the intrauterine perfusion route to treat orthotopic choriocarcinoma and achieved precise targeting effect combined with sonodynamic therapy (SDT). Our research meticulously developed an innovative biomimetic drug delivery system, designated as HIC@M nanoparticles (HIC@M NPs). This system involved incorporation cisplatin (CDDP) indocyanine green (ICG) onto hydrazide‐modified hyaluronic acid (HHA), followed encapsulation within cancer cell membrane. The prepared NPs could deplete GSH, generate large amounts reactive oxygen species (ROS), sensitize CDDP for higher efficiency. vivo results demonstrated that collaborative application SDT optimal efficacy while concurrently minimizing adverse effects. By depleting GSH generating ROS at site, not only modified microenvironment improve effectiveness mitigated resistance but also induced apoptosis ferroptosis activating p53 signaling pathway. conclusion, culminates in comprehensive anti‐tumor strategy choriocarcinoma.

Language: Английский

Citations

0
Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells DOI Creative Commons
Hui Yu,

Xinyi He,

Xiaoya Gu

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(1), P. 640 - 649

Published: Jan. 1, 2024

Carbon-coated selenium (C–Se) nanoparticles were prepared to perform roles in photothermal therapy on choriocarcinoma cells by inducing ROS generation and apoptosis under near-infrared irradiation.

Language: Английский

Citations

2
A DNA damage-amplifying nanoagent for cancer treatment via two-way regulation of redox dyshomeostasis and downregulation of tetrahydrofolate DOI
Yi Wang,

Zelong Chen,

Xingwang An

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134276 - 134276

Published: Oct. 1, 2024

Language: Английский

Citations

2
Additive application for modulating physicochemical properties and antitumor effects of CaCO3 nanodelivery systems DOI
Yue Sun, Xiaorong Yang,

Zehua Wu

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106080 - 106080

Published: Aug. 23, 2024

Language: Английский

Citations

1
Potential Exploration of Biocompatible Carbon-Coated MoSe2 Nanoparticles for Exploration of the Photothermal Potential in the Treatment of Human Choriocarcinoma DOI Creative Commons
Hui Yu,

Xinyi He,

Jinmeng Yao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2359 - 2375

Published: March 1, 2024

Background: Molybdenum diselenide (MoSe 2 ), as a nano near-infrared absorber, has been widely studied in the field of photothermal therapy cancer.However, there is little research on its application treatment human choriocarcinoma.Methods and Results: In this paper, new type carbon-coated MoSe (MEC) nanoparticles was prepared by one-step hydrothermal method.The chemical characterization including SEM, TEM, EDS, XRD, FT-IR, TGA, Roman, XPS showed that MEC successfully synthesized.MEC exhibited high conversion efficiency (50.97%) extraordinary stability under laser irradiation.The cell experiment results had good biocompatibility normal cells while significant effect choriocarcinoma (JEG-3) cells, achieving anticancer effect.The level reactive oxygen species (ROS) JEG-3 significantly increased combination nearinfrared radiation.MEC could induce apoptosis with radiation.Finally, transcriptomic analysis verified combined radiation inhibit DNA replication apoptosis, thus improving therapeutic choriocarcinoma.Conclusion: exert an excellent may become important candidate drug for choriocarcinoma.

Language: Английский

Citations

0
Exploring Amanita muscaria (L.) Lam.: Cytotoxic, proapoptotic and antiferroptotic effect of acetone extract on JAR choriocarcinoma cell line DOI Creative Commons
Sara Milojević, Danijela Nikodijević, Milena Milutinović

et al.

Kragujevac Journal of Science, Journal Year: 2024, Volume and Issue: 46(1), P. 121 - 135

Published: Jan. 1, 2024

The pharmaceutical industry has long focused on nature-derived biologically active compounds to address challenges in cancer treatment, particularly overcoming cell resistance programmed death, including apoptosis and ferroptosis. cytotoxic effect of Amanita muscaria acetone extract the JAR choriocarcinoma line was evaluated using MTT assay analysis two selected death pathways. putative ferroptotic by measuring main redox parameters relative expression key antiferroptotic genes. Our findings indicate that IC50 A. 168.96 (after 24 h) 43.85 72 mg/mL, inducing mainly a proapoptotic cells. also demonstrated an effect. Both effects were achieved regardless induction oxidative stress._ This is first report indicating

Language: Английский

Citations

0
A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma DOI Creative Commons
Guo Chen, Rui Dou,

Linbang Wang

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Citations

0