Polyphenol‐Copper Derived Self‐Cascade Nanozyme Hydrogel in Boosting Oxygenation and Robust Revascularization for Tissue Regeneration

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: April 25, 2024

Abstract The regeneration of hypoxia‐impaired chronic tissue defects has long been challenging, mainly due to the inefficiency oxygenation and limited biological activity existing oxygen delivery systems in regulating dynamic process. Herein, a novel polyphenol‐copper coordination strategy fabricate bioactive superoxide dismutase‐catalase self‐cascade nanozymes (SalB‐CuNCs) is reported, which can serve as an situ oxygenator induce angiogenesis simultaneously. copper‐phenolic hydroxyl structure SalB‐CuNCs plays critical role promoting enzyme‐like cascade reaction via catechol‐mediated Cu valence state transition substrate capture mechanism. Furthermore, after incorporating into Schiff base hydrogel (COC@SalB‐Cu), resulting system exhibits outstanding antioxidant robust effect mitigating hypoxic microenvironment. Benefiting from intrinsic angiogenic SalB copper, COC@SalB‐Cu more complete tube formation by up‐regulating expression level vascular endothelial growth factor (VEGF), platelet‐endothelial cell adhesion molecule‐1 (CD31), nitric oxide synthase (eNOS). In vivo experiments further demonstrate that significantly restore blood supply, leading fast regeneration. present holds enormous promise for treatment hypoxia‐related injury field regenerative medicine.

Language: Английский

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Gas Therapy: Generating, Delivery, and Biomedical Applications

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

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Design of a delivery vehicle chitosan-based self-assembling: controlled release, high hydrophobicity, and safe treatment of plant fungal diseases

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 19, 2024

Abstract Background Traditional pesticides are poorly water-soluble and suffer from low bioavailability. N -succinyl chitosan (NSCS) is a derivative, has been recently used to encapsulate hydrophobic drugs improve their However, it remains challenging synthesize of wide variety scale up the production in continuous manner. Results A synthetic method for preparing nanopesticides with polymer carrier was applied. The bioactive molecule BTL-11 loaded into hollow NSCS promote drug delivery, solubility anti-fungal activity. synthesized had well controlled sizes 606 nm encapsulation rate 80%. release kinetics, toxicity activity were further evaluated. inhibitory against Rhizoctonia solani ( R. ) tested vivo vitro. In trials revealed that excellent control efficiency cultivated rice leaf sheath 79.6 76.5%, respectively. By contrast, BTL-11@NSCS NPs, ability strongly released afforded significant efficiencies 85.9 81.1%. Those effects significantly better than agricultural fungicide azoxystrobin (51.5 66.5%). proposed mechanism validated by successfully predicting synthesis outcomes. Conclusions This study demonstrates promising biocompatible carrier, which can enhance efficacy pesticides, synergistically plant disease resistance, protect crop growth, be delivery more insoluble pesticides. Graphical

Language: Английский

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Facile preparation of self-healing hydrogels based on chitosan and PVA with the incorporation of curcumin-loaded micelles for wound dressings

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(2), P. 025021 - 025021

Published: Jan. 12, 2024

The increased demand for improved strategies wound healing has, in recent years, motivated the development of multifunctional hydrogels with favorable bio-compatibility and antibacterial properties. To this regard, current study presented design a novel self-healing composite hydrogel that could perform as dressing promotion healing. were composed polyvinyl alcohol (PVA), borax chitosan functionalized sialic acid (SA-CS) curcumin loaded pluronic F127 micelles. formed through boronic ester bond formation between PVA, SA-CS under physiological conditions demonstrated adjustable mechanical properties, gelation kinetics When incubating NIH3T3 cells, also good biocompatibility. These aspects offer promising foundation their prospective applications developing clinical materials

Language: Английский

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Calcium peroxide/lignocellulose composites for controlled oxygen release in water

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127696 - 127696

Published: April 1, 2025

Language: Английский

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Liposomal oxygen-generating hydrogel for enhancing cell survival under hypoxia condition

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 231, P. 113562 - 113562

Published: Sept. 18, 2023

Language: Английский

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Self-adaptive carbon nanozyme regulation of ROS balance for bacteria-infected wound therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 155904 - 155904

Published: Sept. 17, 2024

Language: Английский

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An injectable in situ-forming hydrogel with self-activating genipin-chitosan (GpCS) cross-linking and an O2/Ca2+ self-supplying capability for wound healing and rapid hemostasis

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 123051 - 123051

Published: Nov. 28, 2024

Language: Английский

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Enzymes in Addressing Hypoxia for Biomaterials Engineering

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(30)

Published: Aug. 25, 2024

Abstract Oxygen is essential for normal cellular functions. Hypoxia impacts various processes, such as metabolism, growth, proliferation, angiogenesis, metastasis, tumorigenesis, microbial infection, and immune response, mediated by hypoxia‐inducible factors (HIFs). contributes to the progression development of cancer, cardiovascular diseases, metabolic disorders, kidney infections. The potential alleviation hypoxia has been explored through enzymatic in situ decomposition hydrogen peroxide, leading generation oxygen. However, challenges limited stability restrict effectiveness enzymes catalase biomedical vivo applications. To overcome these limitations, targeted delivery proposed. This review offers a critical comparison i) current approaches enhance catalase; ii) structure, mechanism action, kinetics catalase‐like nanozymes.

Language: Английский

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