Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114338 - 114338
Published: Oct. 24, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
83
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 126 - 156
Published: March 2, 2024
Small extracellular vesicles (sEVs) are known to be secreted by a vast majority of cells. These sEVs, specifically exosomes, induce specific cell-to-cell interactions and can activate signaling pathways in recipient cells through fusion or interaction. nanovesicles possess several desirable properties, making them ideal for regenerative medicine nanomedicine applications. properties include exceptional stability, biocompatibility, wide biodistribution, minimal immunogenicity. However, the practical utilization particularly clinical settings at large scale, is hindered expensive procedures required their isolation, limited circulation lifetime, suboptimal targeting capacity. Despite these challenges, sEVs have demonstrated remarkable ability accommodate various cargoes found extensive applications biomedical sciences. To overcome limitations broaden potential applications, researchers should strive deepen understanding current loading, characterization techniques. Additionally, acquiring fundamental knowledge about origins employing state-of-the-art methodologies expand research scope. This review provides comprehensive overview exosome-based strategies diverse domains, encompassing cancer therapy, immunotherapy, biomarker Furthermore, we emphasize immense exosomes medicine.
Language: Английский
Citations
32
Small Methods, Journal Year: 2024, Volume and Issue: 8(8)
Published: Jan. 9, 2024
Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.
Language: Английский
Citations
19
Langmuir, Journal Year: 2024, Volume and Issue: 40(6), P. 3087 - 3094
Published: Jan. 29, 2024
Adhesive hydrogels are considered to be promising interfacial adhesive materials for various applications; however, their strength is significantly reduced when immersed in liquid environments (water and oil) due obstruction of the layer or swelling liquid, they could not always reused failure performance occurred. Herein, a graphite oxide/poly(vinyl alcohol) (GO/PVA) hydrogel with strong adhesion air under was developed by rationally regulating interactions water dimethyl sulfoxide (DMSO) binary system. The interaction between DMSO allowed GO/PVA on surface act as shield repel oil air, water, even oil, it also endowed obtained antiswelling property oil. Importantly, serve an advanced firmly bond different substrates interestingly, its dry wet repeatable recyclable. This work expected important addition field soft materials.
Language: Английский
Citations
4
Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 456 - 485
Published: March 19, 2025
Language: Английский
Citations
0
Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: unknown
Published: March 27, 2024
This study addresses a critical challenge in bioprinting for regenerative medicine, specifically the issue of hypoxia compromising cell viability engineered tissues. To overcome this hurdle, novel approach using microfluidic bioprinter is used to create two-layer structure resembling human ovary. incorporates liposomal oxygen-releasing system enhance viability. The technique enables simultaneous extrusion two distinct bioinks, namely, bioink A (comprising alginate 1% and 5 mg/mL PEGylated fibrinogen 20:1 molar ratio) B (containing 0.5%). In addition, catalase hydrogen peroxide (H
Language: Английский
Citations
2
Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 122992 - 122992
Published: Aug. 16, 2024
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 35(1)
Published: Nov. 30, 2024
Abstract Hybrid nanocomposite hydrogels consist of the homogeneous incorporation nano‐objects in a hydrogel matrix. The latter, whether made natural or synthetic materials, possesses microporous, soft structure that makes it an ideal host for variety polymer and lipid‐based as well metal‐ silica‐based ones. By carefully choosing composition proportions different constituents, hybrid can display wide array properties, from simple enhancement mechanical characteristics to specific bioactivity. This review aims provide overview state art highlighting key aspects make them promising choice biomedical applications. Strategies preparation are discussed by covering selection individual components. will also explore physico‐chemical rheological characterization these which is essential understanding their function, ultimately satisfying specifications intended use. Successful examples applications be presented, main challenges met discussed, with aim stimulating research community exploit full potential materials.
Language: Английский
Citations
1
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114338 - 114338
Published: Oct. 24, 2024
Language: Английский
Citations
0