National Science Review,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 12, 2024
ABSTRACT
Immunotherapy,
a
monumental
advancement
in
antitumor
therapy,
still
yields
limited
clinical
benefits
owing
to
its
unguaranteed
efficacy
and
safety.
Therapeutic
systems
derived
from
cellular,
bacterial
viral
sources
possess
inherent
properties
that
are
conducive
immunotherapy.
However,
crude
biomimetic
have
restricted
functionality
may
produce
undesired
toxicity.
With
advances
biotechnology,
various
toolkits
available
add
or
subtract
certain
of
living
organisms
create
flexible
therapeutic
platforms.
This
review
elaborates
on
the
creation
bioengineered
systems,
via
gene
editing,
synthetic
biology
surface
engineering,
enhance
The
modifying
strategies
discussed,
including
equipment
for
navigation
recognition
improve
precision,
introduction
controllable
components
control
duration
intensity
treatment,
addition
immunomodulatory
amplify
immune
activation,
removal
toxicity
factors
ensure
biosafety.
Finally,
we
summarize
advantages
immunotherapeutic
possible
directions
their
translation.
Biomacromolecules,
Journal Year:
2023,
Volume and Issue:
25(1), P. 222 - 237
Published: Dec. 22, 2023
Phenylboronic
acid
(PBA)
has
been
highly
acknowledged
as
a
significant
cancer
recognition
moiety
in
sialic
acid-overexpressing
cells.
In
this
investigation,
lipid-mediated
biomaterial
integrated
PBA
molecules
onto
the
surface
of
natural
killer
(NK)
cells
to
make
receptor-mediated
immune
cell
therapeutic
module.
Therefore,
1,2-distearoyl-sn-glycero-3-phosphorylethanolamine
(DSPE)
lipid-conjugated
di–PEG–PBA
(DSPEPEG-di(PEG–PBA)
was
synthesized.
The
DSPEPEG-di(PEG–PBA)
exhibited
high
affinity
for
(SA),
confirmed
by
fluorescence
spectroscopy
at
pH
6.5
and
7.4.
successfully
anchored
NK
surfaces
(PBA-NK),
maintains
intrinsic
properties
such
viability,
ligand
availability
(FasL
&
TRAIL),
cytokine
secretion
response
LPS.
anticancer
efficacy
PBA-NK
evaluated
against
2D
(MDA-MB-231,
HepG2,
HCT-116)
3D
tumor
spheroids
MDA-MB-231
greatly
enhanced
effects
SA-overexpressing
Thus,
represent
new
strategy
immunotherapy.
Tissue Engineering Part B Reviews,
Journal Year:
2023,
Volume and Issue:
30(3), P. 327 - 339
Published: Oct. 13, 2023
Ischemic
vascular
diseases
remain
leading
causes
of
disability
and
death.
Although
various
clinical
therapies
have
been
tried,
reperfusion
injury
is
a
major
issue,
occurring
when
blood
recirculates
at
the
damaged
lesion.
As
an
alternative
approach,
cell-based
therapy
has
emerged.
Mesenchymal
stem
cells
(MSCs)
are
attractive
cellular
candidates
due
to
their
therapeutic
capacities,
including
differentiation,
safety,
angiogenesis,
tissue
repair.
However,
low
levels
receptors/ligands
limit
targeted
migration
cells.
Thus,
it
important
improve
homing
efficacy
transplanted
MSCs
toward
endothelium.
Among
MSC
modulations,
ex
vivo
cell
surface
engineering
could
effectively
augment
efficiency
by
decorating
surfaces
with
receptors/ligands,
thereby
facilitating
intercellular
interactions
Especially,
exogenous
decoration
peptides
onto
provide
appropriate
functional
signaling
moieties
achieve
sufficient
homing.
Based
on
protein-like
functionalities,
high
modularity
in
molecular
design,
specific
affinities
multivalency
target
receptors,
be
representative
surface-presentable
moieties.
Moreover,
feature
mild
synthetic
process,
enabling
precise
control
amino
acid
composition
sequence.
Such
achieved
primarily
hydrophobic
bilayer
peptide-conjugated
anchor
modules
covalent
conjugation
between
available
compartments
membranes.
To
this
end,
review
provides
overview
currently
peptide-mediated,
strategies
for
enhancing
endothelial
Stem
techniques
using
peptide-based
bioconjugates
potential
revolutionize
current
disease
treatments
while
addressing
technical
limitations.
(IVDs)
global
health
issues.
show
promise
treatment,
ability
limitation
that
restricts
effectiveness.
address
drawback,
modification
can
enhance
migration,
homing,
restoration.
This
focuses
developed,
treating
IVDs.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(27), P. 18046 - 18057
Published: June 27, 2024
Tumor
metastasis
remains
a
major
challenge
in
cancer
management.
Among
various
treatment
strategies,
immune
cell-based
therapy
holds
great
potential
for
inhibiting
metastasis.
However,
its
wide
application
is
restricted
by
complex
preparations,
as
well
inadequate
homing
and
controllability.
Herein,
we
present
groundbreaking
approach
bioorthogonally
manipulating
tumor-NK
(natural
killer)
cell
assembly
to
inhibit
tumor
Multiple
dibenzocyclootyne
(DBCO)
groups
decorated
long
single-stranded
DNA
were
tail-modified
on
core–shell
upconversion
nanoparticles
(CSUCNPs)
condensed
photosensitive
chemical
linker
(PC-Linker)
shield
most
of
the
DBCO
groups.
On
one
hand,
light-triggered
scaffolds
formed
cross-linked
network
click
chemistry,
effectively
impeding
migration.
other
efficient
cellular
facilitated
effective
communication
between
cells
NK-92
cells,
leading
enhanced
response
against
tumors
further
suppression
These
features
make
our
strategy
highly
applicable
range
metastatic
cancers.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(46), P. 12087 - 12102
Published: Jan. 1, 2024
Although
natural
killer
(NK)
cell-based
adoptive
cell
transfer
(ACT)
has
shown
promise
in
cancer
immunotherapy,
its
efficacy
against
solid
tumors
is
limited
the
immunosuppressive
tumor
microenvironment
(TME).
Combinatorial
therapies
involving
chemotherapeutic
drugs
such
as
gemcitabine
(Gem)
and
NK
cells
have
been
developed
to
modulate
TME;
however,
their
clinical
application
constrained
by
low
drug
delivery
efficiency
significant
off-target
toxicity.
In
this
study,
we
membrane-immobilized
Gem
conjugates
(
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1556 - 1556
Published: Jan. 26, 2024
Current
cytokine-based
natural
killer
(NK)
cell
priming
techniques
have
exhibited
limitations
such
as
the
deactivation
of
biological
signaling
molecules
and
subsequent
insufficient
maturation
population
during
mass
cultivation
processes.
In
this
study,
we
developed
an
amphiphilic
trigonal
1,2-distearoyl-sn-glycero-3-phosphorylethanolamine
(DSPE)
lipid-polyethylene
glycol
(PEG)
material
to
assemble
NK
clusters
via
multiple
hydrophobic
lipid
insertions
into
cellular
membranes.
Our
conjugate-mediated
ex
vivo
sufficiently
augmented
structural
modulation
clusters,
facilitated
diffusional
signal
exchanges,
finally
activated
with
clusters.
Without
any
inhibition
in
exchanges
intrinsic
proliferative
efficacy
cells,
effectively
prime
produced
increased
interferon-gamma,
especially
early
culture
periods.
conclusion,
present
study
demonstrates
that
our
novel
conjugates
could
serve
a
promising
alternative
for
future
production.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(11), P. 4162 - 4186
Published: Nov. 1, 2024
A
living
cell
is
an
intricate
machine
that
creates
subregions
to
operate
functions
effectively.
Subcellular
dysfunction
has
been
identified
as
a
potential
druggable
target
for
successful
drug
design
and
therapy.
The
treatments
based
on
intracellular
polymerization,
self-assembly,
or
transformation
offer
various
advantages,
including
enhanced
blood
circulation
of
monomers,
long-term
delivery
pharmacokinetics,
low
resistance,
the
ability
deep
tissues
organelles.
In
this
review,
we
discuss
latest
developments
synthesis
applied
precisely
control
cellular
functions.
First,
applications
endogenous
exogenous
stimuli-triggered
dynamic
morphology
biomolecules
at
subcellular
level.
Second,
highlight
benefits
these
strategies
in
cancer
diagnosis
treatment
modulating
states
metabolism
systems.
Finally,
conclude
recent
progress
field,
future
perspectives,
analyze
challenges
functional
reactions
regulation,
find
opportunities.
National Science Review,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 12, 2024
ABSTRACT
Immunotherapy,
a
monumental
advancement
in
antitumor
therapy,
still
yields
limited
clinical
benefits
owing
to
its
unguaranteed
efficacy
and
safety.
Therapeutic
systems
derived
from
cellular,
bacterial
viral
sources
possess
inherent
properties
that
are
conducive
immunotherapy.
However,
crude
biomimetic
have
restricted
functionality
may
produce
undesired
toxicity.
With
advances
biotechnology,
various
toolkits
available
add
or
subtract
certain
of
living
organisms
create
flexible
therapeutic
platforms.
This
review
elaborates
on
the
creation
bioengineered
systems,
via
gene
editing,
synthetic
biology
surface
engineering,
enhance
The
modifying
strategies
discussed,
including
equipment
for
navigation
recognition
improve
precision,
introduction
controllable
components
control
duration
intensity
treatment,
addition
immunomodulatory
amplify
immune
activation,
removal
toxicity
factors
ensure
biosafety.
Finally,
we
summarize
advantages
immunotherapeutic
possible
directions
their
translation.
