Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 319 - 330
Published: Nov. 23, 2024
Language: Английский
Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Two-dimensional rare earth-containing nanomaterials are promising candidates in biomedical applications such as drug delivery, bio-imaging, antibacterial and cancer treatment due to their unique structure versatile energy levels.
Language: Английский
Citations
2
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become critical strategy for treatment. PANoptosis, newly discovered form of regulated death, integrates key molecular components pyroptosis, apoptosis, and necroptosis, activating these three pathways simultaneously achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits growth resistance activates strong anti‐tumor immune response, making tumor‐specific induction potential therapeutic strategy. Currently, treatment research related is focused mainly on the development small molecules cytokines. However, approaches still face limitations terms metabolic stability tumor specificity. The unique physicochemical properties biological activities nanomaterials hold promise optimizing strategies. This review summarizes concept mechanisms highlights latest applications nanoagents PANoptosis‐based anti‐cancer therapy, discusses challenges future directions clinical translation. It hoped that this will inspire further exploration treatments, providing new perspectives researchers field.
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become critical strategy for treatment. PANoptosis, newly discovered form of regulated death, integrates key molecular components pyroptosis, apoptosis, and necroptosis, activating these three pathways simultaneously achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits growth resistance activates strong anti‐tumor immune response, making tumor‐specific induction potential therapeutic strategy. Currently, treatment research related is focused mainly on the development small molecules cytokines. However, approaches still face limitations terms metabolic stability tumor specificity. The unique physicochemical properties biological activities nanomaterials hold promise optimizing strategies. This review summarizes concept mechanisms highlights latest applications nanoagents PANoptosis‐based anti‐cancer therapy, discusses challenges future directions clinical translation. It hoped that this will inspire further exploration treatments, providing new perspectives researchers field.
Language: Английский
Citations
1
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 045035 - 045035
Published: June 10, 2024
Chemotherapeutic agents hold significant clinical potential in combating tumors. However, delivering these drugs to the tumor site for controlled release remains a crucial challenge. In this study, we synthesize and construct glutathione (GSH) acid dual-responsive bismuth-based nano-delivery platform (BOD), aiming sonodynamic enhancement of docetaxel (DTX)-mediated therapy. The bismuth nanomaterial can generate multiple reactive oxygen species under ultrasound stimulation. Furthermore, loading DTX form BOD effectively reduces toxicity bloodstream, ensuring its cytotoxic effect is predominantly exerted at site. be well released high expression GSH acidic microenvironment. Meanwhile, also promote DTX. Results from both
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 319 - 330
Published: Nov. 23, 2024
Language: Английский
Citations
0