Targeting Hydrogel for Intelligent Recognition and Spatiotemporal Control in Cell‐Based Therapeutics

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 14, 2024

Abstract Smart drug platforms based on spatiotemporally controlled release and integration of tumor imaging are expected to overcome the inefficiency uncertainty traditional theranostic modes. In this study, a composite consisting thermosensitive hydrogel (polyvinyl alcohol‐carboxylic acid (PCF)) multifunctional nanoparticle (Fe 3 O 4 @Au/Mn(Zn)‐4‐carboxyphenyl porphyrin/polydopamine (FAM x P)) is developed combine immunogenic cell death (ICD)/immune checkpoint blockade (ICB) therapy under guidance magnetic resonance (MRI) fluorescence (FI). It can not only further recognize target cells through folate receptor cells, but also produce thermal dissolution after exposure near‐infrared light slowly FAM P in situ, thereby prolonging treatment time avoiding recurrence. As entered it released pH‐dependent manner. Chemodynamic, photothermal photodynamic cause significant ICD cancer cells. ICB thus be enhanced by injecting anti‐programmed ligand 1, improving effectiveness treatment. The PCF‐FAM may represent an updated design approach with simple compositions for cooperative MRI/FI‐guided targeted therapeutic pathways tumors.

Language: Английский

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Applied research and recent advances in the development of flexible sensing hydrogels from cellulose: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136100 - 136100

Published: Oct. 24, 2024

Language: Английский

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Advances in photo-responsive hydrogel integrated with biomedical materials for antitumor applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 220, P. 113431 - 113431

Published: Sept. 3, 2024

Language: Английский

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Adhesive conductive wood-based hydrogel with high tensile strength as a flexible sensor

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 122954 - 122954

Published: Nov. 14, 2024

Language: Английский

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A Shikonin-Iron-Tragacanth gum nanocomplex for synergistic treatment of bladder cancer

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159202 - 159202

Published: Jan. 5, 2025

Language: Английский

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Transdermal Delivery of Resveratrol by a Nanomicelle-Loaded Enzyme-Triggered Hydrogel for Diabetic Wound Healing

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

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Cellulose-based hydrogels in cancer diagnostic and therapy

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 307 - 325

Published: Jan. 1, 2025

Language: Английский

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Tailoring of a specific pH-induced self-enhanced photothermal cellulose hydrogel for antibiotic-resistant bacteria-infected wound treatment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 513, P. 163025 - 163025

Published: April 23, 2025

Language: Английский

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Injectable natural hydrogel with spatiotemporal self-strengthening, antibacterial and anti-inflammatory properties for treating diabetic wound

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154802 - 154802

Published: Aug. 13, 2024

Language: Английский

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One-step construction of silver nanoparticles immersed hydrogels by triple-helix β-glucans and the application in infectious wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137146 - 137146

Published: Oct. 1, 2024

Language: Английский

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