Preparation and Characterization of Agnws Conductive Hydrogel with High Mechanical Performance, High Electrical Conductivity, and Biocompatibility DOI

Fengxv Wang,

Shui Guan,

Chuzhou Wen

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

One‐Step Formed Janus Hydrogel with Time‐Space Regulating Properties for Suture‐Free and High‐Quality Tendon Healing DOI Creative Commons

Chenguang Ouyang,

Tian Tu, Haojie Yu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Janus hydrogels have promising applications in tendon healing and anti-peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, unstable adhesion interfaces severely limited application suture-free high-quality healing. In this work, by controlling the interfacial distribution of free -COOH groups cationic-π structures on both sides hydrogels, a series PZBA-EGCG-ALC with varying degrees asymmetric properties are successfully prepared using simple efficient one-step synthesis method. The tensile strength elongation at break hydrogel as high 0.51 ± 0.04 MPa 922.89 28.59%. addition, can achieve difference (nearly 20-fold) while maintaining strong bottom (up to 524.8 33.1 J m-2). spatial dimension, its excellent compliance one-sided behavior provide effective support physical barriers for injured Achilles tendons. More importantly, also minimize early inflammation generation time dimension via ROS-responsive PZBA-EGCG prodrug macromolecules. This study provided more convenient strategy constructing promote

Language: Английский

Citations

3
Harnessing bi-layered supramolecular Janus tissue-adhesive/anti-adhesive fibrous hydrogel for efficient hemostasis, wound healing, and suppressing postoperative tissue adhesion DOI
Shah Mehmood, Hewan Dawit, Zahid Hussain

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153095 - 153095

Published: June 13, 2024

Language: Английский

Citations

9
Double‐Dynamic‐Bond Cross‐Linked Hydrogel Adhesive with Cohesion‐Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing DOI Open Access
Ming Yan, Shiyu Hu,

H TAN

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing repair. However, the negative correlation between mechanical strength poses a challenge their practical application. Herein, bio‐inspired cohesive enhancement strategy is developed to prepare adhesive simultaneously enhanced adhesion. double cross‐linked network achieved through cooperation polyacrylic acid grafted N‐hydroxy succinimide crosslinked by tannic cohesion‐enhanced ion crosslinking of sodium alginate Ca 2+ . Such unique structure endows resultant excellent strength. capable various organs in vitro, exhibits satisfactory on‐demand removability, antibacterial, antioxidant properties. As proof concept, not only effectively halts non‐compressible hemorrhages beating heart femoral artery models rats, but also accelerates healing infected wound inhibiting bacteria reducing inflammation. Overall, this advanced promising as an emergency rescue that enables robust closure, timely controlling bleeding, promoting damaged healing.

Language: Английский

Citations

1
Electrostatically Enhanced Biomimetic Asymmetric Hydrogel with a Dung Beetle-Inspired Pattern for Internal Trauma Sealing DOI
Lei Liang, Haitao Zhang, Yue Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Herein, a biologically asymmetric adhesion-patterned hydrogel induced by the dung beetle surface was proposed for internal trauma sealing. The electrostatic interaction-enhanced dual networks endowed patch with superior mechanical performance, thus achieving favorable sealing ability. Poly(acrylic acid) (pAA), chitooligosaccharide (COS), and gelatin were used as composition of our system. Concurrently, bionic raised structure enabled significant adhesion drop effect. waviness function, fitted to curved bumps, showed design direction patterned which indicative subsequent research. Also, microparticle deposition method could exert synergistic effect surface, together contributed asymmetry adhesive patch. Following simulation experiments such in vitro bursting tests, we conducted rat gastric model validate application potential this had an excellent effect, antiadhesive properties, operability expected have promising prospect, providing strategy vivo trauma-sealing biomaterials.

Language: Английский

Citations

0
Applications of Hydrogels in Emergency Therapy DOI Creative Commons
Mariana Chelu, Mónica Popa,

José María Calderón Moreno

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 234 - 234

Published: March 23, 2025

Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.

Language: Английский

Citations

0
Nanofibrous membrane/self-healing hydrogel double-layer nanocomposite dressings based on oxidized dextran and carboxymethyl chitosan loading ZIF-nanozyme for enhanced bacterial-infected diabetic wound healing DOI
Hongyuan Fang,

Weizhong Yuan

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 313, P. 144292 - 144292

Published: May 16, 2025

Language: Английский

Citations

0
Novel asymmetrical double-layer structural adhesive hydrogels with synergetic neuroprotection and angiogenesis effect for diabetic wound healing DOI

Zhihong Su,

Wanjun Zhang, Zhiqing Mo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159081 - 159081

Published: Dec. 1, 2024

Language: Английский

Citations

2
Biomimetic poly(thioctic acid)-based bioadhesive hydrogels for wet adhesion, expeditious hemostasis and enhanced wound healing DOI
Chen Wang,

Fangzheng Yu,

Yuan Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137108 - 137108

Published: Oct. 1, 2024

Language: Английский

Citations

1
Preparation and Characterization of Agnws Conductive Hydrogel with High Mechanical Performance, High Electrical Conductivity, and Biocompatibility DOI

Fengxv Wang,

Shui Guan,

Chuzhou Wen

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0