Chemical Proteomics Reveals That Camptothecin Weakens Insect Immunity against Bacteria by Suppressing Antimicrobial Peptide Expression DOI
Huan Liu, Yi Ding,

Dongdong Huang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Plant natural products are crucial in defending against herbivorous insects and widely used pest control, yet their mechanisms remain complex insufficiently studied. This study employed a reverse strategy to investigate the mechanism of camptothecin (CPT), botanical pesticide. By using CPT-based chemical probe coupled with proteomic analysis, immune-related proteins, including those involved prophenoloxidase (PPO) activation antimicrobial peptide (AMP) synthesis, were identified Asian corn borer, Ostrinia furnacalis. The findings demonstrated that CPT weakens insect immunity, primarily by inhibiting AMP synthesis rather than affecting PPO activation. Specifically, downregulated expression genes IMD pathway encoding AMPs (attacin gloverin). Additionally, CPT-fed exhibited reduced antibacterial activity. research uncovers novel as an immunosuppressant, offering new insights may enhance application control.

Language: Английский

Macromolecules-based encapsulation of pesticides with carriers: A promising approach for safe and effective delivery DOI
Roohallah Saberi Riseh,

Masoumeh Vatankhah,

Mohadeseh Hassanisaadi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132079 - 132079

Published: May 3, 2024

Language: Английский

Citations

9
Cellulase-responsive hydroxypropyl cellulose-anchored hollow mesoporous silica carriers for pesticide delivery DOI
Ziwei Wu, Yiyang Chen, Xue Gong

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134612 - 134612

Published: Aug. 8, 2024

Language: Английский

Citations

4
Two Birds with One Stone: Eco‐Friendly Nano‐Formulation Endows a Commercial Fungicide with Excellent Insecticidal Activity DOI Open Access

Dongdong Huang,

Huitang Qi,

Huan Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract The development of multi‐action pesticides presents significant advantages, including cost‐effectiveness, reduced application frequency, enhanced resistance management, and minimized environmental impact. Despite its efficacy in targeting chitin synthase both fungi insects, the insecticidal performance polyoxin B remains limited. To overcome this limitation, a novel nano‐formulation, B@ZTS is developed, utilizing agricultural byproducts, tea saponin, zein. This formulation features small particle size, high leaf deposition efficiency, excellent dispersion properties. Leveraging disulfide bond system, designed to respond intracellular reducing environment, enabling controlled release B. Remarkably, nano‐formulation facilitates penetration physiological barriers, achieving equivalent fungicidal at only one‐fifth dosage. work highlights potential eco‐friendly, cost‐effective, multifunctional nano‐pesticides, providing compelling solution for sustainable practices demonstrating broad applicability integrated pest disease management.

Language: Английский

Citations

0
Zein and resveratrol Schiff base nanocomplexes: An efficient delivery system to enhance the antibacterial efficacy of berberine DOI
Peng Ju,

Leliang Zhou,

Jixiang Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141496 - 141496

Published: Feb. 26, 2025

Language: Английский

Citations

0
Multiresponsive Zein Nanospheres for Avermectin B2 Delivery: Enhancing Root-Knot Nematode Control and Safety to Nontarget Organisms DOI
Xiquan Ding, Qian Du, Fei Gao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Root-knot nematodes are globally prevalent plant-parasitic pests, distinguished by their widespread distribution, extensive host range, and challenging control measures. Avermectin B2, one of the few effective nematicides available, faces limitations in efficacy poses environmental concerns due to its eco-unfriendly composition poor utilization traditional emulsifiable concentrate (EC) formulations. In this study, we developed core-shell structured Ave B2-BS@Zein@SC nanospheres, incorporating zein as carrier, sodium caseinate stabilizer, butyl stearate temperature "switch". These nanospheres demonstrated multiresponsive characteristics temperature, pH, enzymatic conditions, facilitating rapid pesticide release under elevated temperatures, mildly acidic or alkaline presence protease. controlled-release properties effectively responded both factors during nematode outbreaks intestinal conditions nematodes, enhancing targeting efficiency. The engineered improved mobility stability avermectin B2 soil, enabling more comprehensive across broader deeper soil layers. Additionally, penetration capability into plant roots eliminated that had already invaded root system, thereby strengthening crop protection. Crucially, enhanced safety for nontarget organisms. This environmentally conscious, nanodelivery system presents a promising strategy sustainable subterranean pest management.

Language: Английский

Citations

0
Tea tree oil Pickering emulsions stabilized by sodium lignosulfonate-zein covalent conjugate for fungicide delivery and enhanced control efficacy against peanut sclerotium blight DOI
Jihao Zuo,

Yitong Lin,

Jiayuan Tian

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162876 - 162876

Published: April 1, 2025

Language: Английский

Citations

0
Influence of Nanopesticide Surface Chemistry on Adsorption to Plant Cuticle and Wax Layer: The Role of Zeta Potential and Wetting DOI
Yashwanth Arcot, Minchen Mu,

Monica Iepure

et al.

Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: unknown, P. 105190 - 105190

Published: Sept. 1, 2024

Language: Английский

Citations

0
pH/Enzyme-responsive nanocarrier pesticide delivery system: Realizing targeted release in pest gut for enhanced Apis cerana safety DOI

Pengrui Du,

Xuehua Shao, Hao Wu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158419 - 158419

Published: Dec. 8, 2024

Language: Английский

Citations

0
Bioavailability and Environmental Safety of Nanoinsecticides DOI

R. Anbalagan,

Jayalakshmi Krishnan, Swathy Kannan

et al.

Nanotechnology in the life sciences, Journal Year: 2024, Volume and Issue: unknown, P. 147 - 165

Published: Jan. 1, 2024

Language: Английский

Citations

0
Chemical Proteomics Reveals That Camptothecin Weakens Insect Immunity against Bacteria by Suppressing Antimicrobial Peptide Expression DOI
Huan Liu, Yi Ding,

Dongdong Huang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Plant natural products are crucial in defending against herbivorous insects and widely used pest control, yet their mechanisms remain complex insufficiently studied. This study employed a reverse strategy to investigate the mechanism of camptothecin (CPT), botanical pesticide. By using CPT-based chemical probe coupled with proteomic analysis, immune-related proteins, including those involved prophenoloxidase (PPO) activation antimicrobial peptide (AMP) synthesis, were identified Asian corn borer, Ostrinia furnacalis. The findings demonstrated that CPT weakens insect immunity, primarily by inhibiting AMP synthesis rather than affecting PPO activation. Specifically, downregulated expression genes IMD pathway encoding AMPs (attacin gloverin). Additionally, CPT-fed exhibited reduced antibacterial activity. research uncovers novel as an immunosuppressant, offering new insights may enhance application control.

Language: Английский

Citations

0