Engineering the novel azobenzene‐based molecular photoswitches for suppressing bacterial infection through dynamic regulation of biofilm formation DOI

Taihong Zhang,

Yi‐Ke Yang,

Yu‐Mei Feng

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract BACKGROUND Bacterial biofilm is a strong fortress for bacteria to resist harsh external environments, which can enhance their tolerance and exacerbate the drug/pesticide resistance risk. Currently, photopharmacology provides an advanced approach via precise spatiotemporal control regulating biological activities by light‐controlling molecular configurations, thereby having enormous potential in development of drug/pesticides. RESULTS To further expand application discovering new antibiofilm agents, we prepared series light‐controlled azo‐active molecules explored photo isomerization, fatigue resistance, anti‐biofilm performance. Furthermore, mechanisms inhibiting formation were systematically investigated. Overall, designed azo‐derivative A11 featured excellent anti‐ Xoo activity with half‐maximal effective concentration (EC 50 ) value 5.45 μg mL −1 , EC could be elevated 2.19 after ultraviolet irradiation (converted as cis ‐configuration). The photo‐switching behavior showed that had outstanding anti‐fatigue properties. An in‐depth analysis action mechanism effectively inhibit expression relevant virulence factors. This performance dynamically regulated loading private light‐switch property. CONCLUSION In this work, azo provide model resisting bacterial infection dynamic regulation formation. © 2024 Society Chemical Industry.

Language: Английский

Engineering the novel azobenzene‐based molecular photoswitches for suppressing bacterial infection through dynamic regulation of biofilm formation DOI

Taihong Zhang,

Yi‐Ke Yang,

Yu‐Mei Feng

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract BACKGROUND Bacterial biofilm is a strong fortress for bacteria to resist harsh external environments, which can enhance their tolerance and exacerbate the drug/pesticide resistance risk. Currently, photopharmacology provides an advanced approach via precise spatiotemporal control regulating biological activities by light‐controlling molecular configurations, thereby having enormous potential in development of drug/pesticides. RESULTS To further expand application discovering new antibiofilm agents, we prepared series light‐controlled azo‐active molecules explored photo isomerization, fatigue resistance, anti‐biofilm performance. Furthermore, mechanisms inhibiting formation were systematically investigated. Overall, designed azo‐derivative A11 featured excellent anti‐ Xoo activity with half‐maximal effective concentration (EC 50 ) value 5.45 μg mL −1 , EC could be elevated 2.19 after ultraviolet irradiation (converted as cis ‐configuration). The photo‐switching behavior showed that had outstanding anti‐fatigue properties. An in‐depth analysis action mechanism effectively inhibit expression relevant virulence factors. This performance dynamically regulated loading private light‐switch property. CONCLUSION In this work, azo provide model resisting bacterial infection dynamic regulation formation. © 2024 Society Chemical Industry.

Language: Английский

Citations

6