Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101346 - 101346
Published: Nov. 16, 2024
Language: Английский
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125508 - 125508
Published: March 1, 2025
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 407 - 407
Published: March 28, 2025
Impeded by the limited light penetration of photodynamic therapy (PDT) to tissues and hypoxic environment solid tumors, clinical therapeutic efficacy application are below expectations. In this study, a glutathione (GSH)-responsive nano-photosensitizer, based on chlorquinaldol (CQD)-loaded iron-containing nanorod composed meso-tetra (4-carboxyphenyl) porphyrin (TCPP), was prepared serve as laser-ignited ferroptosis sensitizer improve tumoricidal effect PDT. tumor microenvironment (TME) with elevated GSH levels, cargos ferrous ions released accompanied degradation nano-photosensitizer exhaustion. This not only increases liable iron pool (LIP) accumulation but also decreases peroxidase 4 (GPX4) activity Simultaneously, exhaustion disrupts intracellular redox homeostasis, heightening NIR irradiation-triggered photosensitive oxidative stress. Moreover, CQD elevates level reactive oxygen species (ROS), enabling nanorods gain an radical generation ability enhancing efficacy. Strikingly, exacerbates downregulation GPX4 expression promote lipid peroxides. Therefore, we herald new paradigm for synergistically potentiating PDT “all-in-one” through multi-pronged upregulation sensitivity.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137893 - 137893
Published: Nov. 1, 2024
Language: Английский
Citations
3
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 123136 - 123136
Published: Dec. 11, 2024
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
The therapeutic effectiveness of photothermal therapy (PTT) is limited by heat tolerance and PTT-induced inflammation, which increases the risk tumor metastasis recurrence. Ferroptosis combined with PTT can achieve significant effects. In this work, we designed self-healing nanotherapeutics to effective triple-amplified ferroptosis cascade inflammation inhibition after treatment. After ferroptosis-inducing ability mangiferin (MF) was first elucidated, nanocomplex PFeM, coordinated Fe
Language: Английский
Citations
1
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 26276 - 26286
Published: Nov. 5, 2024
Photodynamic therapy (PDT) has emerged as a promising noninvasive modality for cancer treatment. However, its therapeutic efficacy is often compromised by the inadequate oxygen supply and overexpressed glutathione (GSH) in tumor microenvironment (TME). Herein, multifunctional core–shell nanocomposite CaLI@Z-FA was constructed targeted enhanced photodynamic/photothermal synergistic against hypoxic tumors. The integration of l-Arg addresses limitation reactive species (ROS) singularity traditional PDT generating nitric oxide (NO), which synergistically enhances efficacy. Folic acid (FA) modification on surface significantly improves targeting, enhancing accumulation nanoparticles at site. Upon reaching acidic TME, ZIF-8 shell decomposed to release CaO2, generated O2 situ relieve hypoxia enhance ICG under near-infrared irradiation. Meanwhile, PDT-induced singlet (1O2) catalyzed l-Arginine oxide, sensitized depleting intracellular GSH reacted with 1O2 generate highly antitumor nitrogen species. Moreover, photothermal effect calcium overload-mediated cell death further potentiated Both vitro vivo studies demonstrated tumor-targeting property, oxidative damage, outstanding outcomes CaLl@Z-FA negligible systemic toxicity. This O2-generating GSH-depleted nanoplatform provides an effective paradigm phototherapy.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101346 - 101346
Published: Nov. 16, 2024
Language: Английский
Citations
0