Engineered hydrogel microspheres for spheroids and organoids construction

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155131 - 155131

Published: Aug. 24, 2024

Language: Английский

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Glucose-triggered NIR-responsive photothermal antibacterial gelatin/dextran hydrogel simultaneously targeting the high glucose and infection microenvironment in diabetic wound

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140325 - 140325

Published: Jan. 1, 2025

Language: Английский

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Comprehensive Review of Hydrogel Synthesis, Characterization, and Emerging Applications

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(11), P. 457 - 457

Published: Nov. 4, 2024

Hydrogels play a crucial role due to their high-water content and 3D structure, which make them ideal for various applications in biomedicine, sensing, beyond. They can be prepared from variety of biomaterials, polymers, combinations, allowing versatility properties applications. include natural types derived collagen, gelatin, alginate, hyaluronic acid, as well synthetic based on polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide (PAAm). Each type possesses distinct properties, such mechanical strength, biodegradability, biocompatibility, tailored wound healing, contact lenses, bioprinting, tissue engineering. The hydrogels mimics environments, promoting cell growth nutrient waste exchange, supports the development functional tissues. serve scaffolds engineering applications, including cartilage bone regeneration, vascular engineering, organ-on-a-chip systems. Additionally, encapsulate deliver therapeutic agents, factors or drugs, specific target sites body. through three primary methods: physical crosslinking, relies non-covalent interactions entanglements hydrogen bonding; chemical forms covalent bonds between polymer chains create stable structure; irradiation-based where UV irradiation induces rapid hydrogel formation. choice crosslinking method depends desired hydrogel. By providing biomimetic environment, facilitate differentiation, support formation, aid regeneration damaged diseased tissues while delivering agents. This review focuses critical advancements processing routes development, summarizing characterization application hydrogels. It also details key healing challenges future perspectives field.

Language: Английский

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Polyphenol-enhanced wet adhesive hydrogel with synergistic mechanical activation and ROS scavenging for accelerating diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157103 - 157103

Published: Oct. 1, 2024

Language: Английский

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Pluripotent polysaccharide coordinated hydrogels remodel inflammation, neovascularization and reepithelization for efficient diabetic wound prohealing

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 37 - 53

Published: Nov. 17, 2024

Language: Английский

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Rapid Fluid-Induced-Expanding Chitosan-Derived Hemostatic Sponges with Excellent Antimicrobial and Antioxidant Properties for Incompressible Hemorrhage and Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: 26(1), P. 689 - 704

Published: Jan. 1, 2025

Chitosan-based materials are known for their excellent biocompatibility and inherent hemostatic properties. However, efficiency is significantly affected by poor wettability mechanical strength. Herein, we developed a novel super elastic sponge from mussel-inspired chitosan modified with long alkyl catechol functional groups (HMCC) via simple freezing-drying procedure. The incorporation of decanal in the HMCC enhances its antimicrobial antioxidant properties facilitates multiple interactions blood cells, thus promoting enrichment rapid hemostasis. Moreover, sponges exhibit high compressibility fluid-induced size recovery capacity, enabling wound shape adaptation to ensure minimizing irritation. In vivo experiments revealed that possessed enhanced procoagulant, hemostasis abilities, favorable degradability could promote healing rat skin model. These results highlight potential as promising solution clinical management major bleeding.

Language: Английский

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Antioxidant effects of Gastrodia elata polysaccharide-based hydrogels loaded with puerarin/gelatin microspheres for D-galactose-induced aging-skin wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139809 - 139809

Published: Jan. 11, 2025

Language: Английский

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The preparation of methacrylated oxidized konjac glucomannan hydrogel system and its treatment for diabetic wounds

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140005 - 140005

Published: Jan. 1, 2025

Language: Английский

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The application of traditional Chinese medicine polysaccharides in wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140993 - 140993

Published: Feb. 12, 2025

Language: Английский

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Traditional Chinese Medicine-Loaded Hydrogels: An Emerging Strategy for the Treatment of Bone Infections

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 514 - 514

Published: April 14, 2025

Bone infection is a disease that seriously affects patients’ quality of life and physical health. Traditional treatment methods have many drawbacks. Hydrogels loaded with Chinese Medicine (TCM), as an emerging strategy, combine the advantages good biocompatibility hydrogels, adjustable drug release performance, multi-target synergistic TCM, showing great application potential. This article elaborates in detail on research progress hydrogels TCM for bone infections, including classification characteristics mechanism action preparation examples, advantages, challenges prospects faced. The aim to provide new ideas references clinical infections.

Language: Английский

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