An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. In vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role in vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine.

Language: Английский

Recent advances in tannic acid-based gels: Design, properties, and applications DOI
Zuwu Tang,

Ilnaz Fargul Chowdhury,

Jinbei Yang

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 339, P. 103425 - 103425

Published: Feb. 15, 2025

Language: Английский

Citations

2
An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine. Graphical

Language: Английский

Citations

1
Advancing Diabetic Wound Care: The Role of Copper-containing Hydrogels DOI Creative Commons

Mohammad Ebrahim Astaneh,

Narges Fereydouni

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38481 - e38481

Published: Sept. 26, 2024

Language: Английский

Citations

6
Multi-functional bioactive hydrogel based on CCM-Co-ZIF-8 nanoparticles for chronic wound healing: Synergistic antibacterial, antioxidant, and anti-inflammatory therapy DOI

Qi Tao,

Hang Yao,

Zehao Gu

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113824 - 113824

Published: Feb. 1, 2025

Language: Английский

Citations

0
Core‐Shell Structure‐Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing DOI Open Access

Shuangying Li,

Ren Li,

Xiuwen Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Herein, MIL‐88b‐NH 2 nanocage is designed with adenine inside the cage and tannins as gating outside cage. Based on this core‐shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously exogenously at different stages of wound healing. The engineered hydrogel have tunable adhesion intelligence. optimal PCMAT‐0.3 reduced pore size ≈13.5 µm under endogenous response conditions, antimicrobial performance reached more than 80% within 6 h. Tensile strength strain break by 8.47% 60.52% respectively exogenous conditions. Evaluation healing effect mouse back tissue shows that rate significantly better control group without incorporation day 14. It provides an idea for development smart dressing integrates multifunctionality.

Language: Английский

Citations

0
Self-healing hydrogel based on polyvinyl alcohol/dextran with hyperglycemia-triggered cascade enzyme catalytic activity promotes diabetic wound healing DOI
Dan Xia, Tingting Shi,

Wuxiu Cao

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137615 - 137615

Published: April 16, 2025

Language: Английский

Citations

0
Advances in Stimuli-Responsive Injectable Hydrogels for Biomedical Applications DOI
Xuebin Ma, Kanaparedu P. C. Sekhar, Peiyu Zhang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The development of new multi-responsive injectable hydrogels with cascades or even synergistic effects will be great significance in the field precision medicine.

Language: Английский

Citations

3
Construction of multifunctional hydrogel containing pH-responsive gold nanozyme for bacteria-infected wound healing DOI
Jinfeng Peng, Chang Liu, Meilan Mo

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137746 - 137746

Published: Nov. 1, 2024

Language: Английский

Citations

2
An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. In vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role in vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine.

Language: Английский

Citations

0