High‐Conductivity, Self‐Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human‐Machine Interactions Under Extreme Cold Conditions

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human‐machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, electrical conductivity. However, a major challenge remains in developing ICHs that simultaneously exhibit high ionic conductivity, self‐healing, strong adhesion, particularly under extreme low‐temperature conditions. In this study, novel ICH composed sulfobetaine methacrylate, methacrylic acid, TEMPO‐oxidized cellulose nanofibers, sodium alginate, lithium chloride is presented. The hydrogel designed with hydrogen‐bonded chemically crosslinked network, achieving excellent conductivity (0.49 ± 0.05 S m −1 ), adhesion (36.73 2.28 kPa), self‐healing capacity even at −80 °C. Furthermore, the maintain functionality over 45 days, showcasing outstanding anti‐freezing properties. This material demonstrates significant potential non‐invasive, continuous monitoring, adhering conformally skin without signal crosstalk, enabling real‐time, high‐fidelity transmission cryogenic These offer transformative next generation multimodal sensors, broadening application possibilities harsh environments, including weather outer space.

Language: Английский

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Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

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Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

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Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Recent advances in developing photonic technologies using various materials offer enhanced biosensing, therapeutic intervention, and non‐invasive imaging healthcare. Here, this article summarizes significant technological advancements materials, devices, bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, on‐skin health monitoring. The details of required necessary properties, device configurations are described next‐generation followed by an explanation the working principles light‐based therapeutics diagnostics. Next, paper shares recent examples integrated systems focusing on translation immediate clinical studies. In addition, limitations existing devices future directions smart discussed. Collectively, review focus trends new nanomaterials, light delivery methods, system designs, mechanical structures, material functionalization, to advance digital

Language: Английский

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Visual Performance and Satisfaction of Extended Depth of Focus Contact Lenses in Presbyopic Subjects

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 818 - 818

Published: Jan. 26, 2025

Background/Objectives: The objective was to assess visual performance and the overall satisfaction of extended-depth-of-focus (EDOF) contact lenses (CLs) in a presbyopic population. Methods: We prospectively investigated acuity at all distances (0.3, 0.4, 0.5, 0.7, 1, 5 m), higher-order aberrations (HOAs), contrast sensitivity function, score, before during EDOF CL wear 42 eyes 21 subjects (1 man 20 women). Results: Binocular 0.3, 2, 3, m when wearing CLs 0.01 ± 0.14, −0.08 0.02, 0.00, −0.07 respectively. found significant improvement near intermediate 0.5 but no change far (0.7, m) between wear. area under log function not significantly changed photopic nor mesopic conditions (p = 0.099, p 0.689). Ocular third-order aberrations, fourth-order or total HOAs for 4 mm pupil increased. score improved by CLs. Conclusions: distances, while maintaining vision, effect minimal, suggesting viability correction such candidates.

Language: Английский

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High-Accuracy Intermittent Strabismus Screening via Wearable Eye-Tracking and AI-Enhanced Ocular Feature Analysis

Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 110 - 110

Published: Feb. 14, 2025

An effective and highly accurate strabismus screening method is expected to identify potential patients provide timely treatment prevent further deterioration, such as amblyopia even permanent vision loss. To satisfy this need, work showcases a novel based on wearable eye-tracking device combined with an artificial intelligence (AI) algorithm. the minor occasional inconsistencies in during binocular coordination process, which are usually seen early-stage rarely recognized current studies, system captures temporally spatially continuous high-definition infrared images of eye wide-angle motion, inducing intermittent strabismus. Based collected motion information, 16 features oculomotor process strong physiological interpretations, help biomedical staff understand evaluate results generated later, calculated through introduction pupil-canthus vectors. These can be normalized, reflect individual differences. After these processed by random forest (RF) algorithm, experimentally yields 97.1% accuracy detection 70 people under diverse indoor testing conditions, validating high robustness method, implying that has support widespread screening.

Language: Английский

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The development history of flexible mechanical biosensors: Materials, technologies, and medical applications

Journal of Translational Critical Care Medicine, Journal Year: 2025, Volume and Issue: 7(2)

Published: April 2, 2025

The application of flexible mechanical biosensors in biological systems is revolutionizing health monitoring and medical practices, particularly the field critical care medicine. rapid development this enables real-time, efficient detection various signals within human body offers unique advantages, such as wearability, high sensitivity, multifunctionality. Flexible biosensors, including strain, pressure, bending, vibration, composite sensors, have extensive prospects applications, continuous blood pressure monitoring, motion tracking, posture analysis, heart sound physiological parameter detection. In settings, these sensors can significantly enhance patient treatment by enabling continuous, noninvasive vital signs other parameters, thereby leading to earlier complications, more accurate assessments conditions, timely interventions. Through a review existing literature, paper summarizes main trends, consensus, controversies, research gaps proposes future directions recommendations advance personalized smart care.

Language: Английский

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Advanced Sensory Hardware for Intelligent Eye‐Machine Interfacing: from Wearables to Bionics

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Eye‐machine interfacing (EMI) is playing a critical role in enabling effective and immersive human‐machine interaction (HMI), which of significance various fields related to the Internet Things (IoT), including VR/AR, autonomous driving, brain‐computer interface, robotics, biomedicine, etc. EMI realized by eye‐interfaced technologies, from wearable eye‐movement tracking theranostic smart contact lenses visual prosthetic implants bionic eyes, where progress being promoted rapid advancements corresponding sensory technologies toward vision reduced size, weight, power consumption (SWaP). Emerging functional materials, especially low‐dimensional nanomaterials, are key driving force flexible transparent design, multimodal intelligent sensing, up‐scaled, integrated processing advanced hardware. In recognition importance recent its this article provides review state‐of‐the‐art fundamentals, devices, highlighting nanomaterials‐based eye‐tracking, healthcare, prosthetics. Moreover, insights provided, form factors, in‐sensor computing architectures, biomimetic communicating methods envisioned, aiming at promoting elaborations on future applications optimized SWaP.

Language: Английский

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Design and In Vivo Evaluation of an Intraocular Electrode for Ciliary Muscle Biopotential Measurement in a Non-Human Primate Model of Human Accommodation

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 247 - 247

Published: April 13, 2025

The measurement of electrical potentials in the human body is becoming increasingly important healthcare as a valuable diagnostic parameter. In ophthalmology, while these signals are primarily used to assess retinal function, other applications, such recording accommodation-related biopotentials from ciliary muscle, remain poorly understood. Here, we present development and evaluation novel implantable ring electrode for muscle. Inspired by capsular tension rings, was fabricated using laser cutting, wiring, physical vapor deposition coating. constant impedance weight over simulated aging period 391 days, demonstrated electrode’s stability. vivo testing non-human primates further validated surgical handling long-term stability, with no delamination or tissue ingrowth after 100 days implantation. Recorded muscle (up 700 µV) exceeded amplitudes reported literature. While results promising, research needed investigate signal quality origin well correlation between activity. Ultimately, this will be an implanted device record control artificial lens designed restore accommodation individuals presbyopia.

Language: Английский

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Enhancing glaucoma care with smart contact lenses: An overview of recent developments

Biomedical Microdevices, Journal Year: 2025, Volume and Issue: 27(2)

Published: April 21, 2025

Abstract Glaucoma is a leading cause of irreversible blindness worldwide, affecting millions individuals due to its progressive damage the optic nerve, often caused by elevated intraocular pressure (IOP). Conventional methods IOP monitoring, such as tonometry, provide sporadic and inaccurate readings fluctuations throughout day, leaving significant gaps in diagnosis treatment. This review explores transformative potential smart contact lenses equipped with continuous monitoring therapeutic capabilities. These integrate advanced materials graphene, nanogels, magnetic oxide nanosheets alongside sophisticated biosensing wireless communication systems. By offering continuous, real-time data, these can detect subtle immediate feedback patients clinicians. Moreover, drug-eluting capabilities embedded present groundbreaking approach glaucoma therapy improving medication adherence providing controlled drug release directly eye. Beyond management, innovations also pave way for biochemical markers other ocular diseases. Challenges biocompatibility, long-term wearability, affordability remain, but integration cutting-edge technologies signifies paradigm shift care. developments hold immense promise advancing personalized medicine, patient outcomes, mitigating global burden blindness.

Language: Английский

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