Regulation of mTORC1 and its impact on gene expression at a glance DOI Open Access
Mathieu Laplante, David M. Sabatini

Journal of Cell Science, Journal Year: 2013, Volume and Issue: unknown

Published: Jan. 1, 2013

The mechanistic (or mammalian) target of rapamycin (mTOR) is a kinase that regulates key cellular functions linked to the promotion cell growth and metabolism. This kinase, which part two protein complexes termed mTOR complex 1 (mTORC1) 2 (mTORC2), has fundamental role in coordinating anabolic catabolic processes response factors nutrients. Of complexes, mTORC1 by far best characterized. When active, triggers proliferation promoting synthesis, lipid biogenesis, metabolism, reducing autophagy. fact deregulation associated with several human diseases, such as type diabetes, cancer, obesity neurodegeneration, highlights its importance maintenance homeostasis. Over last years, groups observed inhibition, addition deeply affects gene transcription. Here, we review connections between transcription focusing on impact regulating activation specific including STAT3, SREBPs, PPARγ, PPARα, HIF1α, YY1–PGC1α TFEB. We also discuss these mediating effects various physiological pathological contexts.

Language: Английский

mTOR Signaling in Growth Control and Disease DOI Creative Commons
Mathieu Laplante, David M. Sabatini

Cell, Journal Year: 2012, Volume and Issue: 149(2), P. 274 - 293

Published: April 1, 2012

Language: Английский

Citations

7796
mTOR Signaling in Growth, Metabolism, and Disease DOI Creative Commons
Robert A. Saxton, David M. Sabatini

Cell, Journal Year: 2017, Volume and Issue: 168(6), P. 960 - 976

Published: March 1, 2017

Language: Английский

Citations

6337
Fundamentals of cancer metabolism DOI Creative Commons
Ralph J. DeBerardinis, Navdeep S. Chandel

Science Advances, Journal Year: 2016, Volume and Issue: 2(5)

Published: May 6, 2016

Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.

Language: Английский

Citations

2518
mTOR at the nexus of nutrition, growth, ageing and disease DOI
Grace Y. Liu, David M. Sabatini

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(4), P. 183 - 203

Published: Jan. 14, 2020

Language: Английский

Citations

2082
Cellular Fatty Acid Metabolism and Cancer DOI Creative Commons

Erin Currie,

Almut Schulze, Rudolf Zechner

et al.

Cell Metabolism, Journal Year: 2013, Volume and Issue: 18(2), P. 153 - 161

Published: June 20, 2013

Language: Английский

Citations

1816
Energy Metabolism in the Liver DOI
Liangyou Rui

Comprehensive physiology, Journal Year: 2014, Volume and Issue: unknown, P. 177 - 197

Published: Jan. 10, 2014

The liver is an essential metabolic organ, and its function controlled by insulin other hormones. Glucose converted into pyruvate through glycolysis in the cytoplasm, subsequently oxidized mitochondria to generate ATP TCA cycle oxidative phosphorylation. In fed state, glycolytic products are used synthesize fatty acids de novo lipogenesis. Long-chain incorporated triacylglycerol, phospholipids, and/or cholesterol esters hepatocytes. These complex lipids stored lipid droplets membrane structures, or secreted circulation as very low-density lipoprotein particles. fasted secretes glucose both glycogenolysis gluconeogenesis. During pronged fasting, hepatic gluconeogenesis primary source for endogenous production. Fasting also promotes lipolysis adipose tissue, resulting release of nonesterified which ketone bodies though β-oxidation ketogenesis. Ketone provide a fuel extrahepatic tissues. Liver energy metabolism tightly regulated neuronal hormonal signals. sympathetic system stimulates, whereas parasympathetic suppresses, Insulin stimulates lipogenesis but suppresses gluconeogenesis, glucagon counteracts action. Numerous transcription factors coactivators, including CREB, FOXO1, ChREBP, SREBP, PGC-1α, CRTC2, control expression enzymes catalyze key steps pathways, thus controlling metabolism. Aberrant resistance, diabetes, nonalcoholic diseases. © 2014 American Physiological Society. Compr Physiol 4:177-197, 2014.

Language: Английский

Citations

1814
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB DOI
Carmine Settembre, Roberto Zoncu, Diego L. Medina

et al.

The EMBO Journal, Journal Year: 2012, Volume and Issue: 31(5), P. 1095 - 1108

Published: Feb. 17, 2012

Language: Английский

Citations

1734
Mechanisms and regulation of cholesterol homeostasis DOI
Jie Luo, Hongyuan Yang, Bao‐Liang Song

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 21(4), P. 225 - 245

Published: Dec. 17, 2019

Language: Английский

Citations

1430
The multifaceted roles of fatty acid synthesis in cancer DOI
Florian Röhrig, Almut Schulze

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(11), P. 732 - 749

Published: Sept. 23, 2016

Language: Английский

Citations

1294
Mechanisms and disease consequences of nonalcoholic fatty liver disease DOI Creative Commons
Rohit Loomba, Scott L. Friedman, Gerald I. Shulman

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(10), P. 2537 - 2564

Published: May 1, 2021

Language: Английский

Citations

1292