Mitochondria and Cancer

Cell, Journal Year: 2016, Volume and Issue: 166(3), P. 555 - 566

Published: July 1, 2016

Language: Английский

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The multifaceted contributions of mitochondria to cellular metabolism

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(7), P. 745 - 754

Published: June 22, 2018

Language: Английский

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The multifaceted roles of fatty acid synthesis in cancer

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(11), P. 732 - 749

Published: Sept. 23, 2016

Language: Английский

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Metabolic pathways promoting cancer cell survival and growth

Nature Cell Biology, Journal Year: 2015, Volume and Issue: 17(4), P. 351 - 359

Published: March 16, 2015

Language: Английский

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Reprogramming of fatty acid metabolism in cancer

British Journal of Cancer, Journal Year: 2019, Volume and Issue: 122(1), P. 4 - 22

Published: Dec. 10, 2019

Abstract A common feature of cancer cells is their ability to rewire metabolism sustain the production ATP and macromolecules needed for cell growth, division survival. In particular, importance altered fatty acid in has received renewed interest as, aside principal role as structural components membrane matrix, they are important secondary messengers, can also serve fuel sources energy production. this review, we will examine mechanisms through which with a focus on four main areas research. (1) The de novo synthesis exogenous uptake cellular pool acids. (2) molecular heterogeneity oncogenic signal transduction pathways, such PI3K–AKT–mTOR signalling, regulate metabolism. (3) acids essential mediators progression metastasis, remodelling tumour microenvironment. (4) Therapeutic strategies considerations successfully targeting cancer. Further research focusing complex interplay between signalling dysregulated holds great promise uncover novel metabolic vulnerabilities improve efficacy targeted therapies.

Language: Английский

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ROS homeostasis and metabolism: a dangerous liason in cancer cells

Cell Death and Disease, Journal Year: 2016, Volume and Issue: 7(6), P. e2253 - e2253

Published: June 9, 2016

Abstract Tumor cells harbor genetic alterations that promote a continuous and elevated production of reactive oxygen species. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate tumor growth in multiple ways by causing DNA damage genomic instability, ultimately, reprogramming cancer cell metabolism. This review outlines the metabolic-dependent mechanisms tumors engage when faced with are critical for progression producing redox cofactors. In particular, we describe how mitochondria has key role regulating interplay between homeostasis metabolism within cells. Last, will discuss potential therapeutic use agents directly or indirectly block

Language: Английский

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p53 in survival, death and metabolic health: a lifeguard with a licence to kill

Nature Reviews Molecular Cell Biology, Journal Year: 2015, Volume and Issue: 16(7), P. 393 - 405

Published: June 23, 2015

Language: Английский

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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(2), P. 194 - 208

Published: Jan. 20, 2020

Language: Английский

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Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

Developmental Cell, Journal Year: 2015, Volume and Issue: 32(6), P. 678 - 692

Published: March 1, 2015

Language: Английский

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The Acidic Tumor Microenvironment as a Driver of Cancer

Annual Review of Physiology, Journal Year: 2019, Volume and Issue: 82(1), P. 103 - 126

Published: Nov. 15, 2019

Acidic metabolic waste products accumulate in the tumor microenvironment because of high activity and insufficient perfusion. In tumors, acidity interstitial space relatively well-maintained intracellular pH influence cancer stromal cell function, their mutual interplay, interactions with extracellular matrix. Tumor is spatially temporally heterogeneous, fitness advantage cells adapted to likely particularly evident when they encounter less acidic regions, for instance, during invasion. Through complex effects on genetic stability, epigenetics, cellular metabolism, proliferation, survival, compartmentalized favors development. Cellular selection exacerbates malignant phenotype, which further enhanced by acid-induced motility, matrix degradation, attenuated immune responses, modified intercellular signaling. this review, we discuss how influences each stage development, from dysplasia full-blown metastatic disease.

Language: Английский

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