Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic DOI Creative Commons
Dick R. Nässel, Meet Zandawala, Tsuyoshi Kawada

et al.

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: Nov. 20, 2019

Tachykinins (TKs) are ancient neuropeptides present throughout the bilaterians and are, with some exceptions, characterized by a conserved FX1GX2Ramide carboxy terminus among protostomes FXGLMamide in deuterostomes. The best-known TK is vertebrate substance P, which mammals, together other TKs, has been implicated health disease important roles pain, inflammation, cancer, depressive disorder, immune system, gut function, hematopoiesis, sensory processing, hormone regulation. invertebrate TKs also known to have multiple functions central nervous system intestine these investigated more detail fly Drosophila arthropods. Here, we review protostome deuterostome organization evolution of precursors, peptides their receptors, as well functions, appear be partly across Bilateria. We outline distribution brains representative organisms. In Drosophila, recent studies revealed early olfactory neuromodulation circuits controlling locomotion food search, nociception, aggression, metabolic stress, release. signaling regulates lipid metabolism intestine. crustaceans, an neuromodulator rhythm-generating motor stomatogastric presynaptic modulator photoreceptor cells. Several additional functional can inferred from various brain circuits. addition, there few interesting cases where injected into prey animals vasodilators salivary glands or paralyzing agents venom glands. cases, produced predator sequences mimicking TKs. Lastly, TK-signaling appears duplicated Panarthropoda (comprising arthropods, onychophores, tardigrades) give rise novel type peptides, natalisins, distinct receptor. natalisins general, it that widely distributed act at short range neuromodulators cotransmitters.

Language: Английский

A Framework for Studying Emotions across Species DOI Creative Commons
David J. Anderson, Ralph Adolphs

Cell, Journal Year: 2014, Volume and Issue: 157(1), P. 187 - 200

Published: March 1, 2014

Language: Английский

Citations

597
Toward a Science of Computational Ethology DOI Creative Commons
David J. Anderson, Pietro Perona

Neuron, Journal Year: 2014, Volume and Issue: 84(1), P. 18 - 31

Published: Oct. 1, 2014

Language: Английский

Citations

480
Computational Neuroethology: A Call to Action DOI Creative Commons
Sandeep Robert Datta, David J. Anderson, Kristin Branson

et al.

Neuron, Journal Year: 2019, Volume and Issue: 104(1), P. 11 - 24

Published: Oct. 1, 2019

Language: Английский

Citations

392
Circuit modules linking internal states and social behaviour in flies and mice DOI
David J. Anderson

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(11), P. 692 - 704

Published: Oct. 18, 2016

Language: Английский

Citations

310
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior DOI
Dick R. Nässel, Meet Zandawala

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 179, P. 101607 - 101607

Published: March 22, 2019

Language: Английский

Citations

307
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress DOI Creative Commons
Moriel Zelikowsky, May Hui, Tomomi Karigo

et al.

Cell, Journal Year: 2018, Volume and Issue: 173(5), P. 1265 - 1279.e19

Published: May 1, 2018

Language: Английский

Citations

263
Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila DOI Creative Commons
E. Josephine Clowney,

Shinya Iguchi,

Jennifer J. Bussell

et al.

Neuron, Journal Year: 2015, Volume and Issue: 87(5), P. 1036 - 1049

Published: Aug. 13, 2015

Language: Английский

Citations

246
P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila DOI Creative Commons
Eric D. Hoopfer,

Yonil Jung,

H. Inagaki

et al.

eLife, Journal Year: 2015, Volume and Issue: 4

Published: Dec. 29, 2015

How brains are hardwired to produce aggressive behavior, and how aggression circuits related those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits enhanced both inter-male courtship. Genetic intersections revealed 8-10 P1 interneurons, previously thought exclusively control male were sufficient promote fighting. Optogenetic experiments indicated activation could at a threshold below required wing extension. the absence of extension triggered persistent via an internal state endure minutes. High-frequency promoted suppressed during photostimulation, whereas resumed was inhibited following photostimulation offset. Thus, neuron promotes latent, facilitates controls overt expression these social behaviors threshold-dependent, inverse manner.

Language: Английский

Citations

210
Neuropeptides as Regulators of Behavior in Insects DOI Open Access
Liliane Schoofs, Arnold De Loof, Matthias B. Van Hiel

et al.

Annual Review of Entomology, Journal Year: 2016, Volume and Issue: 62(1), P. 35 - 52

Published: Nov. 4, 2016

Neuropeptides are by far the largest and most diverse group of signaling molecules in multicellular organisms. They ancient important regulating a multitude processes. Their small proteinaceous character allowed them to evolve radiate quickly into numerous different molecules. On average, hundreds distinct neuropeptides present animals, sometimes with unique classes that do not occur distantly related species. Acting as neurotransmitters, neuromodulators, hormones, or growth factors, they extremely involved controlling growth, development, ecdysis, digestion, diuresis, many more physiological also crucial myriad behavioral actions associated feeding, courtship, sleep, learning memory, stress, addiction, social interactions. In general, behavior ensures an organism can survive its environment is defined any action change organism's relationship surroundings. Even though mode insects has been vigorously studied, relatively little known about only few model have investigated. Here, we provide overview roles play insect behavior. We conclude multiple need work concert coordinate certain behaviors. Additionally, studied date than single function.

Language: Английский

Citations

206
Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits DOI Creative Commons
Kang I. Ko, Cory M. Root, Scott A. Lindsay

et al.

eLife, Journal Year: 2015, Volume and Issue: 4

Published: July 24, 2015

The internal state of an organism influences its perception attractive or aversive stimuli and thus promotes adaptive behaviors that increase likelihood survival. mechanisms underlying these perceptual shifts are critical to our understanding how neural circuits support animal cognition behavior. Starved flies exhibit enhanced sensitivity odors reduced odors. Here, we show a functional remodeling the olfactory map is mediated by two parallel neuromodulatory systems act in opposing directions on attraction aversion at level first synapse. Short neuropeptide F sensitizes antennal lobe glomerulus wired for attraction, while tachykinin (DTK) suppresses activity aversion. Thus functionally reconfigure early processing optimize detection nutrients risk ignoring potentially toxic food resources.

Language: Английский

Citations

198