Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

PLoS Biology, Journal Year: 2015, Volume and Issue: 13(8), P. e1002226 - e1002226

Published: Aug. 18, 2015

Groundbreaking research on the universality and diversity of microorganisms is now challenging life sciences to upgrade fundamental theories that once seemed untouchable. To fully appreciate change field undergoing, one has place epochs foundational principles Darwin, Mendel, modern synthesis in light current advances are enabling a new vision for central importance microbiology. Animals plants no longer heralded as autonomous entities but rather biomolecular networks composed host plus its associated microbes, i.e., "holobionts." As such, their collective genomes forge "hologenome," models animal plant biology do not account these intergenomic associations incomplete. Here, we integrate concepts into historical contemporary visions summarize predictive refutable framework evaluation. Specifically, present ten clarify append what not, explain how they both support extend existing theory sciences, discuss potential ramifications multifaceted approaches zoology botany. We anticipate conceptual evidence-based foundation provided this essay will serve roadmap hypothesis-driven, experimentally validated holobionts hologenomes, thereby catalyzing continued fusion biology's subdisciplines. At time when symbiotic microbes recognized all aspects biology, holobiont hologenome afford holistic view biological complexity consistent with generally reductionist biology.

Language: Английский

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The microbiome in early life: implications for health outcomes

Nature Medicine, Journal Year: 2016, Volume and Issue: 22(7), P. 713 - 722

Published: July 1, 2016

Language: Английский

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Homeostatic Immunity and the Microbiota

Immunity, Journal Year: 2017, Volume and Issue: 46(4), P. 562 - 576

Published: April 1, 2017

Language: Английский

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Temporal and spatial variation of the human microbiota during pregnancy

Proceedings of the National Academy of Sciences, Journal Year: 2015, Volume and Issue: 112(35), P. 11060 - 11065

Published: Aug. 17, 2015

Significance The human indigenous microbial communities (microbiota) play critical roles in health and may be especially important for mother fetus during pregnancy. Using a case-control cohort of 40 women, we characterized weekly variation the vaginal, gut, oral microbiota after Microbiota membership remained relatively stable at each body site An altered vaginal community was associated with preterm birth; this finding corroborated by an analysis samples from additional nine women. We also discovered abrupt change delivery that persisted some cases least 1 y. Our findings suggest pregnancy outcomes might predicted features early gestation.

Language: Английский

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An insight into gut microbiota and its functionalities

Cellular and Molecular Life Sciences, Journal Year: 2018, Volume and Issue: 76(3), P. 473 - 493

Published: Oct. 13, 2018

Language: Английский

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