Liver International,
Journal Year:
2020,
Volume and Issue:
40(6), P. 1378 - 1394
Published: March 7, 2020
Abstract
Background
NASH
is
one
of
the
fastest
growing
liver
diseases
that
leads
to
severe
steatosis,
inflammation
and
ultimately
injury.
However,
pathophysiological
mechanisms
remain
unclear
pharmacological
treatment
against
disease
unavailable
currently.
Ferroptosis
a
non‐apoptotic
form
cell
death
induced
by
iron‐dependent
lipid
peroxidation.
Since
progression
accompanied
massive
accumulation,
which
generates
lipotoxic
species,
we
investigated
role
ferroptosis
in
progression.
Method
Mice
were
fed
on
MCD‐diet
mimic
gene
expression
was
analysed
RNA‐seq.
The
occurrence
hepatic
measured
ROS
level,
electron
microscopy
vivo
PI
staining.
beneficial
effects
inhibitors
evaluated
pathology
analysis.
mechanism
droplets
accumulation
vitro
culture.
Results
RNA‐seq
analysis
suggested
elevated
arachidonic
acid
metabolism
promotes
mouse
livers,
further
demonstrated
morphological
change
mitochondria
increased
death.
Iron
detected
serum
MCD‐fed
mice.
Scavenging
ferroptosis‐linked
peroxides
reduced
both
vitro.
Importantly,
alleviated
inflammation,
fibrogenesis
Finally,
steatosis
boosting
formation.
Conclusion
Our
results
demonstrate
an
important
suggest
may
serve
as
therapeutic
target
for
treatment.
Annual Review of Cell and Developmental Biology,
Journal Year:
2017,
Volume and Issue:
33(1), P. 491 - 510
Published: Aug. 10, 2017
Lipid
droplets
(LDs)
are
ubiquitous
organelles
that
store
neutral
lipids
for
energy
or
membrane
synthesis
and
act
as
hubs
metabolic
processes.
Cells
generate
LDs
de
novo,
converting
cells
to
emulsions
with
constituting
the
dispersed
oil
phase
in
aqueous
cytoplasm.
Here
we
review
our
current
view
of
LD
biogenesis.
We
present
a
model
formation
from
ER
distinct
steps
highlight
biology
proteins
govern
this
biophysical
process.
Areas
incomplete
knowledge
identified,
connections
physiology
diseases
linked
alterations
biology.
The Journal of Experimental Medicine,
Journal Year:
2021,
Volume and Issue:
218(6)
Published: May 12, 2021
Ferroptosis
is
a
type
of
regulated
necrosis
that
triggered
by
combination
iron
toxicity,
lipid
peroxidation,
and
plasma
membrane
damage.
The
upstream
inducers
ferroptosis
can
be
divided
into
two
categories
(biological
versus
chemical)
activate
major
pathways
(the
extrinsic/transporter
the
intrinsic/enzymatic
pathways).
Excessive
or
deficient
ferroptotic
cell
death
implicated
in
growing
list
physiological
pathophysiological
processes,
coupled
to
dysregulated
immune
response.
This
review
focuses
on
new
discoveries
related
how
cells
their
spilled
contents
shape
innate
adaptive
immunity
health
disease.
Understanding
immunological
characteristics
activity
not
only
illuminates
an
intersection
between
but
may
also
lead
development
novel
treatment
approaches
for
immunopathological
diseases.
