Regulation of antioxidants in cancer DOI Creative Commons
Fábio Hecht, Marco Zocchi,

Fatemeh Alimohammadi

et al.

Molecular Cell, Journal Year: 2023, Volume and Issue: 84(1), P. 23 - 33

Published: Nov. 28, 2023

Language: Английский

Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones DOI Creative Commons
Deguang Liang, Yan Feng, Fereshteh Zandkarimi

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(13), P. 2748 - 2764.e22

Published: June 1, 2023

Language: Английский

Citations

315
The cell biology of ferroptosis DOI
Scott J. Dixon, James A. Olzmann

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(6), P. 424 - 442

Published: Feb. 16, 2024

Language: Английский

Citations

271
ROS induced lipid peroxidation and their role in ferroptosis DOI Creative Commons
Hiwot Tezera Endale, Winta Tesfaye, Tiget Ayelgn Mengstie

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 1, 2023

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves oxidation lipids generate 4-hydroxynonenal other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation phospholipid bilayers. In order to offer novel ideas directions for investigation disorders connected these processes, we evaluate function which ultimately leads ferroptosis as well proposed crosstalk mechanisms between types programmed death.

Language: Английский

Citations

138
The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions DOI Open Access
Guang Lei, Li Zhuang, Boyi Gan

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(4), P. 513 - 534

Published: April 1, 2024

Language: Английский

Citations

116
Ferroptosis Detection: From Approaches to Applications DOI Open Access
Fantian Zeng,

Sureya Nijiati,

Longguang Tang

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(35)

Published: Feb. 25, 2023

Abstract Understanding the intricate molecular machinery that governs ferroptosis and leveraging this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, prognosis. Emerging approaches for in situ detection of major regulators biological events across cellular, tissue, living subjects provide a multiscale perspective studying ferroptosis. Furthermore, advanced applications integrate latest technologies hold tremendous promise research. In review, we first briefly summarize mechanisms key underlying Ferroptosis are then presented to delineate their design, action, applications. Special interest is placed on multifunctional platforms. Finally, discuss prospects challenges applications, with aim providing roadmap theranostic development broad range ferroptosis‐related diseases.

Language: Английский

Citations

115
Antioxidant Therapy in Cancer: Rationale and Progress DOI Creative Commons

Maochao Luo,

Li Zhou, Zhao Huang

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1128 - 1128

Published: June 8, 2022

Cancer is characterized by increased oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of metabolic disturbances signaling aberrations, can promote carcinogenesis malignant progression inducing gene mutations activating pro-oncogenic signaling, providing possible rationale for targeting stress in cancer treatment. While numerous antioxidants have demonstrated therapeutic potential, their clinical efficacy remains unproven. Here, we review the for, recent advances in, pre-clinical research on antioxidant therapy cancer, including with nonenzymatic antioxidants, such NRF2 activators, vitamins, N-acetylcysteine GSH esters, or enzymatic NOX inhibitors SOD mimics. In addition, will offer insights into prospective options improving effectiveness therapy, which may expand its applications

Language: Английский

Citations

112
Ferroptosis as a potential target for cancer therapy DOI Creative Commons
Zhen Chen, Weilong Wang, Siti Razila Abdul Razak

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 24, 2023

Abstract Ferroptosis is a recently discovered essential type of cell death that mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests ferroptosis double-edged sword in human cancer. However, the precise underlying molecular mechanisms their differential roles tumorigenesis are unclear. Therefore, this review, we summarize briefly present key pathways ferroptosis, paying special attention to regulation as well its dual role an oncogenic tumor suppressor event various cancers. Moreover, multiple pharmacological activators summarized, prospect targeting cancer therapy further elucidated.

Language: Английский

Citations

105
Autophagy mediates an amplification loop during ferroptosis DOI Creative Commons
Seung-Hee Lee, Narae Hwang, Byeong Geun Seok

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 25, 2023

Ferroptosis, a programmed cell death, has been identified and associated with cancer various other diseases. Ferroptosis is defined as reactive oxygen species (ROS)-dependent death related to iron accumulation lipid peroxidation, which different from apoptosis, necrosis, autophagy, forms of death. However, accumulating evidence revealed link between autophagy ferroptosis at the molecular level suggested that involved in regulating iron-dependent peroxidation ROS during ferroptosis. Understanding roles pathophysiological processes may provide effective strategies for treatment ferroptosis-related In this review, we summarize current knowledge regarding regulatory mechanisms underlying ferroptosis, including metabolism, its association pathway. addition, discuss contribution elucidate role enhancer ROS-dependent

Language: Английский

Citations

104
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis DOI Creative Commons
Baiyu Qiu, Fereshteh Zandkarimi,

Carla T. Bezjian

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(5), P. 1177 - 1190.e18

Published: Feb. 1, 2024

Language: Английский

Citations

104
Arachidonic acid metabolism in health and disease DOI Creative Commons
Yiran Zhang, Yingxiang Liu, Jin Sun

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Sept. 20, 2023

Arachidonic acid (AA), an n-6 essential fatty acid, is a major component of mammalian cells and can be released by phospholipase A2. Accumulating evidence indicates that AA plays biochemical roles, as it the direct precursor bioactive lipid metabolites eicosanoids such prostaglandins, leukotrienes, epoxyeicosatrienoic obtained from three distinct enzymatic metabolic pathways: cyclooxygenase pathway, lipoxygenase cytochrome P450 pathway. metabolism involved not only in cell differentiation, tissue development, organ function but also progression diseases, hepatic fibrosis, neurodegeneration, obesity, diabetes, cancers. These are generally considered proinflammatory molecules, they trigger oxidative stress stimulate immune response. Therefore, interventions pathways effective ways to manage inflammatory-related diseases clinic. Currently, inhibitors targeting enzymes related important area drug discovery. Moreover, many advances have been made clinical studies combination with chemotherapy immunotherapy. Herein, we review discovery focus on relation health diseases. Furthermore, summarized, potential applications discussed.

Language: Английский

Citations

94