Fundamentals of cancer metabolism

Science Advances, Journal Year: 2016, Volume and Issue: 2(5)

Published: May 6, 2016

Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.

Language: Английский

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Understanding the Intersections between Metabolism and Cancer Biology

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 657 - 669

Published: Feb. 1, 2017

Language: Английский

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From Krebs to clinic: glutamine metabolism to cancer therapy

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(10), P. 619 - 634

Published: July 29, 2016

Language: Английский

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Metabolic reprogramming and cancer progression

Science, Journal Year: 2020, Volume and Issue: 368(6487)

Published: April 9, 2020

Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but not yet resulted an effective anti therapeutic. In a Review, Faubert et al. discuss how changes develops from small, premalignant lesion to aggressive primary tumor and then metastasizes. Metabolic vulnerabilities likely change with progression, making the identification of general cancer-associated metabolic features difficult. The authors propose that more targeted approach tissues patients may be effective. Science , this issue p. eaaw5473

Language: Английский

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Glucose feeds the TCA cycle via circulating lactate

Nature, Journal Year: 2017, Volume and Issue: 551(7678), P. 115 - 118

Published: Oct. 18, 2017

Language: Английский

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Cancer metabolism: looking forward

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(10), P. 669 - 680

Published: July 16, 2021

Language: Английский

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Lactate Metabolism in Human Lung Tumors

Cell, Journal Year: 2017, Volume and Issue: 171(2), P. 358 - 371.e9

Published: Oct. 1, 2017

Language: Английский

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Mitochondrial metabolism and cancer

Cell Research, Journal Year: 2017, Volume and Issue: 28(3), P. 265 - 280

Published: Dec. 8, 2017

Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view instrumental development of powerful imaging tools that are still used clinics, it is now clear mitochondria play key role oncogenesis. Besides exerting central bioenergetic functions, provide indeed building blocks tumor anabolism, control redox calcium homeostasis, participate transcriptional regulation, govern cell death. Thus, constitute promising targets novel anticancer agents. However, tumors arise, progress, respond to therapy context an intimate crosstalk with host immune system, many immunological functions rely on intact mitochondrial metabolism. Here, we review cell-intrinsic cell-extrinsic mechanisms through which influence all steps oncogenesis, focus therapeutic potential targeting metabolism therapy.

Language: Английский

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Metabolic Instruction of Immunity

Cell, Journal Year: 2017, Volume and Issue: 169(4), P. 570 - 586

Published: May 1, 2017

Language: Английский

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The Science and Translation of Lactate Shuttle Theory

Cell Metabolism, Journal Year: 2018, Volume and Issue: 27(4), P. 757 - 785

Published: April 1, 2018

Language: Английский

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