Protein & Cell,
Journal Year:
2021,
Volume and Issue:
13(12), P. 877 - 919
Published: May 29, 2021
Abstract
Metabolic
rewiring
and
epigenetic
remodeling,
which
are
closely
linked
reciprocally
regulate
each
other,
among
the
well-known
cancer
hallmarks.
Recent
evidence
suggests
that
many
metabolites
serve
as
substrates
or
cofactors
of
chromatin-modifying
enzymes
a
consequence
translocation
spatial
regionalization
metabolites.
Various
metabolic
alterations
modifications
also
reportedly
drive
immune
escape
impede
immunosurveillance
within
certain
contexts,
playing
important
roles
in
tumor
progression.
In
this
review,
we
focus
on
how
reprogramming
cells
reshapes
alterations,
particular
acetylation
methylation
histone
proteins
DNA.
We
discuss
other
eminent
such
as,
succinylation,
hydroxybutyrylation,
lactylation,
update
current
advances
metabolism-
modification-based
therapeutic
prospects
cancer.
Science,
Journal Year:
2020,
Volume and Issue:
368(6487)
Published: April 9, 2020
Metabolism
as
cancer
progresses
Numerous
cancer-specific
alterations
in
metabolism
have
been
identified
but
not
yet
resulted
an
effective
anti
therapeutic.
In
a
Review,
Faubert
et
al.
discuss
how
changes
develops
from
small,
premalignant
lesion
to
aggressive
primary
tumor
and
then
metastasizes.
Metabolic
vulnerabilities
likely
change
with
progression,
making
the
identification
of
general
cancer-associated
metabolic
features
difficult.
The
authors
propose
that
more
targeted
approach
tissues
patients
may
be
effective.
Science
,
this
issue
p.
eaaw5473
Frontiers in Oncology,
Journal Year:
2019,
Volume and Issue:
9
Published: Nov. 1, 2019
Tumor
cells
must
generate
sufficient
ATP
and
biosynthetic
precursors
in
order
to
maintain
cell
proliferation
requirements.
Otto
Warburg
showed
that
tumor
uptake
high
amounts
of
glucose
producing
large
volumes
lactate
even
the
presence
oxygen,
this
process
is
known
as
"Warburg
effect
or
aerobic
glycolysis".
As
a
consequence
such
there
an
acidification
extracellular
pH
microenvironment,
ranging
between
6.0-6.5.
This
acidosis
favors
processes
metastasis,
angiogenesis
more
importantly,
immunosuppression,
which
has
been
associated
worse
clinical
prognosis.
Thus,
should
be
thought
important
oncometabolite
metabolic
reprogramming
cancer.
In
review,
we
summarized
role
regulating
microenvironment
cancer
discuss
its
relevance
up-regulation
enzymes
dehydrogenase
(LDH)
monocarboxilate
transporters
(MCTs)
tumors.
The
goal
review
expose
not
only
secondary
product
cellular
waste
cells,
but
also
key
molecule
involved
carcinogenesis
well
immune
evasion.
Finally,
possible
targeting
production
treatment
discussed.
