Movement Disorders, Journal Year: 2017, Volume and Issue: 32(5), P. 739 - 749
Published: Feb. 14, 2017
There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of microbiota could explain several features PD.
Language: Английский
Nature Reviews Disease Primers, Journal Year: 2017, Volume and Issue: 3(1)
Published: March 22, 2017
Language: Английский
Citations
3817
Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1877 - 2013
Published: Aug. 28, 2019
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric
Language: Английский
Citations
3429
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 16(8), P. 461 - 478
Published: May 23, 2019
Language: Английский
Citations
2188
The Lancet, Journal Year: 2021, Volume and Issue: 397(10291), P. 2284 - 2303
Published: April 11, 2021
Language: Английский
Citations
2162
Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11
Published: Jan. 31, 2020
A substantial body of evidence supports that the gut microbiota plays a pivotal role in regulation metabolic, endocrine and immune functions. In recent years, there has been growing recognition involvement modulation multiple neurochemical pathways through highly interconnected gut-brain axis. Although amazing scientific breakthroughs over last few years have expanded our knowledge on communication between microbes their hosts, underpinnings microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids (SCFAs), main metabolites produced colon by bacterial fermentation dietary fibers resistant starch, are speculated play key neuro-immunoendocrine regulation. However, underlying mechanisms which SCFAs might influence brain physiology behavior not fully elucidated. this review, we will outline current about interactions. We also highlight how development future treatments for central nervous system (CNS) disorders can take advantage intimate mutual interactions with exploring function.
Language: Английский
Citations
1942
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: April 23, 2022
Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.
Language: Английский
Citations
1557
Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(4), P. 241 - 255
Published: Oct. 22, 2020
Language: Английский
Citations
1451
Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(4), P. 219 - 232
Published: March 6, 2017
Language: Английский
Citations
1390
Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(10), P. 1359 - 1369
Published: Sept. 19, 2018
Language: Английский
Citations
1376
Brain Research, Journal Year: 2018, Volume and Issue: 1693, P. 128 - 133
Published: June 11, 2018
Language: Английский
Citations
1143