Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

European Journal of Immunology, Journal Year: 2019, Volume and Issue: 49(10), P. 1457 - 1973

Published: Oct. 1, 2019

These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed. Furthermore, tips, tricks pitfalls avoid, written peer-reviewed by leading experts field, making this an essential research companion.

Language: Английский

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Regulatory T Cells and Human Disease

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 541 - 566

Published: Feb. 4, 2020

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the transcription factor FoxP3 in nucleus and CD25 CTLA-4 on cell surface, are a functionally distinct subpopulation actively engaged maintenance of immunological self-tolerance homeostasis. Recent studies have facilitated our understanding cellular molecular basis their generation, function, phenotypic functional stability, adaptability. It is under investigation humans how or numerical Treg anomalies, whether genetically determined environmentally induced, contribute to diseases such as autoimmune diseases. Also being addressed Tregs can be targeted control physiological pathological immune responses, for example, by depleting them enhance tumor immunity expanding treat This review discusses current immunobiology normal disease states, with perspective realization Treg-targeting therapies clinic.

Language: Английский

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Regulatory T cells in autoimmune disease

Nature Immunology, Journal Year: 2018, Volume and Issue: 19(7), P. 665 - 673

Published: June 14, 2018

Language: Английский

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Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Immunity, Journal Year: 2019, Volume and Issue: 50(2), P. 302 - 316

Published: Feb. 1, 2019

Language: Английский

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Notch Signaling in the Tumor Microenvironment

Cancer Cell, Journal Year: 2018, Volume and Issue: 34(4), P. 536 - 548

Published: Aug. 23, 2018

Language: Английский

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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

Cell, Journal Year: 2018, Volume and Issue: 175(5), P. 1307 - 1320.e22

Published: Nov. 1, 2018

Language: Английский

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The immunological anatomy of the skin

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 19(1), P. 19 - 30

Published: Nov. 14, 2018

Language: Английский

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Hidradenitis suppurativa

Nature Reviews Disease Primers, Journal Year: 2020, Volume and Issue: 6(1)

Published: March 12, 2020

Language: Английский

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Helper T cell differentiation

Cellular and Molecular Immunology, Journal Year: 2019, Volume and Issue: 16(7), P. 634 - 643

Published: March 12, 2019

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Vitiligo: Mechanisms of Pathogenesis and Treatment

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 621 - 648

Published: Feb. 4, 2020

Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes and results in patches depigmentation are visible as white spots. Recent research studies have yielded a strong mechanistic understanding this disease. Autoreactive cytotoxic CD8 + T cells engage promote progression through local production IFN-γ, IFN-γ-induced chemokines then secreted from surrounding keratinocytes to further recruit positive-feedback loop. Both topical systemic treatments block IFN-γ signaling can effectively reverse vitiligo humans; however, relapse common after stopping treatments. resident memory responsible for relapse, new treatment strategies focus on eliminating these long-lasting benefit. Here, we discuss basic, translational, clinical provide insight into pathogenesis vitiligo, how has been utilized create targeted strategies.

Language: Английский

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