Cells,
Journal Year:
2021,
Volume and Issue:
10(7), P. 1794 - 1794
Published: July 15, 2021
Body
implants
and
implantable
medical
devices
have
dramatically
improved
prolonged
the
life
of
countless
patients.
However,
our
body
repair
mechanisms
evolved
to
isolate,
reject,
or
destroy
any
object
that
is
recognized
as
foreign
organism
inevitably
mounts
a
reaction
(FBR).
Depending
on
its
severity
chronicity,
FBR
can
impair
implant
performance
create
severe
clinical
complications
will
require
surgical
removal
and/or
replacement
faulty
device.
The
number
review
articles
discussing
seems
be
proportional
different
materials
applications
one
wonders,
what
else
there
tell?
We
here
take
position
fibrosis
researcher
(which,
coincidentally,
we
are)
elaborate
similarities
differences
between
FBR,
normal
wound
healing,
chronic
healing
conditions
result
in
development
peri-implant
fibrosis.
After
giving
credit
macrophages
inflammatory
phase
mainly
focus
activation
fibroblastic
cells
into
matrix-producing
highly
contractile
myofibroblasts.
While
has
been
discussed
consequence
disturbed
milieu
direct
myofibroblasts
at
surface
less
commonly
considered.
Thus,
provide
perspective
how
physical
properties
control
myofibroblast
actions
accumulation
stiff
scar
tissue.
Because
formation
tissue
around
major
reason
for
device
failure
extraction
surgeries,
providing
surfaces
with
myofibroblast-suppressing
features
first
step
enhance
acceptance
functional
lifetime.
Alternative
therapeutic
targets
are
elements
mechanotransduction
machinery
end
brief
overview
such
considered
treatment
other
organ
fibroses.
Science,
Journal Year:
2022,
Volume and Issue:
375(6576), P. 91 - 96
Published: Jan. 6, 2022
Fibrosis
affects
millions
of
people
with
cardiac
disease.
We
developed
a
therapeutic
approach
to
generate
transient
antifibrotic
chimeric
antigen
receptor
(CAR)
T
cells
in
vivo
by
delivering
modified
messenger
RNA
(mRNA)
cell–targeted
lipid
nanoparticles
(LNPs).
The
efficacy
these
vivo–reprogrammed
CAR
was
evaluated
injecting
CD5-targeted
LNPs
into
mouse
model
heart
failure.
Efficient
delivery
mRNA
encoding
the
lymphocytes
observed,
which
produced
transient,
effective
vivo.
Antifibrotic
exhibited
trogocytosis
and
retained
target
as
they
accumulated
spleen.
Treatment
mRNA-targeted
reduced
fibrosis
restored
function
after
injury.
In
generation
may
hold
promise
platform
treat
various
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Jan. 2, 2023
Abstract
Integrins
are
considered
the
main
cell-adhesion
transmembrane
receptors
that
play
multifaceted
roles
as
extracellular
matrix
(ECM)-cytoskeletal
linkers
and
transducers
in
biochemical
mechanical
signals
between
cells
their
environment
a
wide
range
of
states
health
diseases.
Integrin
functions
dependable
on
delicate
balance
active
inactive
status
via
multiple
mechanisms,
including
protein-protein
interactions,
conformational
changes,
trafficking.
Due
to
exposure
cell
surface
sensitivity
molecular
blockade,
integrins
have
been
investigated
pharmacological
targets
for
nearly
40
years,
but
given
complexity
sometimes
opposite
characteristics,
targeting
integrin
therapeutics
has
challenge.
To
date,
only
seven
drugs
successfully
marketed,
abciximab,
eptifibatide,
tirofiban,
natalizumab,
vedolizumab,
lifitegrast,
carotegrast.
Currently,
there
approximately
90
kinds
integrin-based
therapeutic
or
imaging
agents
clinical
studies,
small
molecules,
antibodies,
synthetic
mimic
peptides,
antibody–drug
conjugates
(ADCs),
chimeric
antigen
receptor
(CAR)
T-cell
therapy,
agents,
etc.
A
serious
lesson
from
past
drug
discovery
research
efforts
is
successes
rely
both
deep
understanding
integrin-regulatory
mechanisms
unmet
needs.
Herein,
we
provide
systematic
complete
review
all
family
members
integrin-mediated
downstream
signal
transduction
highlight
ongoing
develop
new
therapies/diagnoses
bench
clinic.
In
addition,
further
discuss
trend
development,
how
improve
success
rate
trials
therapies,
key
points
research,
basic
translational
research.
Science,
Journal Year:
2021,
Volume and Issue:
374(6571), P. 1070 - 1075
Published: Nov. 25, 2021
Inflammation
is
an
integral
part
of
animal
biology.
It
provides
critical
protection
from
adverse
environmental
factors
by
enforcing
the
defense
homeostasis
and
functional
structural
integrity
tissues
organs.
Recent
advances
have
uncovered
a
broad
range
biological
processes
that
involve
inflammatory
control,
calling
for
renewed
framework
inflammation
beyond
its
classical
roles
in
infection
injury.
In
this
Review,
new
perspectives
on
biology
are
discussed
research
directions
suggested
to
address
fundamental
gaps
our
current
understanding.
Science,
Journal Year:
2023,
Volume and Issue:
379(6633)
Published: Feb. 16, 2023
For
decades,
immunologists
have
studied
the
role
of
circulating
immune
cells
in
host
protection,
with
a
more
recent
appreciation
resident
within
tissue
microenvironment
and
intercommunication
between
nonhematopoietic
cells.
However,
extracellular
matrix
(ECM),
which
comprises
at
least
third
structures,
remains
relatively
underexplored
immunology.
Similarly,
biologists
often
overlook
regulation
complex
structural
matrices
by
system.
We
are
only
beginning
to
understand
scale
ECM
structures
determine
cell
localization
function.
Additionally,
we
need
better
how
dictate
complexity.
This
review
aims
highlight
potential
for
biological
discovery
interface
immunology
biology.
