Metabolic reprogramming and epigenetic modifications on the path to cancer DOI Creative Commons
Linchong Sun, Huafeng Zhang, Ping Gao

et al.

Protein & Cell, Journal Year: 2021, Volume and Issue: 13(12), P. 877 - 919

Published: May 29, 2021

Abstract Metabolic rewiring and epigenetic remodeling, which are closely linked reciprocally regulate each other, among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes a consequence translocation spatial regionalization metabolites. Various metabolic alterations modifications also reportedly drive immune escape impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how reprogramming cells reshapes alterations, particular acetylation methylation histone proteins DNA. We discuss other eminent such as, succinylation, hydroxybutyrylation, lactylation, update current advances metabolism- modification-based therapeutic prospects cancer.

Language: Английский

Mechanisms and Implications of Metabolic Heterogeneity in Cancer DOI Creative Commons
Jiyeon Kim, Ralph J. DeBerardinis

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(3), P. 434 - 446

Published: Sept. 1, 2019

Language: Английский

Citations

478
Monocarboxylate transporters in cancer DOI Creative Commons

Valéry L. Payen,

Erica Mina,

Vincent F. Van Hée

et al.

Molecular Metabolism, Journal Year: 2019, Volume and Issue: 33, P. 48 - 66

Published: July 27, 2019

Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different phenotypes. For energy production, may use 4 main fuels shuttled in 5 pathways. Glucose glycolysis be coupled to the tricarboxylic acid (TCA) cycle oxidative phosphorylation (OXPHOS) or lactic fermentation proliferating hypoxic cells. Lipids fuel lipolysis, glutamine glutaminolysis, lactate pathway lactate, all which TCA OXPHOS for production. This review focuses on latter pathway. Lactate, is prominently produced by glycolytic tumors, was only recently recognized as a major signaling agent. Its exchanges across membranes gated monocarboxylate transporters MCT1-4. summarizes current knowledge about MCT structure, regulation functions cancer, with specific focus metabolism, lactate-induced angiogenesis MCT-dependent metastasis. It also describes via cell surface receptor GPR81. Lactate MCTs, especially MCT1 MCT4, important contributors tumor aggressiveness. Analyses MCT-deficient (MCT+/- MCT−/-) animals (MCT-mutated) humans indicate they druggable, inhibitors being advanced development phase MCT4 still discovery phase. Imaging fluxes non-invasively using tracer positron emission tomography would further help identify responders treatments.

Language: Английский

Citations

463
Accumulation of succinate controls activation of adipose tissue thermogenesis DOI
Evanna L. Mills, Kerry A. Pierce,

Mark P. Jedrychowski

et al.

Nature, Journal Year: 2018, Volume and Issue: 560(7716), P. 102 - 106

Published: July 17, 2018

Language: Английский

Citations

462
Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS DOI Creative Commons
Weina Zhang, Guihua Wang, Zhigang Xu

et al.

Cell, Journal Year: 2019, Volume and Issue: 178(1), P. 176 - 189.e15

Published: May 30, 2019

Language: Английский

Citations

456
Metabolic reprogramming and epigenetic modifications on the path to cancer DOI Creative Commons
Linchong Sun, Huafeng Zhang, Ping Gao

et al.

Protein & Cell, Journal Year: 2021, Volume and Issue: 13(12), P. 877 - 919

Published: May 29, 2021

Abstract Metabolic rewiring and epigenetic remodeling, which are closely linked reciprocally regulate each other, among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes a consequence translocation spatial regionalization metabolites. Various metabolic alterations modifications also reportedly drive immune escape impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how reprogramming cells reshapes alterations, particular acetylation methylation histone proteins DNA. We discuss other eminent such as, succinylation, hydroxybutyrylation, lactylation, update current advances metabolism- modification-based therapeutic prospects cancer.

Language: Английский

Citations

438