Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(12), P. 4954 - 4967
Published: July 7, 2023
Abstract
Fast-spiking
parvalbumin
(PV)
interneurons
are
inhibitory
with
unique
morphological
and
functional
properties
that
allow
them
to
precisely
control
local
circuitry,
brain
networks
memory
processing.
Since
the
discovery
in
1987
PV
is
expressed
a
subset
of
fast-spiking
GABAergic
neurons,
our
knowledge
complex
molecular
physiological
these
cells
has
been
expanding.
In
this
review,
we
highlight
specific
neurons
fire
at
high
frequency
reliability,
enabling
network
oscillations
shape
encoding,
consolidation
retrieval
memories.
We
next
discuss
multiple
studies
reporting
neuron
impairment
as
critical
step
neuronal
dysfunction
cognitive
decline
mouse
models
Alzheimer’s
disease
(AD).
Finally,
propose
potential
mechanisms
underlying
AD
argue
early
changes
activity
could
be
causal
AD-associated
significant
contributor
pathogenesis.
Current Biology,
Journal Year:
2019,
Volume and Issue:
29(18), P. R890 - R905
Published: Sept. 1, 2019
Rhythms
are
a
fundamental
and
defining
feature
of
neuronal
activity
in
animals
including
humans.
This
rhythmic
brain
interacts
complex
ways
with
rhythms
the
internal
external
environment
through
phenomenon
'neuronal
entrainment',
which
is
attracting
increasing
attention
due
to
its
suggested
role
multitude
sensory
cognitive
processes.
Some
senses,
such
as
touch
vision,
sample
rhythmically,
while
others,
like
audition,
faced
mostly
inputs.
Entrainment
couples
events,
serving
fine-grained
routing
modulation
signals
across
multiple
spatial
temporal
hierarchies.
interaction
between
can
be
experimentally
investigated
even
modified
by
stimuli
or
invasive
non-invasive
neuromodulation
techniques.
We
provide
comprehensive
overview
topic
propose
theoretical
framework
how
entrainment
dynamically
structures
information
from
incoming
neuronal,
bodily
environmental
sources.
discuss
different
types
entrainment,
conceptual
advances
field,
converging
evidence
for
general
principles.
Frontiers in Neurology,
Journal Year:
2020,
Volume and Issue:
10
Published: Jan. 10, 2020
Alzheimer's
disease
(AD),
a
common
neurodegenerative
in
the
elderly
and
most
prevalent
cause
of
dementia,
is
characterized
by
progressive
cognitive
impairment.
The
prevalence
AD
continues
to
increase
worldwide,
becoming
great
healthcare
challenge
twenty-first
century.
In
more
than
110
years
since
was
discovered,
many
related
pathogenic
mechanisms
have
been
proposed,
recognized
hypotheses
are
amyloid
tau
hypotheses.
However,
almost
all
clinical
trials
targeting
these
not
identified
any
effective
methods
treat
AD.
Scientists
gradually
moving
away
from
simple
assumption,
as
proposed
original
hypothesis,
new
theories
pathogenesis,
including
gamma
oscillations,
prion
transmission,
cerebral
vasoconstriction,
growth
hormone
secretagogue
receptor
1α
(GHSR1α)-mediated
mechanism,
infection.
To
place
findings
context,
we
first
reviewed
neuropathology
further
discussed
insights
pathogenesis
Neuron,
Journal Year:
2020,
Volume and Issue:
108(3), P. 401 - 412
Published: Aug. 31, 2020
Epidemiological
studies
identify
midlife
hearing
loss
as
an
independent
risk
factor
for
dementia,
estimated
to
account
9%
of
cases.
We
evaluate
candidate
brain
bases
this
relationship.
These
include
a
common
pathology
affecting
the
ascending
auditory
pathway
and
multimodal
cortex,
depletion
cognitive
reserve
due
impoverished
listening
environment,
occupation
resources
when
in
difficult
conditions.
also
put
forward
alternate
mechanism,
drawing
on
new
insights
into
role
medial
temporal
lobe
cognition.
In
particular,
we
consider
how
aberrant
activity
service
pattern
analysis,
working
memory,
object
processing
may
interact
with
dementia
people
loss.
highlight
effect
interventions
depends
specific
mechanism
suggest
avenues
work
at
molecular,
neuronal,
systems
levels
pin
down.
Journal of Neuroscience,
Journal Year:
2021,
Volume and Issue:
41(37), P. 7698 - 7711
Published: Sept. 15, 2021
Throughout
the
body,
lymphatic
fluid
movement
supports
critical
functions
including
clearance
of
excess
and
metabolic
waste.
The
glymphatic
system
is
analog
in
CNS.
As
such,
plays
a
key
role
regulating
directional
interstitial
movement,
waste
clearance,
and,
potentially,
brain
immunity.
enables
bulk
CSF
from
subarachnoid
space
along
periarterial
spaces,
where
it
mixes
with
within
parenchyma
before
ultimately
exiting
via
perivenous
spaces.
This
review
focuses
on
important
questions
about
structure
this
system,
why
needs
transport
unexplored
aspects
transport.
We
provide
evidence
that
astrocytes
blood
vessels
determine
shape
perivascular
space,
controlling
fluid.
Glymphatic
has
potential
to
alter
local
as
well
global
signaling
molecules
metabolites.
also
highlight
for
cross
talk
among
cardiovascular
gastrointestinal
tract,
system.
Much
remains
be
studied,
but
we
propose
glymphatic/lymphatic
acts
cornerstone
between
body.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Nov. 22, 2019
Slow
gamma
oscillations
(30-60
Hz)
correlate
with
retrieval
of
spatial
memory.
Altered
slow
have
been
observed
in
Alzheimer's
disease.
Here,
we
use
the
J20-APP
AD
mouse
model
that
displays
memory
loss
as
well
reduced
amplitude
and
phase-amplitude
coupling
to
theta
phase.
To
restore
hippocampus,
used
optogenetics
activate
medial
septal
parvalbumin
neurons
at
different
frequencies.
We
show
optogenetic
stimulation
40
Hz
(but
not
80
restores
hippocampal
amplitude,
J20
model.
Restoration
during
rescued
mice
despite
significant
plaque
deposition.
These
results
support
role
suggest
could
provide
a
novel
strategy
for
treating
deficits
AD.
