Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

The Lancet, Journal Year: 2024, Volume and Issue: 404(10452), P. 572 - 628

Published: July 31, 2024

Language: Английский

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The Epidemiology of Alzheimer’s Disease Modifiable Risk Factors and Prevention

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2021, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 1, 2021

Mild Alzheimer’s disease is the leading cause of dementia, accounting for 50-70% cases. an irreversible neurodegenerative disease, which affects daily life activities and social functioning. As expectancy increases demographic ageing occurs, global prevalence expected to continue rise especially in developing countries, a costly burden disease. complex multifactorial disorder that determined by interaction genetic susceptibility environmental factors across course. Epidemiological studies have identified potential modifiable risk protective prevention. Moreover, considered start decades earlier before clinical symptoms occur, thus interventions targeting several non-demented elderly people even middle-aged population might prevent or delay onset. Here, we provide overview current epidemiological advances related factors, highlighting concept early

Language: Английский

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Hearing and dementia: from ears to brain

Brain, Journal Year: 2020, Volume and Issue: 144(2), P. 391 - 401

Published: Nov. 18, 2020

The association between hearing impairment and dementia has emerged as a major public health challenge, with significant opportunities for earlier diagnosis, treatment prevention. However, the nature of this not been defined. We hear our brains, particularly within complex soundscapes everyday life: neurodegenerative pathologies target auditory brain, are therefore predicted to damage function early profoundly. Here we present evidence proposition, based on structural functional features brain organization that confer vulnerability neurodegeneration, extensive, reciprocal interplay 'peripheral' 'central' dysfunction, recently characterized signatures canonical dementias (Alzheimer's disease, Lewy body disease frontotemporal dementia). Moving beyond any simple dichotomy ear argue reappraisal role cognitive dysfunction critical coupling peripheral organs in dementias. call clinical assessment real-world these diseases moves pure tone perception development novel 'cognitive stress tests' proximity markers diagnosis management strategies harness retained plasticity.

Language: Английский

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Association of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia

JAMA Neurology, Journal Year: 2022, Volume and Issue: 80(2), P. 134 - 134

Published: Dec. 5, 2022

Hearing loss is associated with cognitive decline. However, it unclear if hearing restorative devices may have a beneficial effect on cognition.To evaluate the associations of aids and cochlear implants decline dementia.PubMed, Embase, Cochrane databases for studies published from inception to July 23, 2021.Randomized clinical trials or observational as full-length articles in peer-reviewed journals relating interventions function, decline, impairment, dementia patients loss.The review was conducted accordance Preferred Reporting Items Systematic Review Meta-analyses (PRISMA) reporting guidelines. Two authors independently searched PubMed, loss.Maximally adjusted hazard ratios (HRs) were used dichotomous outcomes ratio means continuous outcomes. Sources heterogeneity investigated using sensitivity subgroup analyses, publication bias assessed visual inspection, Egger test, trim fill.A total 3243 screened; 31 (25 studies, 6 trials) 137 484 participants included, which 19 (15 4 included quantitative analyses. Meta-analysis 8 had 126 903 participants, follow-up duration ranging 2 25 years, studied long-term between aid use showed significantly lower hazards any among users compared uncorrected (HR, 0.81; 95% CI, 0.76-0.87; I2 = 0%). Additionally, meta-analysis 11 568 studying association restoration short-term test score changes revealed 3% improvement scores after (ratio means, 1.03; 1.02-1.04, 0%).In this meta-analysis, usage by 19% decrease Furthermore, these that general cognition short term. A benefit should be further randomized trials.

Language: Английский

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Hearing Loss and Cognition: What We Know and Where We Need to Go

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 28, 2022

Although a causal association remains to be determined, epidemiologic evidence suggests an between hearing loss and increased risk of dementia. If we determine the is causal, opportunity for targeted intervention may play fundamental role in dementia prevention. In this discussion, summarize current research on review potential casual mechanisms behind (e.g., sensory-deprivation hypothesis, information-degradation common cause). We emphasize key areas which might best inform our investigation association. These selected priorities include examination mechanism, measurement co-existing cognitive impairment determination any bias testing, managing prevention decline, or reduce dementia-related symptoms through management loss. Addressing these gaps how results are then translated clinical use prove paramount prevention, management, overall health older adults.

Language: Английский

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RETRACTED: Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort

The Lancet Public Health, Journal Year: 2023, Volume and Issue: 8(5), P. e329 - e338

Published: April 14, 2023

BackgroundDementia and hearing loss are both highly prevalent conditions among older adults. We aimed to examine the association between aid use risk of all-cause cause-specific dementia middle-aged older-aged adults, explore roles mediators moderators in their association.MethodsWe used data from UK Biobank, a population-based cohort study, which recruited adults aged 40–69 years 2006 2010 across 22 centres England, Scotland, Wales. Cox proportional hazards models estimate hazard ratios (HRs) 95% CIs self-reported status (hearing with or without aids) at baseline (all-cause dementia, Alzheimer's disease, vascular non-Alzheimer's disease non-vascular dementia). Dementia diagnoses were ascertained using hospital records death-register data. also analysed (self-reported social isolation, loneliness, mood) education income, smoking, morbidity, measured APOE allele status).FindingsAfter exclusion people who did not answer question on difficulties (n=25 081 [5·0%]) those visit (n=283 [0·1%]), we included 437 704 analyses. Compared participants loss, aids had an increased (HR 1·42 [95% CI 1·29–1·56]); found no (1·04 [0·98–1·10]). The positive was observed subtypes (Alzheimer's attributable proportion for estimated be 29·6%. Of total 1·5% mediated by reducing 2·3% 7·1% depressed mood.InterpretationIn is associated similar level that loss. With postulation up 8% cases could prevented proper management, our findings highlight urgent need take measures address improve cognitive decline.FundingNational Natural Science Foundation China Shandong Province, Taishan Scholars Project, Medical Board, Postdoctoral Foundation.

Language: Английский

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Hearing Loss, Hearing Aid Use, and Risk of Dementia in Older Adults

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: 150(2), P. 157 - 157

Published: Jan. 4, 2024

Hearing loss has been suggested as a risk factor for dementia, but there is still need high-quality research to better understand the association between these 2 conditions and underlying causal mechanisms treatment benefits using larger cohorts detailed data.

Language: Английский

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Role of Oxidative Stress in Sensorineural Hearing Loss

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4146 - 4146

Published: April 9, 2024

Hearing is essential for communication, and its loss can cause a serious disruption to one’s social life. also recognized as major risk factor dementia; therefore, addressing hearing pressing global issue. Sensorineural loss, the predominant type of mainly due damage inner ear along with variety pathologies including ischemia, noise, trauma, aging, ototoxic drugs. In addition genetic factors, oxidative stress has been identified common mechanism underlying several cochlear pathologies. The cochlea, which plays role in auditory function, requires high-energy metabolism is, highly susceptible stress, particularly mitochondria. Based on these pathological findings, potential antioxidants treatment demonstrated animal studies. However, results from human studies are insufficient, future clinical trials required. This review discusses relationship between sensorineural reactive species (ROS), particular emphasis age-related noise-induced ischemia–reperfusion injury. mechanisms, current status perspectives ROS-targeted therapy described.

Language: Английский

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Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology

EBioMedicine, Journal Year: 2022, Volume and Issue: 86, P. 104336 - 104336

Published: Nov. 7, 2022

Language: Английский

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Crossmodal plasticity in hearing loss

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(5), P. 377 - 393

Published: March 27, 2023

Crossmodal plasticity is a textbook example of the ability brain to reorganize based on use. We review evidence from auditory system showing that such reorganization has significant limits, dependent pre-existing circuitry and top-down interactions, extensive often absent. argue does not support hypothesis crossmodal responsible for closing critical periods in deafness, instead represents neuronal process dynamically adaptable. evaluate changes both developmental adult-onset which start as early mild-moderate hearing loss show reversibility when restored. Finally, appear affect preconditions successful restoration. Given its dynamic versatile nature, we describe how this can be exploited improving clinical outcomes after neurosensory

Language: Английский

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