Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(7), P. 3224 - 3252
Published: Jan. 1, 2024
Neoantigens
play
a
pivotal
role
in
the
field
of
tumour
therapy,
encompassing
stimulation
anti-tumour
immune
response
and
enhancement
targeting
capability.
Nonetheless,
numerous
factors
directly
influence
effectiveness
neoantigens
bolstering
responses,
including
neoantigen
quantity
specificity,
uptake
rates
by
antigen-presenting
cells
(APCs),
residence
duration
within
microenvironment
(TME),
their
ability
to
facilitate
maturation
APCs
for
activation.
Nanotechnology
assumes
significant
several
aspects,
facilitating
release,
promoting
delivery
cells,
augmenting
dendritic
shielding
from
protease
degradation,
optimizing
interactions
between
system.
Consequently,
development
nanotechnology
synergistically
enhances
efficacy
cancer
theranostics.
In
this
review,
we
provide
an
overview
sources,
mechanisms
neoantigen-induced
evolution
precision
neoantigen-based
nanomedicine.
This
encompasses
various
therapeutic
modalities,
such
as
immunotherapy,
phototherapy,
radiotherapy,
chemotherapy,
chemodynamic
other
strategies
tailored
augment
therapeutics.
We
also
discuss
current
challenges
prospects
application
nanomedicine,
aiming
expedite
its
clinical
translation.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Jan. 6, 2023
Abstract
Recent
advances
in
neoantigen
research
have
accelerated
the
development
and
regulatory
approval
of
tumor
immunotherapies,
including
cancer
vaccines,
adoptive
cell
therapy
antibody-based
therapies,
especially
for
solid
tumors.
Neoantigens
are
newly
formed
antigens
generated
by
cells
as
a
result
various
tumor-specific
alterations,
such
genomic
mutation,
dysregulated
RNA
splicing,
disordered
post-translational
modification,
integrated
viral
open
reading
frames.
recognized
non-self
trigger
an
immune
response
that
is
not
subject
to
central
peripheral
tolerance.
The
quick
identification
prediction
neoantigens
been
made
possible
advanced
next-generation
sequencing
bioinformatic
technologies.
Compared
tumor-associated
antigens,
highly
immunogenic
provide
emerging
targets
personalized
serve
prospective
predictors
survival
prognosis
checkpoint
blockade
responses.
therapies
will
be
aided
understanding
mechanism
underlying
neoantigen-induced
anti-tumor
streamlining
process
neoantigen-based
immunotherapies.
This
review
provides
overview
on
characterization
outlines
clinical
applications
immunotherapeutic
strategies
based
neoantigens.
We
also
explore
their
current
status,
inherent
challenges,
translation
potential.
Cell,
Journal Year:
2023,
Volume and Issue:
186(23), P. 5068 - 5083.e23
Published: Oct. 6, 2023
Metabolic
reprogramming
is
a
hallmark
of
cancer.
However,
mechanisms
underlying
metabolic
and
how
altered
metabolism
in
turn
enhances
tumorigenicity
are
poorly
understood.
Here,
we
report
that
arginine
levels
elevated
murine
patient
hepatocellular
carcinoma
(HCC),
despite
reduced
expression
synthesis
genes.
Tumor
cells
accumulate
high
due
to
increased
uptake
arginine-to-polyamine
conversion.
Importantly,
the
promote
tumor
formation
via
further
reprogramming,
including
changes
glucose,
amino
acid,
nucleotide,
fatty
acid
metabolism.
Mechanistically,
binds
RNA-binding
motif
protein
39
(RBM39)
control
RBM39-mediated
upregulation
asparagine
leads
enhanced
uptake,
creating
positive
feedback
loop
sustain
oncogenic
Thus,
second
messenger-like
molecule
reprograms
growth.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(10), P. 4025 - 4059
Published: June 30, 2023
Antibody‒drug
conjugates
(ADCs),
which
combine
the
advantages
of
monoclonal
antibodies
with
precise
targeting
and
payloads
efficient
killing,
show
great
clinical
therapeutic
value.
The
ADCs'
play
a
key
role
in
determining
efficacy
ADC
drugs
thus
have
attracted
attention
field.
An
ideal
payload
should
possess
sufficient
toxicity,
low
immunogenicity,
high
stability,
modifiable
functional
groups.
Common
include
tubulin
inhibitors
DNA
damaging
agents,
accounting
for
more
than
half
development.
However,
due
to
limitations
traditional
payloads,
such
as
inadequate
development
acquired
drug
resistance,
novel
highly
diverse
targets
reduced
side
effects
are
being
developed.
This
perspective
summarizes
recent
research
advances
main
focuses
on
structure-activity
relationship
studies,
co-crystal
structures,
designing
strategies,
further
discusses
future
directions
payloads.
review
also
aims
provide
valuable
references
that
will
efficacy,
adequate
abilities
overcome
resistance.
