Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 923 - 923
Published: April 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 19, 2025
In
recent
years,
researchers
have
examined
the
use
of
polyunsaturated
fatty
acids
(PUFA)
or
a
low
omega-6/3
ratio
to
protect
knee
joint.
The
current
study
is
based
on
genome-wide
association
(GWAS)
analysis
and
uses
Mendelian
randomization
(MR)
method
evaluate
effect
total
PUFA,
omega-3,
omega-6,
ratios
osteoarthritis
(OA).
First,
we
downloaded
latest
PUFA
OA
GWAS
data.
data
were
divided
into
four
groups:
ratios.
split
nine
hip
(total,
males,
females),
hand
females).
Then,
qualified
SNPs
selected
as
instrumental
variables.
Inverse
variance
weighting
(IVW),
weighted
median,
MR‒Egger
used
for
MR
analysis.
Finally,
MR‒Egger,
MR-Presso,
Cochran's
Q
statistical
methods
heterogeneity
pleiotropy.
Thirty-six
IVW
results
showed
that
did
not
significantly
increase
decrease
risk
knee,
hip,
OA.
(male
female)
follows:
PUFA-knee
(OR:
0.97,
95%
CI:
0.92–1.02,
P
=
0.283);
PUFA-hip
1.01,
0.93–1.08,
0.806);
PUFA-hand
0.99,
0.91–1.07,
0.896).
There
was
no
obvious
horizontal
polytropy
in
all
analyses,
there
some
analyses.
Our
does
indicate
mega-3,
are
helpful
people
with
OA,
nor
it
omega-6
increases
dietary
management
patients
needs
be
performed
cautiously.
Neuropsychiatric Disease and Treatment,
Journal Year:
2022,
Volume and Issue:
Volume 18, P. 375 - 389
Published: Feb. 1, 2022
Abstract:
Depression,
one
of
the
most
common
comorbidities
with
osteoarthritis
(OA),
affects
patient
prognosis
and
quality
life.
It
also
increases
overall
burden
disease.
This
subgroup
patients
has
not
been
effectively
managed
in
clinical
settings.
The
study
aimed
to
direct
physicians'
attention
co-occurrence
depression
OA.
Therefore,
this
review
summarizes
relevant
literature
published
over
past
10
years.
focus
is
on
prevalence
risk
factors
for
OA,
effects
OA
development
treatment
response,
comorbidity
mechanisms,
screening,
non-pharmacological
treatment.
research
etiology
driven
largely
by
epidemiological
studies.
Recent
studies
have
shown
that
high
levels
pain,
poor
function,
numbers
sites,
slow
gait
might
be
associated
depression.
However,
pathophysiology
remains
unclear.
In
addition
immune
inflammation
structural
changes
brain,
which
documented
brain
imaging
studies,
psychosocial
may
play
a
role.
evidence
indicates
can
treated
early
intervention;
however,
adjustments
need
made
individuals
comorbid
recommended
health
care
providers
pay
more
depressive
symptoms
Clinicians
should
develop
implement
an
individualized
comprehensive
plan
based
mental
assessment
teams
other
professionals
optimize
outcomes.
Keywords:
osteoarthritis,
depression,
epidemiology,
prognosis,
A
Letter
Editor
article.
Cell Genomics,
Journal Year:
2022,
Volume and Issue:
2(11), P. 100195 - 100195
Published: Oct. 12, 2022
Proteome-wide
Mendelian
randomization
(MR)
shows
value
in
prioritizing
drug
targets
Europeans
but
with
limited
evidence
other
ancestries.
Here,
we
present
a
multi-ancestry
proteome-wide
MR
analysis
based
on
cross-population
data
from
the
Global
Biobank
Meta-analysis
Initiative
(GBMI).
We
estimated
putative
causal
effects
of
1,545
proteins
eight
diseases
African
(32,658)
and
European
(1,219,993)
ancestries
identified
45
7
protein-disease
pairs
genetic
colocalization
two
ancestries,
respectively.
A
comparison
both
seven
specific
separately.
Integrating
these
signals
clinical
trial
evidence,
prioritized
16
for
investigation
future
trials.
Our
results
highlight
informing
generalizability
disease
prevention
across
illustrate
meta-analysis
biobanks
development.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(46)
Published: Sept. 7, 2022
Abstract
Osteoarthritis
is
a
chronic
inflammatory
disease
characterized
by
cartilage
degeneration.
Anti‐inflammatory
therapy
has
limited
effects,
and
effective
reduction
of
wear
through
lubrication
essential.
In
vivo
stability
lubricity
commercial
lubricants
are
insufficient,
leading
to
failure
lubricating
treatment
progression
osteoarthritis.
To
address
these
issues,
new
therapeutic
methods
combining
anti‐inflammation
stable
high‐performance
developed.
Inspired
the
sliding
mechanism
snowboards,
“nano‐snowboard”
modifying
molybdenum
disulfide
(MoS
2
)
with
biomimetic
phospholipid
polymer
poly
(dopamine
methacrylamide‐co‐2‐methacryloyloxyethyl
phosphorylcholine)
(PDMPC)
loading
anti‐inflammatory
drug
diclofenac
sodium
(DS),
namely
MoS
‐PDMPC‐DS,
been
synthesized.
2D
layered
structure
photothermal
properties,
serves
as
solid
lubricant
carrier.
Meanwhile,
modification
PDMPC
on
surface
MOS
avoids
oxidative
denaturation
in
physiological
environment,
forming
solid–liquid
composite
improving
joint
cavity.
vitro
experiments
show
that
‐PDMPC‐DS
can
stay
cavity
for
more
than
one
week
exert
long‐lasting
effects
treat
osteoarthritis
effectively.
This
nano‐snowboard
provides
idea
synergistic
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 6003 - 6003
Published: May 26, 2022
The
extracellular
matrix
(ECM)
has
long
been
regarded
as
a
packing
material;
supporting
cells
within
the
tissue
and
providing
tensile
strength
protection
from
mechanical
stress.
There
is
little
surprise
when
one
considers
dynamic
nature
of
many
individual
proteins
that
contribute
to
ECM,
we
are
beginning
appreciate
more
nuanced
role
for
ECM
in
homeostasis
disease.
Articular
cartilage
adapted
be
able
perceive
respond
load.
Indeed,
physiological
loads
essential
maintain
thickness
healthy
joint
excessive
stress
associated
with
breakdown
seen
osteoarthritis
(OA).
Although
trigger
by
which
increased
drives
catabolic
pathways
remains
unknown,
mechanism
responds
compressive
load
release
growth
factors
sequestered
pericellular
matrix.
These
heparan
sulfate-bound
appear
largely
chondroprotective
displaced
an
aggrecan-dependent
sodium
flux.
Emerging
evidence
suggests
released
act
coordinated
fashion
drive
repair.
Thus,
key
mechano-sensor
mechano-effector
cartilage,
responsible
directing
subsequent
cellular
events
relevance
health
Drug Design Development and Therapy,
Journal Year:
2022,
Volume and Issue:
Volume 16, P. 1311 - 1347
Published: May 1, 2022
Abstract:
Drug
delivery
for
osteoarthritis
(OA)
treatment
is
a
continuous
challenge
because
of
their
poor
bioavailability
and
rapid
clearance
in
joints.
Intra-articular
(IA)
drug
common
strategy
its
therapeutic
effects
depend
mainly
on
the
efficacy
drug-delivery
system
used
OA
therapy.
Different
types
IA
systems,
such
as
microspheres,
nanoparticles,
hydrogels,
have
been
rapidly
developed
over
past
decade
to
improve
effects.
With
advancement
mechanism
research,
new
drugs
targeting
specific
cell/signaling
pathways
are
evolving
effective
critical
treating
OA.
In
this
review,
recent
advances
various
systems
treatment,
targeted
strategies,
related
signaling
summarized
analyzed
based
current
publications.
Keywords:
osteoarthritis,
knee,
delivery,
intra-articular
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Feb. 2, 2022
Back
pain
is
a
common
and
debilitating
disorder
with
largely
unknown
underlying
biology.
Here
we
report
genome-wide
association
study
of
back
using
diagnoses
assigned
in
clinical
practice;
dorsalgia
(119,100
cases,
909,847
controls)
intervertebral
disc
(IDD)
(58,854
922,958
controls).
We
identify
41
variants
at
33
loci.
The
most
significant
(OR
