Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(44)

Published: July 17, 2023

Abstract Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are limited to unilateral efforts in lubrication, inhibition of inflammation, free radicals scavenging, and cartilage regeneration. Herein, by modifying molybdenum disulfide (MoS 2 ) with Mg 2+ ‐doped polydopamine coating polysulfobetaines, a dual‐bionic photothermal nanozyme (MPMP) constructed mimic antioxidases/hyaluronan synthase OA therapy. Photothermally enhanced lubrication lowers the coefficient friction (0.028) early stage treatment. The antioxidases‐mimicking properties MPMP contribute eliminating reactive oxygen nitrogen species (ROS/RNS) (over 90% scavenging ratio H O /·OH/O · – /DPPH/ABTS + supplying . With NIR irradiation, triggers thermogenesis (upregulating HSP70 expression) release, which promotes chondrogenesis inflammatory conditions deactivating NF‐κB/IL‐17 signaling pathways enhancing MAPK pathway. Benefiting from , MPMP‐NIR shows HAS‐mimicking activity increase intracellular (twofold) extracellular (3.12‐fold) HA production. Therefore, demonstrates superior spatiotemporally therapeutic effect on mice model, terms osteophytes (83.41% reduction), OARSI scores (88.57% ACAN expression (2.70‐fold increment). Hence, insights into nanozymes can be promising strategy therapy or other inflammation‐related diseases.

Language: Английский

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Magnetic Polysaccharide Mesenchymal Stem Cells Exosomes Delivery Microcarriers for Synergistic Therapy of Osteoarthritis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20101 - 20110

Published: July 23, 2024

Osteoarthritis (OA) is a prevalent degenerative disease that afflicts more than 250 million people worldwide, impairing their mobility and quality of life. However, conventional drug therapy palliative. Exosomes (Exo), although with the potential to fundamentally repair cartilage, face challenges in efficient enrichment delivery. In this study, we developed magnetic polysaccharide hydrogel particles as microcarriers for synergistic OA. The were composed modified natural polysaccharides, hyaluronic acid (HAMA), chondroitin sulfate (CSMA), generated from microfluidic electrospray combination cryogelation process. Magnetic nanoparticles spiny structures capable capturing stem cell Exo encapsulated within together an anti-inflammatory diclofenac sodium (DS). released DS had effect alleviating OA symptoms promoting cartilage repair. vitro vivo results demonstrated excellent performance microcarrier treatment. We believe work has other related diseases.

Language: Английский

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A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(7), P. 2554 - 2567

Published: Jan. 1, 2023

It is found that a cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system can effectively treat early OA through synergistic lubrication, dual-drug sequence controlled release, and anti-inflammation.

Language: Английский

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A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(12)

Published: Jan. 28, 2023

Abstract Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response joint capsule. Synergistic therapy combining anti‐inflammation emerges as a novel treatment OA. In this study, bioinspired by ultralow friction natural synovial fluid mussel adhesion chemistry, biomimetic nanosystem dual functions enhanced stimuli‐responsive drug release developed. A dopamine mediated strategy realizes one step grafting hyaluronic acid (HA) on fluorinated graphene. The polymer modified sheets exhibit highly efficient near‐infrared absorption, show steady long time under various working conditions, in which the coefficient reduced 75% compared to H 2 O. Diclofenac sodium (DS) high loading capacity 29.2% controllably loaded, responsive sustained adjusted light. Cell experiments reveal that lubricating taken up endocytosis, results confirm inhibits osteoarthritis deterioration upregulating anabolic gene downregulating catabolic proteases pain‐related gene. This work proposes promising approach integrate graphene dual‐functional for effective synergistic

Language: Английский

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Meniscus-Inspired Self-Lubricating and Friction-Responsive Hydrogels for Protecting Articular Cartilage and Improving Exercise

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 24308 - 24319

Published: Nov. 17, 2023

Meniscus injuries are associated with the degeneration of cartilage and development osteoarthritis (OA). It is challenging to protect articular improve exercise when a meniscus injury occurs. Herein, inspired by components functions meniscus, we developed self-lubricating friction-responsive hydrogel that contains nanoliposomes loaded diclofenac sodium (DS) Kartogenin (KGN) for anti-inflammation regeneration. When was injected into site, drug-loaded were released from in manner reassembled form hydration layers lubricate joints during movement. Meanwhile, DS KNG constantly mitigate inflammation promote Additionally, this exhibited favorable injectability, mechanical properties, fatigue resistance, prolonged degradation. In vivo experiments demonstrated injection effectively improved performance protected rats, suggesting it as potential therapeutic approach meniscal injuries.

Language: Английский

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Stem cell recruitment polypeptide hydrogel microcarriers with exosome delivery for osteoarthritis treatment

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 27, 2024

With the accelerated aging tendency, osteoarthritis (OA) has become an intractable global public health challenge. Stem cells and their derivative exosome (Exo) have shown great potential in OA treatment. Research this area tends to develop functional microcarriers for stem cell Exo delivery improve therapeutic effect. Herein, we a novel system of Exo-encapsulated cell-recruitment hydrogel from liquid nitrogen-assisted microfluidic electrospray Benefited advanced droplet generation capability microfluidics mild cryogelation procedure, resultant particles show uniform size dispersion excellent biocompatibility. Moreover, acryloylated recruitment peptides SKPPGTSS are directly crosslinked within by ultraviolet irradiation, thus simplifying peptide coupling process preventing its premature release. The SKPPGTSS-modified can recruit endogenous promote cartilage repair released further enhances performance through synergistic effects. These features suggest that proposed microcarrier is promising candidate

Language: Английский

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Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: May 1, 2024

Abstract Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting progression. This review illuminates novel approaches OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural lubrication, show promise restoring biomechanics and alleviating pain. delves into an array biomimetic lubricants, including polymer brush, nanocomposite hydrogel, nanoparticles, underscoring their roles anti‐inflammation, targeting, cartilage repair, drug delivery. Furthermore, the potential mesenchymal stem cells differentiate chondrocytes, coupled with delivery these exosomes via nanomaterials, has promoted cell therapy avenues for OA. also highlights function non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, antisense oligonucleotides impeding progression, nanomaterials facilitating delivery, thus advanced therapeutic possibilities immune evasion bone proliferation. Overall, this encapsulates evolution treatment from material cell, ultimately gene forecasting future where evolve toward integrated, personalized diagnostics therapeutics

Language: Английский

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Kirigami triboelectric spider fibroin microneedle patches for comprehensive joint management

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101044 - 101044

Published: April 4, 2024

Joint injuries are among the leading causes of disability. Present concentrations were focused on oral drugs and surgical treatment, which brings severe unnecessary difficulties for patients. Smart patches with high flexibility intelligent drug control-release capacity greatly desirable efficient joint management. Herein, we present a novel

Language: Английский

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The lubricated matter in body

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 146, P. 101334 - 101334

Published: July 2, 2024

Language: Английский

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