Choroid plexus mast cells drive tumor-associated hydrocephalus DOI Creative Commons

Yiye Li,

Can Di,

Shi‐Jian Song

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(26), P. 5719 - 5738.e28

Published: Dec. 1, 2023

Language: Английский

Metastasis DOI Creative Commons

Stefanie Gerstberger,

Qingwen Jiang, Karuna Ganesh

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

Citations

357
The biology of TREM receptors DOI Open Access
Marco Colonna

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(9), P. 580 - 594

Published: Feb. 7, 2023

Language: Английский

Citations

185
Therapeutic targeting of tumour myeloid cells DOI
Simon T. Barry, Dmitry I. Gabrilovich, Owen J. Sansom

et al.

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(4), P. 216 - 237

Published: Feb. 6, 2023

Language: Английский

Citations

152
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis DOI Creative Commons
Jana Biermann, Johannes C. Melms, Amit Dipak Amin

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(14), P. 2591 - 2608.e30

Published: July 1, 2022

Language: Английский

Citations

124
The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis DOI Creative Commons
Qi Zhang, Rober Abdo, Cristiana Iosef

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 10, 2022

Brain metastases (BrMs) are a common occurrence in lung cancer with dismal outcome. To understand the mechanism of metastasis to inform prognosis and treatment, here we analyze primary metastasized tumor specimens from 44 non-small cell patients by spatial RNA sequencing, affording whole transcriptome map resolved morphological markers for core, immune microenvironment (TIME), brain (TBME). Our data indicate that (TME) brain, including TIME TBME, undergoes extensive remodeling create an immunosuppressive fibrogenic niche BrMs. Specifically, TME is characterized reduced antigen presentation B/T function, increased neutrophils M2-type macrophages, immature microglia, reactive astrocytes. Differential gene expression network analysis identify fibrosis regulation as major functional modules disrupted both TME. Besides providing systems-level insights into metastasis, our study uncovers potential prognostic biomarkers suggests therapeutic strategies should be tailored status

Language: Английский

Citations

108
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity DOI
Ryan C. Gimple, Kailin Yang,

Matthew Halbert

et al.

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(9), P. 497 - 514

Published: June 16, 2022

Language: Английский

Citations

87
Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes DOI Creative Commons
Zhongshan Shi, Pei Yu, Wei‐Jye Lin

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(5), P. 696 - 710.e9

Published: Jan. 5, 2023

Language: Английский

Citations

86
The local microenvironment drives activation of neutrophils in human brain tumors DOI Creative Commons
Roeltje R. Maas, Klara Soukup, Nadine Fournier

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(21), P. 4546 - 4566.e27

Published: Sept. 27, 2023

Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors substantial numbers. However, their precise functions different cancer types remain incompletely understood, including brain microenvironment. We therefore investigated neutrophils tumor tissue of glioma metastasis patients, with matched peripheral blood, herein describe first in-depth analysis neutrophil phenotypes these tissues. Orthogonal profiling strategies humans mice revealed that tumor-associated (TANs) differ significantly from blood have a prolonged lifespan immune-suppressive pro-angiogenic capacity. TANs exhibit distinct inflammatory signature, driven by combination soluble mediators necrosis factor alpha (TNF-ɑ) Ceruloplasmin, which is more pronounced versus glioma. Myeloid cells, macrophages, emerge at core this network pro-inflammatory mediators, supporting concept critical myeloid niche regulating overall suppression human tumors.

Language: Английский

Citations

78
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms DOI Creative Commons
Leire Bejarano,

Annamaria Kauzlaric,

Eleni Lamprou

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(3), P. 378 - 395.e10

Published: Jan. 21, 2024

Brain metastasis (BrM) is a common malignancy, predominantly originating from lung, melanoma, and breast cancers. The vasculature key component of the BrM tumor microenvironment with critical roles in regulating metastatic seeding progression. However, heterogeneity major vascular components, namely endothelial mural cells, still poorly understood. We perform single-cell bulk RNA-sequencing sorted cell types detect multiple subtypes enriched specifically compared to non-tumor brain, including previously unrecognized immune regulatory subtypes. integrate human data mouse models, creating platform interrogate targets for treatment BrM. find that CD276 checkpoint molecule significantly upregulated vasculature, anti-CD276 blocking antibodies prolonged survival preclinical trials. This study provides important insights into complex interactions between cancer translational relevance designing therapeutic interventions.

Language: Английский

Citations

28
The temporal progression of lung immune remodeling during breast cancer metastasis DOI
Christopher S. McGinnis, Zhuang Miao, Daphne Superville

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(6), P. 1018 - 1031.e6

Published: May 30, 2024

Language: Английский

Citations

16