Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients DOI
Xavier Charmetant, Maxime Espi, Iliès Benotmane

et al.

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(636)

Published: Feb. 1, 2022

Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response vaccines. We observed that previous infection with severe acute respiratory syndrome 2 (SARS-CoV-2), but not the standard two-dose regimen of vaccination, provided protection against symptomatic COVID-19 in kidney transplant recipients. therefore compared cellular humoral immune responses these two groups patients. Neutralizing anti-receptor-binding domain (RBD) immunoglobulin G (IgG) antibodies were identified as primary correlate for Analysis virus-specific B T cell suggested generation neutralizing anti-RBD IgG may have depended on cognate T-B interactions took place germinal center, potentially acting a limiting checkpoint. High-dose mycophenolate mofetil, an immunosuppressive drug, was associated fewer antigen-specific follicular helper (TFH) cells after vaccination; this patients recently infected SARS-CoV-2. Last, we that, independent prospective cohorts, administration third dose SARS-CoV-2 mRNA vaccine restored titers about 40% individuals had previously responded doses vaccine. Together, findings suggest improves RBD-specific treated drugs.

Language: Английский

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern DOI Creative Commons
Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis

et al.

Science, Journal Year: 2021, Volume and Issue: 374(6572)

Published: Oct. 15, 2021

Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection compared with people recovered from SARS-CoV-2. Humoral cellular was observed vaccinated individuals, as were functional Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) variants. Analysis cell activity suggested that robust may prevent hospitalization by limiting development disease. —PNK

Language: Английский

Citations

807
Humoral and cellular immune memory to four COVID-19 vaccines DOI Creative Commons
Zeli Zhang, José Mateus, Camila H. Coelho

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(14), P. 2434 - 2451.e17

Published: May 27, 2022

Language: Английский

Citations

468
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses DOI Creative Commons
Mohamad‐Gabriel Alameh, István Tombácz, Emily Bettini

et al.

Immunity, Journal Year: 2021, Volume and Issue: 54(12), P. 2877 - 2892.e7

Published: Nov. 4, 2021

Language: Английский

Citations

464
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination DOI Creative Commons
Katharina Röltgen, Sandra C. A. Nielsen, Oscar Silva

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(6), P. 1025 - 1040.e14

Published: Jan. 25, 2022

During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated infection or adenoviral (ChAdOx1-S Gam-COVID-Vac) inactivated viral (BBIBP-CorV) vaccines. analyzed human lymph nodes after for correlates of serological differences. Antibody breadth against variants is lower compared with all vaccines evaluated but improves over several months. Viral variant elicits variant-specific antibodies, prior imprints responses toward Wuhan-Hu-1 rather than antigens. In contrast to disrupted germinal centers (GCs) in during infection, stimulates robust GCs containing spike antigen up 8 weeks postvaccination some cases. antibody specificity, breadth, maturation are affected imprinting exposure history distinct histological antigenic contexts vaccination.

Language: Английский

Citations

383
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease DOI
David Goldblatt, Galit Alter, Shane Crotty

et al.

Immunological Reviews, Journal Year: 2022, Volume and Issue: 310(1), P. 6 - 26

Published: June 5, 2022

Antibodies against epitopes in S1 give the most accurate CoP infection by SARS-CoV-2 coronavirus. Measurement of those antibodies neutralization or binding assays both have predictive value, with antibody titers giving highest statistical correlation. However, protective functions are multiple. multiple other than influence efficacy. The role cellular responses can be discerned respect to CD4

Language: Английский

Citations

244
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes DOI
Claudia P. Arevalo, Marcus J. Bolton, Valerie Le Sage

et al.

Science, Journal Year: 2022, Volume and Issue: 378(6622), P. 899 - 904

Published: Nov. 24, 2022

Seasonal influenza vaccines offer little protection against pandemic virus strains. It is difficult to create effective prepandemic because it uncertain which subtype will cause the next pandemic. In this work, we developed a nucleoside-modified messenger RNA (mRNA)-lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known A subtypes and B lineages. This multivalent elicited high levels of cross-reactive subtype-specific antibodies in mice ferrets that reacted encoded antigens. Vaccination protected challenged with matched mismatched viral strains, was at least partially dependent on antibodies. Our studies indicate mRNA can provide antigenically variable viruses by simultaneously inducing multiple

Language: Английский

Citations

225
Immunological memory to SARS‐CoV ‐2 infection and COVID ‐19 vaccines DOI Creative Commons
Alessandro Sette, Shane Crotty

Immunological Reviews, Journal Year: 2022, Volume and Issue: 310(1), P. 27 - 46

Published: June 22, 2022

Immunological memory is the basis of protective immunity provided by vaccines and previous infections. can develop from multiple branches adaptive immune system, including CD4 T cells, CD8 B long-lasting antibody responses. Extraordinary progress has been made in understanding to SARS-CoV-2 infection COVID-19 vaccines, addressing development; quantitative qualitative features different cellular anatomical compartments; durability each component antibodies. Given sophistication measurements; size human studies; use longitudinal samples cross-sectional head-to-head comparisons between or for 1 year already supersedes that any other acute infectious disease. This knowledge may help inform public policies regarding as well scientific development future against diseases.

Language: Английский

Citations

218
Long-primed germinal centres with enduring affinity maturation and clonal migration DOI Open Access
Jeong Hyun Lee, Henry J. Sutton, Christopher A. Cottrell

et al.

Nature, Journal Year: 2022, Volume and Issue: 609(7929), P. 998 - 1004

Published: Sept. 21, 2022

Language: Английский

Citations

127
T Cell Responses to SARS-CoV-2 DOI
Alessandro Sette, John Sidney, Shane Crotty

et al.

Annual Review of Immunology, Journal Year: 2023, Volume and Issue: 41(1), P. 343 - 373

Published: Feb. 8, 2023

A large body of evidence generated in the last two and a half years addresses roles T cells SARS-CoV-2 infection following vaccination. Infection or vaccination induces multi-epitope CD4 CD8 cell responses with polyfunctionality. Early have been associated mild COVID-19 outcomes. In concert animal model data, these results suggest that while antibody are key to prevent infection, may also play valuable reducing disease severity controlling infection. memory after is sustained for at least six months. While neutralizing impacted by variants, most preserved. This review highlights extensive progress made, data knowledge gaps remain, our understanding vaccines.

Language: Английский

Citations

126
Antibody-mediated neutralization of SARS-CoV-2 DOI Creative Commons

Henning Gruell,

Kanika Vanshylla, Timm Weber

et al.

Immunity, Journal Year: 2022, Volume and Issue: 55(6), P. 925 - 944

Published: May 13, 2022

Language: Английский

Citations

120