Cortical Network and Projection Neuron Types that Articulate Serial Order in a Skilled Motor Behavior DOI
Yi Li, Xu An, Yongjun Qian

et al.

Published: Jan. 1, 2023

Skilled motor behaviors require orderly coordination of multiple constituent movements with sensory cues towards achieving a goal, but the underlying brain circuit mechanisms remain unclear. Here we show that target-guided reach-grasp-to-drink (RGD) in mice involves ordering and set forelimb oral actions. Cortex-wide activity imaging glutamatergic projection neuron (PN) types uncovered network, involving secondary cortex (MOs), primary somatosensory cortex, tracked RGD movements. Photo-inhibition highlighted MOs coordinating Within MOs, population neural trajectories progression single activities integrated across Notably, intratelencephalic, pyramidal tract, corticothalamic PN correlated action coordination, showed distinct dynamics trajectories, differentially contributed to movement coordination. Our results delineate cortical network key areas, types, therein articulate serial order skilled behavior.

Language: Английский

Re-examining the pathobiological basis of gait dysfunction in Parkinson’s disease DOI
Newton Cho, Lorraine V. Kalia, Suneil K. Kalia

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Integrating across behaviors and timescales to understand the neural control of movement DOI Creative Commons
Jimmie M. Gmaz, Jason Keller, Joshua T. Dudman

et al.

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 85, P. 102843 - 102843

Published: Feb. 13, 2024

The nervous system evolved to enable navigation throughout the environment in pursuit of resources. Evolutionarily newer structures allowed increasingly complex adaptations but necessarily added redundancy. A dominant view movement neuroscientists is that there a one-to-one mapping between brain region and function. However, recent experimental data hard reconcile with most conservative interpretation this framework, suggesting degree functional redundancy during performance well-learned, constrained behaviors. This apparent likely stems from bidirectional interactions various cortical subcortical involved motor control. We posit these connections flexible across change depending upon behavioral demands, such as acquisition, execution or adaptation skill. Observing both multiple actions timescales can help isolate contributions individual structures, leading an integrated understanding neural control movement.

Language: Английский

Citations

7
Corticostriatal pathways for bilateral sensorimotor functions DOI Creative Commons
Ruy Gómez-Ocádiz, Gilad Silberberg

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 83, P. 102781 - 102781

Published: Sept. 9, 2023

Corticostriatal pathways are essential for a multitude of motor, sensory, cognitive, and affective functions. They mediated by cortical pyramidal neurons, roughly divided into two projection classes: the tract (PT) intratelencephalic (IT). These have been focus numerous studies in recent years, revealing their distinct structural functional properties. Notably, synaptic connectivity within ipsi- contralateral striatal microcircuits is characterized high degree target selectivity, providing means to regulate local neuromodulatory landscape striatum. Here, we discuss findings regarding organization PT IT corticostriatal its implications bilateral sensorimotor

Language: Английский

Citations

12
Distinct anatomical and functional corticospinal inputs innervate different spinal neuron types DOI Creative Commons

Samaher Fageiry,

Claire L. Warriner, Jackson Loper

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

SUMMARY The corticospinal tract exerts its influence on movement through spinal neurons, which can be divided into types that exhibit distinct functions. However, it remains unknown whether these functional distinctions are reflected in the inputs different of neurons receive. Using rabies monosynaptic tracing from individual neuron cervical cord and 3D histological reconstruction mice, we discovered receive distinctly distributed across cortex, aligned with cell type function. This included a distinct, sparse distribution direct cortex onto motor neurons. Coupling activity measurement during behavior revealed interneuron input patterns, primarily due to topographical contacting them. Our results establish get anatomical reveal functionally relevant homology primate organization.

Language: Английский

Citations

4
Cell-class-specific orofacial motor maps in mouse neocortex DOI Creative Commons
Keita Tamura, Pol Bech, Hidenobu Mizuno

et al.

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Cortical motor maps represent fundamental organizing principles for voluntary control,1 yet their underlying structure remains poorly understood, including regions of sensory2,3 and parietal cortex,4 as well the classical frontal cortex. To understand how anatomically distinct cortical areas are organized into functional units controlling movements, here, we refined by selectively stimulating genetically defined subpopulations excitatory neurons. Surprisingly, found spatially segregated modules in orofacial optogenetically different classes The overall map jaw opening revealed all neurons spanned anterior lateral cortex broadly. By contrast, jaw-opening specific cell were focalized either primary motor, secondary or somatosensory within neurons, demonstrating cell-class-specific modules. Simultaneous wide-field calcium imaging activity propagation from optically stimulated to area correlating with movement vigor. largely stable across lick learning important exceptions indicating expansion other module zones. Our data suggest that interacting sensorimotor cortices might contribute movement.

Language: Английский

Citations

0
Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping DOI Open Access
Harrison A. Grier,

Sohrab Salimian,

Matthew T. Kaufman

et al.

Published: April 22, 2025

Coordinated forelimb actions, such as reaching and grasping, rely on motor commands that span a spectrum from abstract target specification to detailed instantaneous muscle control. The sensorimotor cortex is central controlling these complex movements, yet how the command signals are distributed across its numerous subregions remains unclear. In particular, in mice it unknown if primary (M1) somatosensory (S1) cortices represent low-level joint angle details addition high-level like movement direction. Here, we combine high quality markerless tracking two-photon imaging during reach-to-grasp task quantify movement-related activity mouse caudal area (CFA) S1 (fS1). Linear decoding models reveal strong representation of proximal distal angles both areas, areas support with comparable fidelity. Despite shared encoding, time course target-specific information varied areas. CFA exhibited early onset sustained encoding while fS1 was more transiently modulated around lift onset. These results unique contributions implicating cortical circuit for control than has been previously considered.

Language: Английский

Citations

0
Motor cortex directly excites the output nucleus of the basal ganglia, the substantia nigra pars reticulata. DOI Creative Commons

William Scott Thompson,

Sten Grillner, Gilad Silberberg

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 20, 2024

Abstract Inhibitory neurons of the substantia nigra pars reticulata (SNr) serve as a primary output through which basal ganglia regulate behaviour. Projections to SNr from beyond have also been identified anatomically. Using virally-targeted optogenetic approach, combined with whole cell patch-clamp recordings in acute brain slices, we show that projection and secondary motor cortices (M1 M2) make functional excitatory synapses subpopulations inhibitory neurons. Furthermore, demonstrate photostimulation these cortical axon terminals increases neuron firing rate. To further investigate spatial organisation input SNr, employed transsynaptic viral-labelling approach identify receiving monosynaptic M1 M2. We found topographical relationship between cortex downstream targets cortical-recipient subpopulations. These findings reveal pathways by M2 can directly modulate different targets.

Language: Английский

Citations

3
Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task DOI
Tejapratap Bollu, Samuel C. Whitehead,

Nikil Prasad

et al.

Journal of Neurophysiology, Journal Year: 2024, Volume and Issue: 132(3), P. 829 - 848

Published: July 31, 2024

To test the role of different cortical areas in holding still and reaching to targets, this study combined home-cage training with optogenetic silencing as mice engaged a learned center-out-reach task. Inactivation specifically contralateral caudal forelimb area (CFA) impaired corrective movements necessary reach spatial targets earn reward.

Language: Английский

Citations

3
Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat DOI Creative Commons
Celia Garau, Jessica Hayes, Giulia Chiacchierini

et al.

Current Biology, Journal Year: 2023, Volume and Issue: 33(22), P. 4786 - 4797.e4

Published: Oct. 9, 2023

Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is regarding functionality A13-DA circuits. Using TH-specific loss-of-function methodology techniques monitor population activity in transgenic rats vivo, we investigated contribution reward movement-related actions. Our work demonstrates a role for grasping handling objects but not reward. responded strongly when animals grab manipulate food items, whereas inactivation or degeneration prevented from successfully doing so—a deficit partially attributed reduction grip strength. By contrast, there was no relation between food-seeking behavior were tested on reward-based task did include reaching/grasping response. Motivation unaffected, goal-directed items general intact following neuronal inactivation/degeneration. An anatomical investigation confirmed project superior colliculus (SC) also demonstrated novel projection reticular formation (RF). These results establish functional prehensile actions uncoupled motivational factors contribute initiation forelimb movements help position circuits into framework centrally located DA populations ability coordinate movement.

Language: Английский

Citations

7
Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder DOI Creative Commons
Daniel Dautan, Wojciech Pasławski,

Sergio Montejo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 26, 2024

Parkinson's disease (PD) is characterized by progressive motor as well less recognized non-motor symptoms that arise often years before manifestation, including sleep and gastrointestinal disturbances. Despite the heavy burden on patient's quality of life, these manifestations are poorly understood. To elucidate temporal dynamics disease, we employed a mouse model involving injection alpha-synuclein (αSyn) pre-formed fibrils (PFF) in duodenum antrum gut-brain Parkinsonism. Using anatomical mapping αSyn-PFF propagation behavioral physiological characterizations, unveil correlation between post-injection time αSyn non-motor/motor disease. We highlight concurrent presence aggregates key brain regions, expressing acetylcholine or dopamine, involved duration, wakefulness, particularly REM-associated atonia corresponding to REM disorder-like symptoms. This study presents novel in-depth exploration into multifaceted nature PD, unraveling complex connections α-synucleinopathies, connectivity, emergence phenotypes.

Language: Английский

Citations

2