Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106755 - 106755
Published: Nov. 1, 2024
Language: Английский
Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(11), P. 1329 - 1339
Published: Aug. 5, 2024
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting millions of people and rapidly increasing over last decades. Even though there no intervention yet to stop pathology, many efficient treatment methods are available, including for patients with advanced PD. Neuroplasticity a fundamental property human brain adapt both external changes internal insults pathological processes. In this paper we examine current knowledge concepts concerning at network level, cellular level molecular as parts neuroplastic response protein aggregation synapse loss neuronal in We analyse beneficial, compensatory effects, such augmentation nigral neurons efficacy, well negative, maladaptive levodopa-induced dyskinesia. Effects physical activity different treatments on neuroplasticity considered opportunity biomarkers identification use discussed.
Language: Английский
Citations
8
Neuroscience, Journal Year: 2024, Volume and Issue: 546, P. 20 - 32
Published: March 21, 2024
Evidence suggests that dopamine activity provides a US-related prediction error for Pavlovian conditioning and the reinforcement signal supporting acquisition of habits. However, its role in goal-directed action is less clear. There are currently few studies have assessed release as animals acquire perform self-paced instrumental actions. Here we briefly review literature documenting psychological, behavioral neural bases actions rats mice, before turning to describe recent investigating learning performance. Plasticity dorsomedial striatum, central node network action, clearly requires release, timing which, relative cortical thalamic inputs, determines degree form plasticity. Beyond this, bilateral appears reflect reward errors experience consequences an action. Such signals feedforward update value specific associated with outcome during subsequent performance, at time reflecting updated predicted value. More recently, evidence has also emerged hemispherically lateralised action; greater hemisphere contralateral spatial target This effect emerges over course strength action-outcome association. Thus, their association shape performance processes necessary support this control.
Language: Английский
Citations
5
Published: Jan. 1, 2025
Background: Lesions in the basal ganglia (BG) are associated with more severe epileptic seizures and complications temporal lobe epilepsy (TLE). However, atrophy heterogeneity of BG has not been fully explored.Methods: Here, we analyzed MRI data from 89 patients TLE 36 control subjects. Based on gray matter volume BG, performed clustering validation using machine learning (ML), including consensus principal component analysis. Subsequently, identified characteristics alterations brain functional activity across different clusters. Finally, employed supervised ML algorithms to develop predictive models aimed at guiding clinical practice.Findings: Within cohort, two distinct clusters, designated as TLE-C1 TLE-C2. In TLE-C1, observed extensive significant cognitive impairment. When atrophied nuclei seed, demonstrated significantly enhanced resting-state connectivity, predominantly memory/emotion-related regions dominant hemisphere. addition, by integrating structural data, developed four binary classification prediction models, achieving AUCs 0.944, 0.880, 0.966, 0.920, respectively.Interpretation: Our results present a novel ML-based imaging approach, which stratifies inter-individual variability into categories. This provides critical dimensional evidence for further investigation neural mechanisms TLE.Funding: work was supported grant National Natural Science Foundation China (NO.81560223, NO.82460269).Declaration Interest: The authors declare no competing interests.Ethical Approval: All participants this study were informed protocol provided consent, reviewed approved Ethics Committee First Affiliated Hospital Guangxi Medical University.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 26, 2025
Purpose: To investigate whether altered functional activity, connectivity (FC), and structural (SC) following acute carbon monoxide (CO) poisoning contribute to delayed neurological sequelae (DNS) occurrence. Methods: Binary degree centrality (DC) seed-based FC were investigated in 18 patients with DNS, 26 without 30 healthy controls. Duration of CO exposure coma severity indices-related fibers was detected by connectometry analysis the identified fiber tracts tracked their SC alteration quantify fractional anisotropy (FA). Results: Acute induced DC change prefrontal cortex (PFC), visual cortex, primary sensory anterior cerebellum, between right fusiform gyrus (seed) bilateral PFC left inferior occipital (Gaussian random field corrected, P < 0.05). Poisoning WM consisted corpus callosum some association projection (false discovery rate Only postcentral reduced could identify DNS occurrence (P Conclusions: The abnormalities visual- sensory- subsequent represent one potential neural mechanisms underlying DNS.
Language: Английский
Citations
0
Movement Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response FoG treatment poorly understood. Prior vesicular acetylcholine transporter positron emission tomography (VAChT PET) imaging studies implicate degeneration cholinergic pathways, including bilateral striatal and limbic archicortex deficits, as significant contributors FoG. We aim investigate whether specific system changes are associated responsiveness levodopa in PD patients. Thirty six subjects (31M/5F) completed [18F]-fluoroethoxybenzovesamicol ([18F]FEOBV) underwent videotaped clinical assessments for on off levodopa. Sixteen had l-dopa-unresponsive Whole brain voxel-based analyses [18F]FEOBV PET (false discovery rate-corrected at P < 0.05 adjusted levodopa-equivalent dose) showed those more severe terminal deficits insula, hippocampi, fimbria, lateral geniculate nuclei; left mid-temporal, putamen, posterior cingulate regions; right mid-frontal region anterior ventral nucleus thalamus compared l-dopa-responsive unresponsive reductions, mostly extra-striatal regions involved multisensory cognitive integration postural control well spatial navigation. lack involvement points disruption widespread cerebral network functions may explain treatment-resistant nature © 2025 Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.
Language: Английский
Citations
0
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106918 - 106918
Published: April 1, 2025
Language: Английский
Citations
0
Elmi əsərlər., Journal Year: 2024, Volume and Issue: 91(1), P. 230 - 235
Published: June 3, 2024
The article talks about inhibitory control, which is one of the executive functions in children with ADHD. These always have impaired functions. However, dysfunction does not mean Evaluation can help diagnose this neurodevelopmental disorder. One most common function deficits associated ADHD problems control. They find it difficult to control inappropriate or impulsive behavior, external interference, and therefore trouble concentrating. Inhibition plays an important role successful requiring suppression extraneous interference focus attention, ignoring irrelevant cues recall stored information, habitual responses adaptive decision making. Impaired response inhibition directly affects four functions: working memory, self-regulation, language internalization, restructuring. This, turn, leads difficulties complex movements goal-directed especially those related motor verbal fluency, syntax. Given influence on ADHD, author argues that training enhances may improve symptoms. A number studies area demonstrated effectiveness trainings designed enhance
Language: Английский
Citations
0
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Sept. 25, 2024
Voxel-mirrored homotopic connectivity (VMHC) is utilized to assess the functional of neural networks by quantifying similarity between corresponding regions in bilateral hemispheres brain. The exploration VMHC abnormalities basal ganglia ischemic stroke (BGIS) patients across different cerebral has been limited. This study seeks establish a foundation for understanding status both brain BGIS through utilization analysis utilizing resting-state magnetic resonance imaging (rs-fMRI).
Language: Английский
Citations
0
European Journal of Neurology, Journal Year: 2024, Volume and Issue: 32(1)
Published: Dec. 2, 2024
Abstract Background and Purpose To date, no previous studies have used multishell diffusion MRI to identify striatal microstructural damage in vivo amyotrophic lateral sclerosis (ALS) patients. Thus, the present study, we aimed comprehensively explore connectivity‐based selective subregion sporadic ALS patients its associations with motor disability, cognitive deficits, serum biomarkers. Methods In this retrospective 79 53 healthy controls (HCs) who underwent clinical assessment, neurofilament light (NfL) measurement, genetic testing, scanning were included. Using a probabilistic tractography approach, striatum was segmented into six subregions based on their corticostriatal connectivity. Three neurite orientation dispersion density imaging (NODDI) parameters, index (NDI), (ODI), isotropic volume fraction (ISO), of measured. Results Compared HCs, had significantly lower NDI bilateral right frontal subregions, ODI higher ISO after familywise error ( p < 0.05). Moreover, correlated disabilities, NfL levels = 0.020–0.002). Conclusions Our study provides clear evidence demonstrating that is definite feature suggesting may play an important role disability deficits
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 1, 2024
Abstract The 6-OHDA mouse model recapitulates midbrain dopaminergic cell loss and associated motor deficits akin to those observed in Parkinson’s disease. Emerging evidence suggests that modulating interneurons the primary cortex could offer a means mitigate symptoms. In cortex, perineuronal nets (PNNs), specialized extracellular matrix structure generally present around fast-spiking parvalbumin interneurons, can modulate neural activity circuit plasticity. We found removing PNNs through unilateral or bilateral ChABC injection temporarily altered behavior. Surprisingly, reduced are two weeks after lesions, whereas five lesion, return control levels. Subsequent injections significantly improved function animals only when with stimulation involving enriched housing daily training. Thus, PNN modulation of disease enables local circuits adapt inputs, resulting
Language: Английский
Citations
0