Artificial Light at Night and Type 2 Diabetes Mellitus DOI Creative Commons
Jong Ha Baek, Yong Zhu, Chandra L. Jackson

et al.

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(5), P. 847 - 863

Published: Sept. 13, 2024

The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor natural circadian rhythms, potentially leading to rise unhealthy lifestyle-related behaviors (e.g., poor sleep; shift work). This phenomenon been associated with an increased risk type 2 diabetes mellitus (T2DM), which is pressing global public health concern. However, date, reviews summarizing associations between ALAN T2DM have primarily focused on the limited characteristics exposure intensity) ALAN. literature review extends beyond prior by consolidating recent studies from 2000 2024 regarding both indoor outdoor incidence or prevalence T2DM. We also described potential biological mechanisms through modulates glucose metabolism. Furthermore, we outlined knowledge gaps investigated how various only intensity (including type, timing, duration, wavelength, individual sensitivity) influence risk. Recognizing detrimental impact sleep behavioral correlates physical activity dietary patterns, additionally summarized investigating mediating role each component relationship Lastly, proposed implications chronotherapies chrononutrition for management context exposure.

Language: Английский

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration DOI
Han Chen, Chao Liu, Shiyao Cui

et al.

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

5
Association between exposure to outdoor artificial light at night during pregnancy and glucose homeostasis: A prospective cohort study DOI
Lei Zhang, Haixia Wang,

Ping Zu

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 247, P. 118178 - 118178

Published: Jan. 13, 2024

Language: Английский

Citations

4
Artificial-Cofactor-Mediated Hydrogen and Electron Transfer Endows AuFe/Polydopamine Superparticles with Enhanced Glucose Oxidase-Like Activity DOI

Yinjun Tang,

Xupeng Liu,

Pengcheng Qi

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(32), P. 9974 - 9982

Published: July 31, 2024

Various applications related to glucose catalysis have led the development of functional nanozymes with oxidase (GOX)-like activity. However, unsatisfactory catalytic activity is a major challenge for their practical due inefficient hydrogen and electron transfer. Herein, we present synthesis AuFe/polydopamine (PDA) superparticles that exhibit photothermal-enhanced GOX-like Experimental investigations theoretical calculations reveal oxidation process catalyzed by AuFe/PDA follows an artificial-cofactor-mediated atom transfer mechanism, which facilitates generation carbon-centered radical intermediates. Rather than depending on charged Au surfaces thermodynamically unstable hydride transfer, Fe(III)-coordinated PDA abundant amino phenolic hydroxyl groups serves as cofactor mimics, facilitating both in process. Finally, leveraging catalase-like activities AuFe/PDA, establish highly sensitive accurate point-of-care testing blood determination exceptional anti-jamming capabilities.

Language: Английский

Citations

4
A Visual Circuit Linked To The Lateral Hypothalamus Mediates The Food Consumption-Suppressing And Weight Gain-Attenuating Effects Of Bright Light Treatment DOI Creative Commons
Lu Huang, Wen Li, Xiaodan Huang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract In addition to its well-established role in vision, environmental light also plays a crucial non-image-forming visual functions, including the regulation of instinctive behaviors such as feeding. Clinical evidence suggests that bright therapy can alleviate symptoms individuals with obesity. However, neural mechanisms underlying influence on feeding remain poorly understood. this study, we demonstrate treatment effectively reduces food intake and mitigates weight gain mice through circuit involving lateral hypothalamic area (LHA). Specifically, subset SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate GABAergic neurons ventral geniculate nucleus (vLGN), which turn inhibits LHA. Activation both vLGN-projecting RGCs vLGN-to-LHA pathway is sufficient suppress consumption attenuate gain. Importantly, provide direct suppressive effects rely activation retina-vLGN-LHA pathway. Together, our results delineate an LHA-related consumption-suppressing gain-attenuating treatment.

Language: Английский

Citations

0
Physiological rhythms and metabolic regulation: Shining light on skeletal muscle DOI Creative Commons
James A. Betts, Kelly A. Bowden Davies, Harry Smith

et al.

Experimental Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Metabolic regulation is essential for maintaining homeostasis in response to fluctuating dietary nutrient availability. In this review, we explore how metabolic health can be affected by the temporal alignment between daily behavioural patterns (e.g., eating, physical activity and sleep) recurring cycles underlying physiology ‘circadian’ rhythms). Misalignment within and/or these lead dysregulation, increasing risk of chronic disease states such as obesity, type 2 diabetes cardiovascular disease. Conversely, improved strategically aligning certain with endogenous rhythms physiology. Dietary interventions based upon reasoning are referred chrono‐nutrition strategies. Skeletal muscle an important tissue relation both whole‐body metabolism behaviour plays a central role physiological respond timing delivery/availability. Few studies have examined human skeletal muscle, providing opportunities advance current understanding affects metabolism.

Language: Английский

Citations

0
Hypothalamic GABAergic neurons: their roles in health and metabolic diseases DOI Creative Commons
Bingwei Wang, Yang Yu, Juan Li

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Hypothalamic GABAergic neurons are important in regulating metabolic homeostasis and energy balance. Serving as critical integrators of catabolic anabolic processes, these orchestrate a broad spectrum functions, including feeding, nutrient metabolism, fluid homeostasis, basal thermoregulation, circadian rhythms. Recent advances neuroscience have facilitated deeper exploration the role hypothalamic regulation. Emerging research has uncovered key mechanisms through which modulate balance maintain These findings not only enhance our understanding obesity related disorders but also underscore link between dysfunction prevalent diseases such type 2 diabetes. This review summarizes latest advancements It aims to elucidate neural molecular underlying control offering new perspectives for diagnosis treatment disorders.

Language: Английский

Citations

0
Research on Indoor Health Lighting Design Based on Silicon Substrate Golden Light LED Technology DOI Creative Commons

Zhuoyi Jiang,

Yeqing Zhu, Yihan Wang

et al.

Buildings, Journal Year: 2025, Volume and Issue: 15(6), P. 932 - 932

Published: March 15, 2025

Silicon substrate golden light LED, as an emerging blue-light-free health lighting technology, has become one of the key technologies for home environments. This study uses silicon LED source lighting, and based on demands two indoor types, employs DIALux Evo simulation software to simulate environment. First, simulated data various areas are compared with national standards (GB/T50034-2024) verify whether type meets requirements. Next, a comparison is made between efficiency reference sample validate possesses high low power consumption. Finally, long-term exposure both used record secretion levels melatonin in human body. The experimental results show that not only provides sufficient but also demonstrates Additionally, under illumination concentration significantly increases (960 ± 15) pg/mL after 2.5 h exposure, which 8.2 times higher than conventional group (t = 12.34, df 14, p < 0.001). technology feasible solution design by creating zero-blue-light

Language: Английский

Citations

0
Targeting the central and peripheral nervous system to regulate bone homeostasis: mechanisms and potential therapies DOI Creative Commons
Tongzhou Liang, Zheyu Jin, Yuejun Lin

et al.

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 20, 2025

Abstract The skeleton is innervated by different types of nerves and receives signaling from the nervous system to maintain homeostasis facilitate regeneration or repair. Although role peripheral signals in regulating bone has been extensively investigated, intimate relationship between central remains less understood, yet it emerged as a hot topic field. In this review, we discussed clinical observations animal studies that elucidate connection metabolism, either intact after injury. First, explored mechanistic linking specific brain nuclei with homeostasis, including ventromedial hypothalamus, arcuate nucleus, paraventricular hypothalamic amygdala, locus coeruleus. We then focused on characteristics innervation nerve subtypes, such sensory, sympathetic, parasympathetic nerves. Moreover, summarized molecular features regulatory functions these Finally, included available translational approaches utilize function improve promote regeneration. Therefore, considering within context neuromusculoskeletal interactions can deepen our understanding skeletal repair process, ultimately benefiting future translation.

Language: Английский

Citations

0
Novel insights into athlete physical recovery concerning lactate metabolism, lactate clearance and fatigue monitoring: A comprehensive review DOI Creative Commons
Tao Huang, Z. Li, Ke Wang

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 25, 2025

Lactate accumulation will appear in athlete skeletal muscle after intense exercise. If the high lactate level maintains, athletes sustain fatigue and athletic capacity decline due to internal environment normal metabolism disruption. In order enhance physical recovery exercise performance high-intensity sport events, it is of great significance explore scientific intervention procedures based on quicker clearance blood This article collects classic novel literature terms metabolism, monitoring during by searching PubMed database then summarizes comprehensive insights into with corresponding figures charts. We introduce generation transformation process lactate, pathways methods for detail. The involve biochemical (oxygen inhalation, amino acids supplement, targeting free radical, alkaline reserve, vasomotion, ribose supplement), activities (exercise-mediated activities, non-exercise activities) training (interval training, altitude training) accelerate metabolism. factors blood, urine, sweat, saliva exhaled gas. hope this review can offer some significant assistance recovering improving achievements clearance.

Language: Английский

Citations

0
Increased oxytocin/vasopressin ratio in bipolar disorder in a cohort of human postmortem adults DOI Creative Commons
Hong Tan, Yu‐Ting Hu,

A N Goudswaard

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106904 - 106904

Published: April 1, 2025

Bipolar disorder (BD) and major depressive (MDD) share some common characteristics in stress-related brain circuits, but they also exhibit distinct symptoms. Our previous postmortem research on the immunoreactivity (ir) levels of neuropeptide oxytocin (OT) hypothalamic paraventricular nucleus (OTPVN) clinical plasma OT suggested that increased is a potential trait marker for BD. However, dysregulation related arginine vasopressin (AVP), often shows opposite effects stress responses compared to has not been investigated Moreover, it remains so far unknown what contribution may be produced supraoptic (SON), another source (OTSON). Therefore, present study, alterations OT-ir first time AVP-ir were determined SON PVN among patients with BD, MDD, matched controls. We observed significantly OTPVN-ir relatively stable AVPPVN-ir male decreased female BD patients. A ratio OT-ir/AVP-ir was only both, SON. No significant changes or found MDD data illustrate clear disease- sex-specificity AVP In addition, since lithium nephropathy, have direct effect symptoms

Language: Английский

Citations

0