Artificial Light at Night and Type 2 Diabetes Mellitus DOI Creative Commons
Jong Ha Baek, Yong Zhu, Chandra L. Jackson

et al.

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(5), P. 847 - 863

Published: Sept. 13, 2024

The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor natural circadian rhythms, potentially leading to rise unhealthy lifestyle-related behaviors (e.g., poor sleep; shift work). This phenomenon been associated with an increased risk type 2 diabetes mellitus (T2DM), which is pressing global public health concern. However, date, reviews summarizing associations between ALAN T2DM have primarily focused on the limited characteristics exposure intensity) ALAN. literature review extends beyond prior by consolidating recent studies from 2000 2024 regarding both indoor outdoor incidence or prevalence T2DM. We also described potential biological mechanisms through modulates glucose metabolism. Furthermore, we outlined knowledge gaps investigated how various only intensity (including type, timing, duration, wavelength, individual sensitivity) influence risk. Recognizing detrimental impact sleep behavioral correlates physical activity dietary patterns, additionally summarized investigating mediating role each component relationship Lastly, proposed implications chronotherapies chrononutrition for management context exposure.

Language: Английский

Photoperiod influences visceral adiposity and the adipose molecular clock independent of temperature in wild‐derived Peromyscus leucopus DOI Creative Commons

Margaret E. Newport,

Paul J. Wilson, Shanna Lowes

et al.

FASEB BioAdvances, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Physiology is closely synchronized to daily and seasonal light/dark cycles. Humans artificially extend daylight experience irregular light schedules, resulting in dysregulation of metabolism body mass. In rodents, winter‐like conditions (cold short photoperiod) can alter energy balance adipose tissue To determine if photoperiod alone, independent temperature, a strong enough signal regulate adiposity, we compared the effects long at thermoneutrality on adiposity WAT gene expression photoperiod‐sensitive, F1 generation wild‐derived adult male white‐footed mice ( Peromyscus leucopus ). Mice were housed long‐day (16:8 light:dark) or short‐day (8:16 (27°C) for 4 weeks with extended being provided through artificial lighting. Photoperiod did not impact weight calorie consumption. However, selectively developed greater visceral mass without changing subcutaneous interscapular BAT This was accompanied by decrease Adrβ3 Ucp1 mRNA no change Pgc1a , Lpl Hsl . Expression Per1 Per2 Nr1d1 differed between photoperiods over time when aligned circadian but onset darkness, indicating alterations clock photoperiod. These findings suggest that promote fat accumulation supporting may play role obesity.

Language: Английский

Citations

0
Personal 24-hour light exposure pattern with obesity and adiposity-related parameters in school-aged children: a cross-sectional study based on compositional data analysis DOI

Wenqin Ding,

Qi Li, Yi Zhou

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121422 - 121422

Published: March 1, 2025

Language: Английский

Citations

0
Corneal metabolic biomarkers for moderate and high myopia in human DOI
Wenjing Wu, Yanzheng Song,

Mingshen Sun

et al.

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 237, P. 109689 - 109689

Published: Oct. 21, 2023

Language: Английский

Citations

8
Mapping the Retina onto the Brain DOI Open Access
Daniel Kerschensteiner, Marla B. Feller

Cold Spring Harbor Perspectives in Biology, Journal Year: 2023, Volume and Issue: 16(2), P. a041512 - a041512

Published: Dec. 5, 2023

Daniel Kerschensteiner1,2,3 and Marla B. Feller4,5 1Department of Ophthalmology Visual Sciences 2Department Neuroscience 3Department Biomedical Engineering, Washington University School Medicine, St. Louis, Missouri 63110, USA 4Department Molecular Cell Biology 5Helen Wills Institute, California, Berkeley, California 94720, Correspondence: mfeller{at}berkeley.edu; kerschensteinerd{at}wustl.edu

Language: Английский

Citations

8
Artificial Light at Night and Type 2 Diabetes Mellitus DOI Creative Commons
Jong Ha Baek, Yong Zhu, Chandra L. Jackson

et al.

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(5), P. 847 - 863

Published: Sept. 13, 2024

The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor natural circadian rhythms, potentially leading to rise unhealthy lifestyle-related behaviors (e.g., poor sleep; shift work). This phenomenon been associated with an increased risk type 2 diabetes mellitus (T2DM), which is pressing global public health concern. However, date, reviews summarizing associations between ALAN T2DM have primarily focused on the limited characteristics exposure intensity) ALAN. literature review extends beyond prior by consolidating recent studies from 2000 2024 regarding both indoor outdoor incidence or prevalence T2DM. We also described potential biological mechanisms through modulates glucose metabolism. Furthermore, we outlined knowledge gaps investigated how various only intensity (including type, timing, duration, wavelength, individual sensitivity) influence risk. Recognizing detrimental impact sleep behavioral correlates physical activity dietary patterns, additionally summarized investigating mediating role each component relationship Lastly, proposed implications chronotherapies chrononutrition for management context exposure.

Language: Английский

Citations

3