Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth DOI

Keqiang Rao,

Xinchao Zhang, Yi Luo

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115441 - 115441

Published: March 18, 2025

Language: Английский

DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma DOI
Ying Cao, Ruolan Qian, Ruiqin Yao

et al.

Developmental Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis DOI Creative Commons
Yixuan Wang,

Houkun Zhou,

Ying Liu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

Language: Английский

Citations

1
ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production DOI Creative Commons
Cuimiao Zheng, Hao Tan, Gang Niu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Lactate derived from aerobic glycolysis is crucial for DNA damage repair and chemoresistance. Nevertheless, it frequently noted that cancer cells depend on glutaminolysis to replenish essential metabolites. Whether how might enhance lactate production facilitate in remains unknown. Here, shown malate enzyme 2 (ME2), which metabolizes glutamine-derived pyruvate, contributes chemotherapy resistance ovarian cancer. Mechanistically, reduces the expression of glucose transporters impairs uptake cells. The resultant decrease intracellular levels triggers acetylation ME2 at lysine 156 by ACAT1, turn potentiates activity facilitates glutamine. ME2-derived development acquired chemoresistance subjected prolonged chemotherapy, primarily facilitating lactylation proteins involved homologous recombination repair. Targeting ACAT1 inhibit effectively reduced both vitro vivo models. These findings underscore significance acetylated ME2-mediated glutamine chemoresistance, particularly under conditions within cell, thereby complementing Warburg effect offering new perspectives metabolic links resistance.

Language: Английский

Citations

1
Integrative Analysis of the Fermentation Mechanisms, Antioxidant Properties, and Potential Health Benefits of Mulberry Wine Using Multiple Bioinformatics Approaches DOI

Chaohong He,

Johane Johari Mkunga,

Dongsheng Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106185 - 106185

Published: Feb. 1, 2025

Language: Английский

Citations

1
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth DOI

Keqiang Rao,

Xinchao Zhang, Yi Luo

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115441 - 115441

Published: March 18, 2025

Language: Английский

Citations

1