PubMed,
Journal Year:
2024,
Volume and Issue:
41(2), P. 288 - 294
Published: April 25, 2024
Monitoring
of
bowel
sounds
is
an
important
method
to
assess
motility
during
sleep,
but
it
seriously
affected
by
snoring
noise.
In
this
paper,
the
complete
ensemble
empirical
mode
decomposition
with
adaptive
noise
(CEEMDAN)
was
applied
remove
from
sleep.
Specifically,
noisy
were
first
band-pass
filtered,
then
decomposed
CEEMDAN
method,
and
finally
appropriate
components
selected
reconstruct
pure
sounds.
The
results
semi-simulated
real
data
showed
that
better
than
wavelet
denoising
method.
used
which
lays
foundation
for
using
intestinal
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 2, 2024
Abstract
Sleep
latency,
the
amount
of
time
that
it
takes
an
individual
to
fall
asleep,
is
a
key
indicator
sleep
need.
latency
varies
considerably
both
among
and
within
species
heritable,
but
lacks
comprehensive
description
its
underlying
genetic
network.
Here
we
conduct
genome-wide
association
study
latency.
Using
previously
collected
activity
data
on
wild-derived
population
flies,
calculate
confirming
significant,
heritable
variation
for
this
complex
trait.
We
identify
520
polymorphisms
in
248
genes
contributing
variability
Tests
mutations
23
candidate
additional
putative
pan-neuronal
knockdown
9
them
implicated
CG44153
,
Piezo
Proc-R
Rbp6
Two
large-effect
were
further
confirmed
via
rescue.
This
work
greatly
enhances
our
understanding
factors
influence
Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
unknown, P. e1126232024 - e1126232024
Published: Jan. 24, 2024
Imaging
brain
learning
and
memory
circuit
kinase
signaling
is
a
monumental
challenge.
The
s
eparation
of
p
hases-based
ctivity
r
eporter
k
inase
(SPARK)
biosensors
allow
circuit-localized
studies
multiple
interactive
kinases
in
vivo
,
including
protein
A
(PKA)
extracellular
signal-regulated
(ERK)
signaling.
In
the
precisely-mapped
Drosophila
learning/memory
circuit,
we
find
PKA
ERK
differentially
enriched
distinct
Kenyon
cell
connectivity
nodes.
We
discover
that
potentiating
normal
activity
induces
signaling,
expanding
function
within
new
presynaptic
postsynaptic
domains.
Activity-induced
shows
extensive
overlap
with
previously
selective
nodes,
while
activity-induced
arises
targeted
synaptic
transmission
blockade
cells
elevates
induction
normally
high
baseline
suggesting
lateral
feedback
inhibition.
overexpression
pathway-linking
Meng-Po
(human
SBK1)
serine/threonine
to
improve
acquisition
consolidation
results
dramatically
heightened
separable
revealing
both
synchronized
untapped
potential.
Finally,
mechanically-induced
epileptic
seizure
model
(
easily
shocked
“bang-sensitive”
mutants)
has
strongly
elevated,
Both
sexes
were
used
all
experiments,
except
for
hemizygous
male-only
model.
Hyperexcitable,
learning-enhanced,
models
have
comparably
elevated
common
basis
use-dependent
induction.
conclude
modulation
locally
coordinated
spatial
dynamics
underlying
susceptibility
linked
Significance
Statement
Critical
act
circuits
enable
experience-dependent
plasticity.
This
work
images
elucidate
circuit-level
organization
relative
mapped
different
exhibit
domains,
which
reorganized
by
levels.
newest
kinase,
Meng-Po/SBK1,
co-regulates
Targeted
over-expression
Meng-Po/SBK1
improves
memory,
indicating
potential
may
enhance
capabilities
learn
remember.
Linked
similarly
increases
circuitry,
trade-off
benefit
instability.
mechanistically
connects
hyperexcitation
via
Cell Reports,
Journal Year:
2024,
Volume and Issue:
43(6), P. 114282 - 114282
Published: May 24, 2024
The
suppressive
effect
of
insulin
on
food
intake
has
been
documented
for
decades.
However,
whether
signals
can
encode
a
certain
type
nutrients
to
regulate
nutrient-specific
feeding
behavior
remains
elusive.
Here,
we
show
that
in
female
Drosophila,
pair
dopaminergic
neurons,
tritocerebrum
1-dopaminergic
neurons
(T1-DANs),
are
directly
activated
by
protein-intake-induced
signal
from
insulin-producing
cells
(IPCs).
Intriguingly,
opto-activating
IPCs
elicits
inhibition
both
protein
and
sugar,
while
silencing
T1-DANs
blocks
this
only
food.
Elevating
signaling
or
these
is
sufficient
mimic
satiety.
Furthermore,
conveyed
local
the
protocerebral
bridge
(PB-LNs)
specifically
suppresses
intake.
Therefore,
our
findings
reveal
brain-derived
encodes
satiety
manner,
shedding
light
functional
specificity
brain
regulating
behaviors.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 2617 - 2639
Published: June 1, 2024
Objective:
To
explored
the
potential
molecular
mechanism
of
Sugemule-4
decoction
(MMS-4D)
in
treating
insomnia.
Methods:
DL
-4-chlorophenylalanine
(PCPA)
+
chronic
unpredictable
mild
stress
stimulation
(CUMS)
was
used
to
induce
an
insomnia
model
rats.
After
successfully
established,
MMS-4D
intervened
at
low,
medium,
and
high
doses
for
7
days.
The
open-field
test
(OFT)
preliminarily
evaluate
efficacy.
investigated
using
gut
microbiota,
serum
metabolomics,
network
pharmacology
(NP).
Experimental
validation
main
components
key
pathways
carried
out
ELISA
Western
blot.
Results:
weights
insomnia-model
rats
were
significantly
raised
(
p
≤
0.05),
total
exercise
distance
OFT
increased
rest
time
shortened,
number
standing
times
after
treatment
with
MMS-4D.
Moreover,
there
a
substantial
recovery
5-HT,
DA,
GABA,
Glu
levels
hypothalamus
tissue
5-HT
GABA
colon
expression
DAT
DRD1
proteins
hippocampus
reduced
drug
treatment.
may
treat
by
regulating
different
crucial
including
-,
DA
Glu-mediated
neuroactive
light
receiver
interaction,
cAMP
signaling
pathway,
serotonergic,
glutamatergic,
dopaminergic,
GABAergic
synapses.
Conclusion:
This
study
revealed
that
can
improve
general
state
behavioral
changes
Its
be
related
reversal
abnormal
mediated
Glu,
such
as
Serotonergic
synapse,
Dopaminergic
Glutamatergic
synapse.
Keywords:
Mongolian
medicine
sugemule-4
decoction,
insomnia,
pharmacology,
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 11, 2024
In
C.
elegans
mechanisms
by
which
peripheral
organs
relay
internal
state
information
to
the
nervous
system
remain
unknown,
although
strong
evidence
suggests
that
such
signals
do
exist.
Here
we
report
discovery
of
a
peptide
ancestral
insulin
superfamily
called
INS-7
functions
as
an
enteroendocrine
and
is
secreted
from
specialized
cells
intestine.
secretion
stimulated
food
withdrawal,
increases
during
fasting
acts
bona
fide
gut-to-brain
attenuates
release
neuropeptide
drives
fat
loss
in
periphery.
Thus,
homeostatic
signal
intestine
gates
neuronal
drive
stimulate
shortage.
Mechanistically,
antagonist
at
canonical
DAF-2
receptor
via
FOXO
AMPK
signaling
ASI
neurons.
Phylogenetic
analysis
bears
greater
resemblance
members
broad
insulin/relaxin
than
conventional
mammalian
IGF
peptides.
The
endogenous
intestinal
with
unexpected
important
properties
its
role
directing
functions.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 15, 2024
Protein-rich
diets
shorten
lifespan
but
increase
fecundity
in
many
organisms.
Animals
actively
adjust
their
feeding
behavior
to
meet
nutritional
requirements.
However,
the
neural
mechanisms
underlying
dynamic
regulation
of
protein
consumption
remain
unclear.
Here
we
find
that
both
sexes
fruit
flies
exhibit
a
preference
for
food
before
mating
prepare
reproduction.
Mated
female
display
an
increased
appetite
yeast
benefit
offspring,
albeit
at
cost
stress
resistance
and
lifespan.
In
contrast,
males
show
momentarily
reduced
after
likely
restore
fitness.
This
state-dependent
switch
between
is
mediated
by
sexually
dimorphic
circuit
labeled
with
leucokinin
anterior
brain.
Furthermore,
intermittent
benefits
males,
while
maximizing
without
compromising
are
known
enhance
often
reduce
across
various
species.
Here,
authors
demonstrate
undergo
sex-specific
post-mating
dietary
shift
balances
overall
fitness,
regulated
leucokinin-labeled
circuits.
Obesity,
Journal Year:
2023,
Volume and Issue:
31(7), P. 1755 - 1766
Published: May 28, 2023
Abstract
Objective
Although
intake
of
specific
macronutrients
has
been
associated
with
sleep
parameters,
interventional
evidence
is
lacking.
Therefore,
this
randomized
trial
was
conducted
to
examine
how
a
more
unhealthy
high‐fat/high‐sugar
(HFHS)
diet
impacts
in
humans.
Methods
In
crossover
study,
15
healthy
young
men
consumed
two
isocaloric
diets
random
order
for
week:
an
HFHS
and
low‐fat/low‐sugar
diet.
Following
each
diet,
in‐lab
recorded
using
polysomnography
during
full
night
recovery
after
extended
wakefulness.
Sleep
duration,
macrostructure,
microstructure
(oscillatory
pattern
slow
waves)
were
investigated
machine
learning‐based
algorithms.
Results
duration
did
not
differ
across
the
based
on
actigraphy
polysomnography.
macrostructure
similar
1
week
Compared
consumption
resulted
reduced
delta
power,
beta
ratio,
wave
amplitude
but
increased
alpha
theta
power
deep
sleep.
During
sleep,
oscillatory
changes
observed.
Conclusions
Short‐term
alters
features
that
regulate
restorative
properties
Whether
such
can
mediate
adverse
health
outcomes
unhealthier
warrants
investigation.
Current Treatment Options in Gastroenterology,
Journal Year:
2023,
Volume and Issue:
21(4), P. 435 - 446
Published: Oct. 9, 2023
Abstract
Purpose
of
review
This
outlines
the
relationship
between
sleep
and
GI
tract
in
health,
before
appraising
association
disease,
namely
disorders
gut-brain
interaction
(DGBI).
We
aim
to
explore
whether
disturbance
exacerbates
DGBI
symptoms
or
vice
versa,
summarise
evidence
for
pharmacological
psychological
treatment
options.
Recent
findings
Sleep
are
more
common
patients
with
irritable
bowel
syndrome
(IBS)
compared
healthy
subjects,
a
pooled
prevalence
37.6%.
Sufficient
exists
support
use
melatonin
ameliorate
overall
IBS
symptom
severity
improve
quality
life.
Summary
DGBIs
stress-sensitive
simple
lifestyle
advice
is
recognised
as
first-line
management.
Sleep,
cornerstone
management,
appears
be
forgotten
factor.
(both
duration
quality)
has
been
associated
DGBI,
IBS;
however,
further
studies
required
determine
options
targeted
at
can
lead
improvement.
