Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 28, 2024
Distant
metastasis
is
the
leading
cause
of
cancer-related
mortality,
and
achieving
survival
benefits
through
advancements
in
systemic
therapy
remains
challenging.
Mast
cells
play
a
dual
role
shaping
tumor
microenvironment
(TME)
influencing
distant
metastasis,
underscoring
significant
research
value
targeting
mast
for
advanced
cancer.
We
investigated
variations
cell
infiltration
levels
primary
metastatic
malignancies
using
immunocyte
analysis.
subsets
were
identified
from
pan-cancer
single-cell
sequencing
data
dimensionality
reduction
clustering
type
annotation,
combined
with
trajectory
communication
network
analyses.
A
prognostic
model
was
established
WGCNA
12
machine
learning
algorithms
to
identify
potential
targets.
Drug
sensitivity
Mendelian
randomization
analyses
conducted
select
drugs
cells,
their
effects
on
epithelial-mesenchymal
transition
(EMT)
validated
vitro
experiments,
including
wound
healing,
transwell,
western
blot
assays.
Results
revealed
that
activated
show
increased
tumors,
correlating
poor
duration.
XBP1+
as
key
components
inhibitory
TME,
potentially
involved
EMT
activation.
Simvastatin
drug,
reversing
induced
by
pan-cancer.
Aberrant
activation
MEK/ERK
signaling
can
stimulate
cancer
modulating
degranulation,
while
inhibit
suppressing
degranulation.
Science,
Journal Year:
2024,
Volume and Issue:
384(6694)
Published: April 25, 2024
Tubulin,
one
of
the
most
abundant
cytoskeletal
building
blocks,
has
numerous
isotypes
in
metazoans
encoded
by
different
conserved
genes.
Whether
these
distinct
form
cell
type–
and
context-specific
microtubule
structures
is
poorly
understood.
Based
on
a
cohort
12
patients
with
primary
ciliary
dyskinesia
as
well
mouse
mutants,
we
identified
characterized
variants
TUBB4B
isotype
that
specifically
perturbed
centriole
cilium
biogenesis.
Distinct
differentially
affected
dynamics
cilia
formation
dominant-negative
manner.
Structure-function
studies
revealed
disrupted
tubulin
interfaces,
thereby
enabling
stratification
into
three
classes
ciliopathic
diseases.
These
findings
show
specific
have
nonredundant
subcellular
functions
establish
link
between
tubulinopathies
ciliopathies.
Cancer Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Combining
immune
checkpoint
blockade
(ICB)
with
chemotherapy
shows
promise
for
treating
triple-negative
breast
cancer
(TNBC),
though
the
mechanisms
remain
incompletely
understood.
Here,
we
integrate
published
and
new
single-cell
RNA
sequencing
(scRNA-seq)
data
to
investigate
tumor
microenvironment
(TIME)
in
TNBC
patients
treated
paclitaxel
(PTX),
nab-paclitaxel
(Nab-PTX),
their
combinations
anti-PD-L1
antibody
atezolizumab
(ATZ).
Compared
ATZ
plus
PTX,
Nab-PTX
rewires
TCF7+
stem-like
effector
memory
CD8+
T
cells
(Tsem)
CD4+
follicular
helper
(Tfh)
cells.
Nab-paclitaxel,
unlike
also
reshapes
myeloid
compartment,
expanding
mast
pro-inflammatory
macrophages.
Our
analyses
human
murine
models
underscore
crucial
role
of
orchestrating
anti-tumor
responses,
likely
by
promoting
recruitment
activation
B
In
vivo
experiments
demonstrate
that
activating
alongside
PD-L1
attenuates
progression,
suggesting
as
a
promising
adjunct
enhancing
ICB
therapy
efficacy.
Frontiers in Neurology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Cerebrospinal
fluid
(CSF)
dynamics
disorders
are
intricately
linked
to
diverse
neurological
pathologies,
though
they
usually
mild
and
covert.
Contemporary
insights
into
glymphatic
system
function,
particularly
the
CSF
transport,
drainage,
its
role
in
clearing
metabolic
waste
toxic
substances
both
normal
pathological
states,
pivotal
of
aquaporin-4
(AQP4)
CSF-interstitial
(ISF)
exchange,
have
established
novel
theoretical
frameworks
subclinical
dysfunction,
promoted
development
non-surgical
therapeutic
approaches
for
them
simultaneously.
This
review
comprehensively
analyzes
advancement
interventions
disorders,
emphasizing
transition
from
methodologies
innovative
approaches.
Current
treatment
strategies
primarily
encompass
three
directions:
pharmacological
therapy,
physical
biological
regulation
therapy.
In
terms
interventions,
developments
traditional
diuretics
small-molecule
drugs
show
promising
potential.
techniques
such
as
lower
body
negative
pressure,
transcranial
magnetic
stimulation,
vagus
nerve
stimulation
provided
new
options
clinical
practice.
Meanwhile,
exemplified
by
recombinant
VEGF-C
administration,
has
paradigms.
These
demonstrated
potential
improving
enhancing
elimination.
Future
research
should
focus
on
developing
individualized
protocols,
elucidating
mechanisms,
assessing
longitudinal
outcomes.
will
facilitate
more
precise
exploration
optimized
multimodal
combinations
handling
so-called
convert
dysfunction.
American Journal of Cancer Research,
Journal Year:
2024,
Volume and Issue:
14(1), P. 1 - 15
Published: Jan. 1, 2024
Mast
cells
(MCs)
have
emerged
as
pivotal
contributors
to
both
the
defensive
immune
response
and
immunomodulation.
They
also
exhibit
regulatory
functions
in
modulating
pathological
processes
across
various
allergic
diseases.
The
impact
of
MC
presence
within
tumor
tissues
has
garnered
considerable
attention,
yielding
conflicting
findings.
While
some
studies
propose
that
MCs
promote
initiation
progression,
others
advocate
an
opposing
perspective.
Notably,
evidence
emphasizes
dual
role
cancer,
promoters
suppressors,
is
crucial
for
optimizing
cancer
treatment
strategies.
These
viewpoints
generated
substantial
controversy,
underscoring
need
a
comprehensive
understanding
MC's
responses.
Immunology and Cell Biology,
Journal Year:
2024,
Volume and Issue:
102(6), P. 452 - 455
Published: May 7, 2024
In
this
article
for
the
Highlights
of
2023
Series,
we
consider
growing
understanding
mast
cell
heterogeneity
and
interactions
that
has
developed
from
single
RNA
sequencing
studies.
We
also
discuss
novel
concepts
concerning
with
central
nervous
system
evidence
their
role
in
host
defense
against
SARS-CoV-2
infection.
