Symmetry in frontal but not motor and somatosensory cortical projections DOI
Andrew E. Papale,

Madhumita Harish,

Ronald F. Paletzki

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(33), P. e1195232024 - e1195232024

Published: June 27, 2024

The neocortex and striatum are topographically organized for sensory motor functions. While areas lateralized touch control, respectively, frontal involved in decision-making, where lateralization of function may be less important. This study contrasted the topographic precision cell-type–specific ipsilateral contralateral cortical projections while varying injection site location transgenic mice both sexes. had strongly outputs to cortex striatum, they were weaker not as precise targets. somewhat stronger but still relatively weak topography. In contrast, high degrees similarity striatum. Corticothalamic organization is mainly ipsilateral, with weaker, more medial projections. Corticostriatal computations might integrate input outside closed basal ganglia loops using projections, enabling two hemispheres act a unit converge on one result planning decision-making.

Language: Английский

Cross-hemispheric communication: Insights on lateralized brain functions DOI
Sebastian Ocklenburg, Zengcai V. Guo

Neuron, Journal Year: 2024, Volume and Issue: 112(8), P. 1222 - 1234

Published: March 7, 2024

Language: Английский

Citations

18
Brain-wide dynamics linking sensation to action during decision-making DOI Creative Commons
Andrei Khilkevich, Michael Lohse, Ryan Low

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Language: Английский

Citations

15
Separating cognitive and motor processes in the behaving mouse DOI
Munib A. Hasnain, Jaclyn E Birnbaum,

Juan Luis Ugarte Nunez

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

1
PhysMAP - interpretablein vivoneuronal cell type identification using multi-modal analysis of electrophysiological data DOI Creative Commons
Eric Lee,

Asım Emre Gül,

Greggory Heller

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Abstract Cells of different types perform diverse computations and coordinate their activity during sensation, perception, action. While electrophysiological approaches can measure the many neurons simultaneously, assigning cell type labels to these is an open problem. Here, we develop PhysMAP, a framework that weighs multiple modalities simultaneously in unsupervised manner obtain interpretable representation separates by type. PhysMAP superior any single modality identifying neuronal such as excitatory pyramidal, PV + interneurons, SOM interneurons with high confidence both juxtacellular extracellular recordings from areas mouse brain. built on ground truth data be used for classifying new existing datasets, thus facilitate simultaneous assessment coordinated dynamics behavior.

Language: Английский

Citations

6
Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components DOI Open Access
Mattias Horan, Daniel Regester, Cristina Mazuski

et al.

Published: July 8, 2024

Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile high-density electrophysiology. Here we developed, deployed, evaluated real-world performance Repix, a implantation system permits repeated re-use probes. The lightweight allows implanted animals to express full range natural behaviors, including social behaviors. We show Repix across many months, up year, implants cortical subcortical brain regions. Probes reused repeatedly stable yield. has been used by 16 researchers 10 laboratories date, variety paradigms both mice rats combined 209 implantations. found key advantage robustness simplicity. Adopters became proficient at five procedures on average, regardless vivo With companion protocol alongside this article, user-friendliness should facilitate wide uptake recordings.

Language: Английский

Citations

6
Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings DOI Creative Commons
Ye Z, Andrew M. Shelton, Jordan R Shaker

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 24, 2023

To understand the neural basis of behavior, it is essential to sensitively and accurately measure activity at single neuron spike resolution. Extracellular electrophysiology delivers this, but has biases in neurons detects imperfectly resolves their action potentials. minimize these limitations, we developed a silicon probe with much smaller denser recording sites than previous designs, called Neuropixels Ultra (

Language: Английский

Citations

16
Superior colliculus bidirectionally modulates choice activity in frontal cortex DOI Creative Commons
Alyse M. Thomas, Weiguo Yang, Catherine Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 14, 2023

Abstract Action selection occurs through competition between potential choice options. Neural correlates of are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate remains unresolved. Here we report that SC can bidirectionally modulate drive activity in cortex. In the mouse, topographically matched formed a descending motor pathway for directional licking re-entrant loop via thalamus. During distinct neuronal populations both encoded opposing lick directions exhibited competitive interactions. GABAergic neurons ipsilateral locally inhibited glutamatergic contralateral choice. Activating or suppressing cell types could These results thus identify as major locus within broader action network.

Language: Английский

Citations

13
Brain mechanism of foraging: Reward-dependent synaptic plasticity versus neural integration of values DOI
Ulises Pereira-Obilinovic, Han Hou, Karel Svoboda

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(14)

Published: March 29, 2024

During foraging behavior, action values are persistently encoded in neural activity and updated depending on the history of choice outcomes. What is mechanism for value maintenance updating? Here, we explore two contrasting network models: synaptic learning versus integration. We show that both models can reproduce extant experimental data, but they yield distinct predictions about underlying biological circuits. In particular, integrator model not requires reward signals mediated by pools selective alternatives their projections aligned with linear attractor axes valuation system. demonstrate experimentally observable dynamical signatures feasible perturbations to differentiate scenarios, suggesting a more robust candidate mechanism. Overall, this work provides modeling framework guide future research probabilistic foraging.

Language: Английский

Citations

4
SHIELD: Skull-shaped hemispheric implants enabling large-scale electrophysiology datasets in the mouse brain DOI
Corbett Bennett,

Ben Ouellette,

Tamina K. Ramirez

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(17), P. 2869 - 2885.e8

Published: July 11, 2024

Language: Английский

Citations

4
Analysis methods for large-scale neuronal recordings DOI
Carsen Stringer, Marius Pachitariu

Science, Journal Year: 2024, Volume and Issue: 386(6722)

Published: Nov. 7, 2024

Simultaneous recordings from hundreds or thousands of neurons are becoming routine because innovations in instrumentation, molecular tools, and data processing software. Such can be analyzed with science methods, but it is not immediately clear what methods to use how adapt them for neuroscience applications. We review, categorize, illustrate diverse analysis neural population describe these have been used make progress on longstanding questions neuroscience. review a variety approaches, ranging the mathematically simple complex, exploratory hypothesis-driven, recently developed more established methods. also some common statistical pitfalls analyzing large-scale data.

Language: Английский

Citations

4