Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 16, 2025
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
The intestinal epithelium, beyond its role in absorption and digestion, serves as a critical protective mechanical barrier that delineates the luminal contents gut microbiota from lamina propria within resident mucosal immune cells to maintain homeostasis. is manifested contiguous monolayer of specialized epithelial (IEC), interconnected through tight junctions (TJs). integrity this paramount. Consequently, excessive IEC death advances permeability consequence thereof translocation bacteria into propria, subsequently triggering an inflammatory response, which underpins clinical disease trajectory bowel (IBD). A burgeoning body evidence illustrates landscape where undergoes several model programmed cell (PCD) pathophysiology pathogenesis IBD. Apoptosis, necroptosis, pyroptosis represent principal modalities PCD with intricate specific pathways molecules. Ample has revealed substantial mechanistic convergence crosstalk among these three aforementioned forms death, expanding conceptualization PANoptosis orchestrated by PNAoptosome complex. This review provides concise overview molecular mechanisms apoptosis, pyroptosis. Furthermore, based on between deaths IEC, details current knowledge regarding regulation natural products. Our objective broaden comprehension innovative underlying IBD furnish foundation for developing more drugs treatment IBD, benefiting both practitioners research workers.
Language: Английский
Citations
3
Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(9), P. 1420 - 1433
Published: Sept. 1, 2024
Language: Английский
Citations
12
Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Summary Inflammasomes are multi‐protein complexes that assemble within the cytoplasm of mammalian cells in response to pathogen‐associated molecular patterns (PAMPs) or damage‐associated (DAMPs), driving secretion pro‐inflammatory cytokines IL‐1β and IL‐18, pyroptosis. The best‐characterized inflammasome NLRP3, NAIP‐NLRC4, NLRP1, AIM2, Pyrin canonical caspase‐1‐containing inflammasomes, caspase‐11 non‐canonical inflammasome. Newer sensor proteins have been identified, including NLRP6, NLRP7, NLRP9, NLRP10, NLRP11, NLRP12, CARD8, MxA. These sensors can sense PAMPs from bacteria, viruses protozoa, DAMPs form mitochondrial damage, ROS, stress heme. mechanisms action, physiological relevance, consequences human diseases, avenues for therapeutic intervention these novel inflammasomes beginning be realized. Here, we discuss emerging their putative activation mechanisms, signaling pathways, roles health disease.
Language: Английский
Citations
9
Pathogens, Journal Year: 2025, Volume and Issue: 14(1), P. 43 - 43
Published: Jan. 8, 2025
PANoptosis is a newly identified programmed cell death pathway that integrates characteristics of apoptosis, pyroptosis, and necroptosis. It plays dual role in the host immune response to bacterial infections. On one hand, acts as protective mechanism by inducing infected cells eliminate pathogens releasing pro-inflammatory cytokines amplify response. other bacteria can exploit evade defenses. This nature underscores potential target for developing novel therapies against review summarizes molecular mechanisms PANoptosis, along with crosstalk integration different pathways various pathogens. We also discuss roles infectious diseases, including sepsis, pulmonary infections, intestinal Elucidating underlying how manipulate this offers critical insights into host-pathogen interactions. These provide foundation designing targeted antibacterial strategies, modulating inflammation, advancing precision medicine improve clinical outcomes.
Language: Английский
Citations
1
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
1
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 768, P. 110385 - 110385
Published: March 12, 2025
Language: Английский
Citations
1
Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122962 - 122962
Published: Nov. 12, 2024
Language: Английский
Citations
5
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102629 - 102629
Published: Dec. 5, 2024
Language: Английский
Citations
5
Current Opinion in Immunology, Journal Year: 2024, Volume and Issue: 91, P. 102489 - 102489
Published: Sept. 27, 2024
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 31, 2024
PANoptosis is a newly identified inflammatory programmed cell death (PCD) that involves the interplay of apoptosis, necrosis, and pyroptosis. However, its overall biological effects cannot be attributed to any one type PCD alone. regulated by signaling cascade triggered recognition pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs) various sensors. This triggers assembly PANoptosome, which integrates key components from other pathways via adapters ultimately activates downstream execution molecules, resulting in with necrotic, apoptotic, pyroptotic features. Autoimmune diseases are characterized reduced immune tolerance self-antigens, leading abnormal responses, often accompanied systemic chronic inflammation. Consequently, PANoptosis, as unique innate immune-inflammatory pathway, has significant pathophysiological relevance inflammation autoimmunity. most previous research on focused tumors infectious diseases, leaving activation role autoimmune unclear. review briefly outlines characteristics summarizes several PANoptosome complexes, their mechanisms, components. We also explored dual potential therapeutic approaches targeting PANoptosis. Additionally, we existing evidence for explore regulatory mechanisms involved.
Language: Английский
Citations
4