Harnessing gut microbial communities to unravel microbiome functions

Current Opinion in Microbiology, Journal Year: 2025, Volume and Issue: 83, P. 102578 - 102578

Published: Jan. 8, 2025

Language: Английский

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Does Gut Microbiome Composition Influence the Efficacy of Psychiatric Drugs?

European Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Altered gut microbiome profiles correlate with anxiety and depression in humans, work animal models has identified specific bacterial taxa and/or microbiome-derived metabolites that influence complex emotional behaviours. Intriguingly, many pharmaceuticals, including widely used oral treatments for depression, can be chemically modified by microbes the gastrointestinal tract, which may lead to drug inactivation. The authors highlight importance of integrating research across microbial culture systems, models, multi-omics analyses clinical cohorts gain mechanistic insights into whether composition determines efficacy, bioavailability, tolerability neuropsychiatric medications. This hypothesis, if validated, have profound implications personalised treatment plans microbiome-based biomarker development.

Language: Английский

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Moving from genome-scale to community-scale metabolic models for the human gut microbiome

Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Parkinson’s drug starves gut microbes of iron

Nature Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Language: Английский

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