The role of the microbiota-gut-brain axis and artificial intelligence in cognitive health of pediatric obstructive sleep apnea: A narrative review DOI Creative Commons
Yong Lv, Yan‐Fang Xian, Xiaoyan Lei

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(50), P. e40900 - e40900

Published: Dec. 13, 2024

Pediatric obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder associated with significant neurocognitive and behavioral impairments. Recent studies have highlighted the role of gut microbiota microbiota-gut-brain axis (MGBA) in influencing cognitive health children OSA. This narrative review aims to summarize current knowledge on relationship between microbiota, MGBA, function pediatric It also explores potential artificial intelligence machine learning advancing this field identifying novel therapeutic strategies. OSA dysbiosis, reduced microbial diversity, metabolic disruptions. MGBA mechanisms, such as endocrine, immune, neural pathways, link outcomes. Artificial methodologies offer promising tools uncover markers mechanisms deficits Future research should focus validating these findings through clinical trials developing personalized approaches targeting microbiota.

Language: Английский

Advances in polysaccharide-based probiotic delivery systems: A review DOI Creative Commons
Jie Cheng, Xianping Li, T. Tony Ke

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100804 - 100804

Published: April 1, 2025

Language: Английский

Citations

0
IUPHAR Themed Review: The Gut Microbiome in Schizophrenia DOI Creative Commons
Srinivas Kamath,

Elysia Sokolenko,

Kate Collins

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107561 - 107561

Published: Dec. 1, 2024

Gut microbial dysbiosis or altered gut consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, cognitive symptoms. Paradoxically, conventional psychotropic interventions may exacerbate this dysbiosis, with antipsychotics, particularly olanzapine, demonstrating profound effects on architecture disruption of bacterial phyla ratios, diminished taxonomic diversity, attenuated short-chain fatty acid synthesis. To address these challenges, novel therapeutic strategies targeting microbiome, encompassing probiotic supplementation, prebiotic compounds, faecal microbiota transplantation, rationalised co-pharmacotherapy, show promise attenuating antipsychotic-induced metabolic disruptions while enhancing efficacy. Harnessing such insights, precision medicine approaches transform antipsychotic prescribing practices by identifying patients at risk side based their profiles. This IUPHAR review collates current literature landscape axis its intricate relationship advocating for integrating microbiome assessments management. Such fundamental shift proposing microbiome-informed prescriptions optimise efficacy reduce adverse impacts would align treatments safety, prioritising 'gut-neutral' gut-favourable drugs safeguard long-term patient outcomes therapy.

Language: Английский

Citations

2
Asiaticoside improves depressive-like behavior in mice with chronic unpredictable mild stress through modulation of the gut microbiota DOI Creative Commons

Qingyi Ren,

Chenxi He,

Yuhong Sun

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background Asiaticoside, the main active ingredient of Centella asiatica, is a pentacyclic triterpenoid compound. Previous studies have suggested that asiaticoside possesses neuroprotective and anti-depressive properties, however, mechanism its anti-depressant action not fully understood. In recent years, growing body research on anti-depressants has focused microbiota-gut-brain axis, we noted disruption gut microbial community structure diversity can induce or exacerbate depression, which plays key role in regulation depression. Methods Behavioral experiments were conducted to detect depression-like behavior mice through sucrose preference, forced swimming, open field tests. Additionally, composition short-chain fatty acid (SCFA) levels mouse feces analyzed 16S rRNA sequencing gas chromatography-mass spectrometry (GC-MS). Hippocampal brain-derived neurotrophic factor (BDNF) 5-hydroxytryptamine receptor 1A (5-HT1A) expression was assessed by western blotting. Changes serum inflammatory factors, neurotransmitters, hormones measured using ELISA. Results This study revealed oral administration significantly improved chronic unpredictable mild stress (CUMS) mice. It partially restored CUMS mice, altered SCFA metabolism, regulated hypothalamic–pituitary–adrenal axis (HPA axis) levels, upregulated BDNF 5-HT1A protein expression, increased serotonin (5-hydroxytryptamine, 5-HT) concentration. These findings reveal exerts antidepressant effects via axis. Conclusions results model.

Language: Английский

Citations

1
The role of the microbiota-gut-brain axis and artificial intelligence in cognitive health of pediatric obstructive sleep apnea: A narrative review DOI Creative Commons
Yong Lv, Yan‐Fang Xian, Xiaoyan Lei

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(50), P. e40900 - e40900

Published: Dec. 13, 2024

Pediatric obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder associated with significant neurocognitive and behavioral impairments. Recent studies have highlighted the role of gut microbiota microbiota-gut-brain axis (MGBA) in influencing cognitive health children OSA. This narrative review aims to summarize current knowledge on relationship between microbiota, MGBA, function pediatric It also explores potential artificial intelligence machine learning advancing this field identifying novel therapeutic strategies. OSA dysbiosis, reduced microbial diversity, metabolic disruptions. MGBA mechanisms, such as endocrine, immune, neural pathways, link outcomes. Artificial methodologies offer promising tools uncover markers mechanisms deficits Future research should focus validating these findings through clinical trials developing personalized approaches targeting microbiota.

Language: Английский

Citations

1