Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain

Journal of Neurochemistry, Journal Year: 2023, Volume and Issue: 166(1), P. 24 - 46

Published: Feb. 18, 2023

Abstract In countries around the world, sleep deprivation represents a widespread problem affecting school‐age children, teenagers, and adults. Acute more chronic restriction adversely affect individual health, impairing memory cognitive performance as well increasing risk progression of numerous diseases. mammals, hippocampus hippocampus‐dependent are vulnerable to effects acute deprivation. Sleep induces changes in molecular signaling, gene expression may cause dendritic structure neurons. Genome wide studies have shown that alters transcription, although pool genes affected varies between brain regions. More recently, advances research drawn attention differences regulation level transcriptome compared with mRNA associated ribosomes for protein translation following Thus, addition transcriptional changes, also affects downstream processes alter translation. this review, we focus on multiple levels through which impacts regulation, highlighting potential post‐transcriptional translational be by Understanding impacted is essential future development therapeutics mitigate loss. image

Language: Английский

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Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2040)

Published: Feb. 1, 2025

Biological clocks are a ubiquitous feature of all life, enabling the use natural environmental cycles to track time. Although studies on circadian rhythms have contributed greatly knowledge chronobiology, biological in dark biospheres such as deep sea remain poorly understood. Here, based free-running experiment laboratory, we reveal potentially endogenous gene expression deep-sea hydrothermal vent shrimp Rimicaris leurokolos . Oscillations with approximately 12 h periods, probably reflecting tidal influence, prevail over others temporal transcriptome, indicating R. depends circatidal clock consisting at least some components independent from clocks. The transcripts exhibit an antiphased pattern divided into two internally synchronized clusters, correlated wide-ranging processes that occur nucleus and cytoplasm, respectively. In addition, showed great similarities genes fruit flies mice exhibiting ultradian rhythms, tide had broad impact evolution oscillations found across Metazoa. These findings not only provide new insights adaptations organisms but also highlight intriguing models for chronobiological studies, particularly those linked rhythms.

Language: Английский

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Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

Cells, Journal Year: 2022, Volume and Issue: 11(12), P. 1930 - 1930

Published: June 15, 2022

Cancer is one of the most common causes death; in parallel, incidence and prevalence central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia common, while Parkinson’s disease (PD) second frequent disease. There a significant amount evidence on complex biological connection between cancer neurodegeneration. Noncoding RNAs (ncRNAs) defined as transcribed nucleotides that perform variety regulatory functions. The mechanisms by which ncRNAs exert their functions numerous involve every aspect cellular life. same ncRNA can act multiple ways, leading to different outcomes; fact, single participate pathogenesis more than disease—even if these seem very different, disorders are. activates specific pathways or other clinical phenotype, sometimes with obvious inverse comorbidity. We aimed collect from existing literature examples comorbidity play key role. also investigated example mir-519a-3p, its target genes Poly (ADP-ribose) polymerase 1, for mechanism some cancers PD. believe it important study relationship because will help us better assess two major areas human

Language: Английский

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Circadian Regulation of Macrophages and Osteoclasts in Rheumatoid Arthritis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12307 - 12307

Published: Aug. 1, 2023

Rheumatoid arthritis (RA) represents one of the best examples circadian fluctuations in disease severity. Patients with RA experience stiffness, pain, and swelling afflicted joints early morning, which tends to become milder toward afternoon. This has been primarily explained by higher blood levels pro-inflammatory hormones cytokines, such as melatonin, TNFα, IL-1, IL-6, morning than afternoon well insufficient anti-inflammatory cortisol, rises later morning. Clinical importance regulation symptoms demonstrated effectiveness time-of-day-dependent delivery therapeutic agents chronotherapy. The primary inflammatory site is synovium, where increased macrophages, T cells, synovial fibroblasts play central roles secreting chemokines, enzymes stimulate each other, additional immune osteoclasts, ultimately leading cartilage bone erosion. Among these players, macrophages have prime targets for study link between rhythms activities. Gene knockout experiments various core regulators established that disruption any results hyper- or hypoactivation responses when challenged lipopolysaccharide bacteria. Although stimulations are not directly linked etiology, findings serve a foundation further providing proof principle. On other hand, downstream effectors remain under-explored. Nonetheless, expression inducers osteoclastogenesis, phenotypes osteoclasts suggest significance control osteoclast activity pathogenesis RA. More detailed mechanistic understanding could add novel local options

Language: Английский

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Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(1), P. e1011545 - e1011545

Published: Jan. 8, 2025

A key property of the circadian clock is that it reset by light to remain synchronized with day-night cycle. An attractive model explore input in vertebrates zebrafish. Circadian clocks zebrafish peripheral tissues and even zebrafish-derived cell lines are entrainable direct exposure thus providing unique insight into function evolution regulatory pathways. Our previous work has revealed light-induced gene transcription a step entrainment as well enabling more general adaptation cells sunlight exposure. However, considerable evidence points post-transcriptional mechanisms, notably microRNAs (miRNAs), playing an essential role shaping dynamic changes mRNA levels. Therefore, does directly impact miRNAs? Are there light-regulated miRNAs if so, which classes do they target? To address these questions, we performed complete sequencing analysis transcriptome, encompassing small non-coding RNAs mRNAs. Importantly, identified sets miRNAs, many targets representing light-inducible mRNAs including genes involved redox homeostasis. We subsequently focused on light-responsive miR-204-3-3p miR-430a-3p predicted regulate expression cryptochrome ( cry1a cry1b ). Luciferase reporter assays validated target binding 3′UTRs , respectively. Furthermore, treatment mimics inhibitors two significantly affected their but also other core components clock1a bmal1b per1b per2 per3 ), rhythmic locomotor activity larvae. Thus, our identification reveals new intricacy multi-level regulation clockwork light.

Language: Английский

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Daily proteome variations highlight sustained metabolic activity in cone cells of Nrl knockout mice

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110284 - 110284

Published: Feb. 1, 2025

Language: Английский

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The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 29, 2025

Abstract Sleep is an indispensable physiological function regulated by circadian rhythms, which influence the biological pathways and overall health of body. crucial for maintenance restoration bodily systems, disturbances can lead to various sleep disorders, impair both mental physical health. Treatment options these disorders encompass lifestyle modifications, psychotherapy, medications, therapies such as light therapy surgery. Not only deprivation has a significant impact on essential organs, but it also influences types stem cells in In this review, we explore connection between cells, highlighting how rhythms regulate cell activities that are vital tissue regeneration homeostasis. Disruptions hinder self-renewal, homing, proliferation, function, differentiation, thereby affecting We discuss transplantation their products may help improve quality affects behavior, implications therapies. Notably, while certain transplantations disrupt sleep, enhancing efficacy Finally, be utilized model offering valuable insights into underlying mechanisms.

Language: Английский

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Contribution of membrane-associated oscillators to biological timing at different timescales

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 9, 2024

Environmental rhythms such as the daily light-dark cycle selected for endogenous clocks. These clocks predict regular environmental changes and provide basis well-timed adaptive homeostasis in physiology behavior of organisms. Endogenous are oscillators that based on positive feedforward negative feedback loops. They generate stable even under constant conditions. Since weak interactions between allow autonomous synchronization, coupling/synchronization provides self-organized physiological timing. Amongst most thoroughly researched circadian clock neurons mammals insects. comprise nuclear clockworks transcriptional/translational loops (TTFL) ∼24 h gene expression entrained to day-night cycle. It is generally assumed this TTFL clockwork drives all oscillations within cells, being any rhythm Instead current gene-based hierarchical model we here a systems view We suggest coupled system posttranslational loop (PTFL) oscillators/clocks run at multiple timescales governs adaptive, dynamic behavior. focus mammalian insect timescales. neuronal plasma membrane-associated signalosomes constitute specific PTFL localized but interlinked membrane potential intracellular messengers with frequencies. In each neuron multiscale form temporally structured oscillatory network common complex frequency-band comprising superimposed oscillations. Coupling oscillator/clock next level complexity an network. This systemic molecular cellular suggested cycles through homeostatic setpoints characteristic hallmark. propose mechanisms plasticity maintain stability these setpoints, whereas Hebbian enables switching via coupling factors, like biogenic amines and/or neuropeptides. reprogram new frequency, setpoint. Our novel hypothesis up experimental challenge.

Language: Английский

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Aryl hydrocarbon receptor impairs circadian regulation in Alzheimer's disease: Potential impact on glymphatic system dysfunction

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(2), P. 3901 - 3920

Published: June 25, 2024

Circadian clocks maintain diurnal rhythms of sleep-wake cycle 24 h that regulate not only the metabolism an organism but also many other periodical processes. There is substantial evidence circadian regulation impaired in Alzheimer's disease. properties known to be disturbed patients, such as integrity blood-brain barrier (BBB) well glymphatic flow controls waste clearance from brain. Interestingly, evolutionarily conserved transcription factor, is, aryl hydrocarbon receptor (AhR), impairs function core clock proteins and thus could disturb rhythmicity BBB. abundant activation AhR signalling inhibits expression major proteins, brain muscle arnt-like 1 (BMAL1), regulator (CLOCK) period (PER1) different experimental models. The robustly increased brains protein level enriched astrocytes It seems since it (i) BBB, which cooperatively interconnected with system brain, (ii) neuroinflammation dysbiosis gut microbiota generate potent activators AhR, are able impair flow. I will examine current indicating functions BBB involved development pathology.

Language: Английский

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Evolved Loss of Sleep and Circadian Rhythms in Cavefish

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 157

Published: Jan. 1, 2024

Language: Английский

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