Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
16(3), P. 1008 - 1019
Published: Dec. 31, 2024
The
ADAMTS
(a
disintegrin
and
metalloproteinase
with
thrombospondin
motifs)
family
of
metalloproteinases
plays
a
vital
role
in
various
biological
pathological
processes,
including
tissue
remodeling,
angiogenesis,
cancer
progression.Among
the
19
members,
our
research
focused
on
ADAMTS7,
which
exhibited
significant
overexpression
gastric
(GC).This
was
strongly
correlated
poor
clinical
outcomes,
reduced
overall
survival
heightened
metastatic
potential.To
investigate
ADAMTS7
GC,
we
employed
an
integrated
approach
encompassing
bioinformatics
analysis,
Western
blotting,
immunofluorescence,
as
well
vitro
vivo
functional
analyses.Our
results
showed
that
silencing
expression
significantly
inhibited
proliferation,
migration,
invasion
GC
cells,
furthermore,
growth
metastasis
tumour
cells
nude
mice,
highlighting
its
critical
driving
malignant
behaviour
cells.Further
mechanistic
studies
identified
NF-κB
signaling
pathway
key
downstream
target
resulting
notable
reduction
activity.These
findings
establish
contributor
to
aggressiveness
pivotal
activator
pathway,
major
regulator
inflammation
tumor
progression.Consequently,
emerges
promising
therapeutic
prognostic
biomarker
for
GC.Our
study
opens
new
avenues
development
targeted
therapies
aimed
at
inhibiting
activity,
thereby
potentially
improving
treatment
outcomes
rates
patients
GC.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(1), P. 23 - 23
Published: Jan. 18, 2024
Male
infertility,
age-related
changes,
and
tumors
have
been
increasingly
studied
in
the
field
of
male
reproductive
health
due
to
emergence
environmental
stressors,
declining
fertility
rates,
aging
populations.
Numerous
studies
demonstrated
that
ERK1/2
signaling
pathway
plays
a
significant
role
reproduction.
The
is
associated
with
several
pathways
has
complex
interplay
influences
spermatogenic
microenvironment,
sperm
viability,
gonadal
axis
regulation,
as
well
resistance
testicular
tumors.
Moreover,
directly
or
indirectly
regulates
somatic
cells,
which
are
crucial
for
maintaining
spermatogenesis
microenvironment
regulation.
Given
critical
health,
comprehensive
exploration
its
multifaceted
effects
on
reproduction
underlying
mechanisms
necessary.
This
study
aims
provide
solid
foundation
in-depth
research
further
enhance
males.
International Journal of Surgical Pathology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Hemosiderotic
fibrolipomatous
tumor
(HFLT)
and
myxoinflammatory
fibroblastic
sarcoma
(MIFS)
are
rare,
locally
aggressive
soft
tissue
tumors
with
a
predilection
for
distal
extremities
of
middle-aged
adults.
Hybrid
(HFLT-MIFS)
demonstrate
overlapping
features
both
share
recurrent
translocation
(1;10)
(p22;
q24).
We
describe
high-grade
sarcomatous
transformation
hybrid
HFLT-MIFS,
novel
ADAMTS12::TERT
gene
fusion,
presenting
as
right
foot
mass
in
an
85-year-old
woman.
Histologically,
the
showed
areas
HFLT-MIFS
subsequent
resection.
The
patient
was
treated
surgically
below-knee
amputation
interval
radiation
therapy.
On
RNA-based
next-generation
sequencing,
harbored
fusion.
In
addition
to
reporting
fusion
rare
example
transformation,
we
also
discuss
relevant
morphological
HFLT
provide
brief
review
reported
neoplasms
TERT
fusions.
International Journal of Biological Sciences,
Journal Year:
2025,
Volume and Issue:
21(4), P. 1784 - 1800
Published: Feb. 10, 2025
Background:
While
a
role
for
the
E3
ubiquitin
ligase
MAEA
(macrophage
erythroblast
attacher)
has
been
reported
in
several
cancer
types,
its
importance
and
mechanistic
functions
gastrointestinal
(GIC)
have
yet
to
be
established.
Methods:
The
of
GIC
were
explored
through
vitro
vivo
experiments,
including
loss-
gain-of-function
analyses.
Mass
spectrometry
was
used
identify
proteins
that
interact
with
MAEA.
mechanisms
which
influences
tumor
aggression
examined
immunoprecipitation
Results:
patients
exhibiting
reduced
expression
found
exhibit
worse
disease-free
overall
survival
outcomes.
impair
proliferation
chemoresistance
tumors
subcutaneous
xenograft
model
systems.
combination
PARP1
inhibitor
veliparib
resulted
enhanced
oxaliplatin
treatment
efficacy
vivo.
From
perspective,
mediate
K48-linked
ubiquitination
degradation
PARP1,
addition
suppressing
M2
polarization
macrophages
enhancing
macrophage
phagocytic
activity.
Conclusions:
These
data
suggest
offers
value
as
prognostic
biomarker
target
owing
ability
degrade
augment
activity
macrophages.
