Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 15, 2024

The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction a critical factor in etiology progression these disorders. Therapeutic interventions that incorporate mitochondrial transplantation exhibit considerable promise by increasing numbers improving their functionality. Existing evidence suggests exogenous therapy improves clinical outcomes patients with diseases. This review elucidates abnormalities associated diseases examines mechanisms intercellular transfer artificial transplantation. Furthermore, therapeutic strategies are synthesized, concept engineered proposed.

Language: Английский

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BQU57 suppresses IL-1β-induced apoptosis and extracellular matrix degradation in nucleus pulposus cells by blocking the NF-κB signaling pathway

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111729 - 111729

Published: March 1, 2025

Language: Английский

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Lipid metabolic disorders and their impact on cartilage endplate and nucleus pulposus function in intervertebral disk degeneration

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Lipid metabolism encompasses the processes of digestion, absorption, synthesis, and degradation fats within biological systems, playing a crucial role in sustaining normal physiological functions. Disorders lipid metabolism, characterized by abnormal blood levels dysregulated fatty acid have emerged as significant contributors to intervertebral disk degeneration (IDD). The pathogenesis IDD is multifaceted, encompassing genetic predispositions, nutritional metabolic factors, mechanical stressors, trauma, inflammatory responses, which collectively facilitate progression IDD. Although precise mechanisms underlying remain incompletely elucidated, there substantial consensus regarding close association between disorders its development. Intervertebral disks are essential for maintaining spinal alignment. Their primary functions encompass shock preservation curvature, facilitation movement, provision stability. elasticity thickness these effectively absorb daily impacts, safeguard spine, uphold natural curvature flexibility, while also creating space nerve roots prevent compression ensure transmission signals. Research indicates that such disturbances may compromise functionality cartilaginous endplates (CEP) nucleus pulposus (NP), thereby facilitating IDD’s onset progression. CEP integral internal material exchange absorption mitigating NP herniation under load conditions. As central component disks, height providing shock-absorbing capabilities; thus, damage critical structures accelerates Furthermore, contribute through including activation endoplasmic reticulum stress pathways, enhancement oxidative levels, induction cellular pyroptosis alongside inhibition autophagy processes—coupled with promotion inflammation-induced fibrosis fibroblast proliferation leading calcification disks. This review delineates intricate interplay IDD; it anticipated advancing our understanding this will pave way more effective preventive measures therapeutic strategies against future research.

Language: Английский

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The Role of Mitochondrial Dysfunction-Mediated Changes in Immune Cytokine Expression in the Pathophysiology and Treatment of Major Depressive Disorder

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

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Platelet Extracellular Vesicles as Natural Delivery Vehicles for Mitochondrial Dysfunction Therapy?

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Mitochondria are vital for energy production, metabolic regulation, and cellular signaling. Their dysfunction is strongly implicated in neurological, cardiovascular, muscular degenerative diseases, where deficits oxidative stress accelerate disease progression. Platelet extracellular vesicles (PEVs), once called "platelet dust", have emerged as promising agents mitigating mitochondrial dysfunction. Like other (EVs), PEVs carry diverse molecular cargo surface markers processes therapeutic efficacy. Notably, they may possibly contain intact or partially functional components, making them tentatively attractive targeting damage. Although direct research on PEVs-mediated rescue remains limited, current evidence suggests that can modulate diseases associated with potentially enhance health. This review explores the potential of neurodegenerative cardiovascular disorders, highlighting their role restoring By examining recent advancements research, we aim to shed light novel strategies utilizing agents. Our goal underscore importance further fundamental applied into PEVs-based interventions, innovative tools combating a wide range linked

Language: Английский

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Unveiling the role of CXCL8/CXCR2 in intervertebral disc degeneration: A path to promising therapeutic strategies

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 49, P. 119 - 134

Published: Oct. 9, 2024

Language: Английский

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Daphnetin ameliorates intervertebral disc degeneration via the Keap1/Nrf2/NF-κB axis in vitro and in vivo

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113785 - 113785

Published: Dec. 12, 2024

Language: Английский

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Transcriptome Data Combined With Mendelian Randomization Analysis Identifies Key Genes Associated With Mitochondria and Programmed Cell Death in Intervertebral Disc Degeneration

JOR Spine, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 1, 2025

ABSTRACT Background Intervertebral disc degeneration (IDD) is a major cause of cervical and lumbar diseases, significantly impacting patients' quality life. Mitochondria cell death have been implicated in IDD, but the key related genes remain unknown. Methods Differentially expressed (DEGs) between IDD control samples were identified using GSE70362. Mitochondria‐related (MRGs) programmed death‐related (PCDRGs) intersected with DEGs to find DE‐MRGs DE‐PCDRGs. Weighted gene co‐expression network analysis (WGCNA) module genes, overlap revealed candidate genes. Mendelian randomization (MR) was used determine causally linked IDD. Machine learning expression validation further refined which then build nomogram predict risk. Additionally, set enrichment (GSEA), immune infiltration, single‐cell performed. Results A total 515 224 yielding 31 Six genes—BCKDHB, BID, TNFAIP6, VRK1, CAB39L, TMTC1—showed causal relationship TMTC1 as through machine validation. developed based on these GSEA BID enriched N‐glycan biosynthesis, TNFAIP6 aminoacyl tRNA ribosomal pathways. Activated dendritic cells, CD56dim natural killer monocytes, other cells elevated strongly correlating activated cells. Key at higher levels degraded samples. Conclusion TMTC1, mitochondria offering new insights for diagnosis treatment.

Language: Английский

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Potential of N-acetylcysteine in the management of low back pain: a scoping review of studies in humans and animal models

Brazilian Journal of Medical and Biological Research, Journal Year: 2025, Volume and Issue: 58

Published: Jan. 1, 2025

Low back pain (LBP) is a common type of that causes disability and impairs cognitive function. With over 80% adults estimated to experience LBP during their lifetime, this not only has significant impact on the individual, but also public health systems national economies. Unfortunately, there no single standard care for patients with LBP. N-acetylcysteine (NAC), which used clinically treat acetaminophen overdose, recently been tested as potential treatment NAC inexpensive commercially available, it an established tolerance safety profile. However, NAC's efficacy in established. This scoping review presents summary studies investigating effects benefits treatment, highlights its molecular mechanisms side effects. A systematic literature search Pubmed/MEDLINE, Embase, Scopus, Science Direct, Web Science, Cinahl, Lilacs databases was conducted. The PRISMA-ScR checklist ensure integrity review. protocol registered Open Framework. No limit set study language publication date. In total, 2357 articles were located, 16 included. show data are derived from few clinical trials preclinical studies. Thus, much learn more should be performed before can recommended

Language: Английский

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REDOX Imbalance and Oxidative Stress in the Intervertebral Disc: The Effect of Mechanical Stress and Cigarette Smoking on ER Stress and Mitochondrial Dysfunction

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 613 - 613

Published: April 19, 2025

Low back pain is a widespread condition that significantly impacts quality of life, with intervertebral disc degeneration (IDD) being major contributing factor. However, the underlying mechanisms IDD remain poorly understood, necessitating further investigation. Environmental risk factors, such as mechanical stress and cigarette smoke, elevate reactive oxygen species levels from both endogenous exogenous sources, leading to redox imbalance oxidative stress. The endoplasmic reticulum (ER) mitochondria, two key organelles responsible for protein folding energy production, respectively, are particularly vulnerable Under conditions, ER mitochondrial dysfunction occur, resulting in unfolded response activation, impaired biosynthetic processes, disruptions tricarboxylic acid cycle electron transport chain, ultimately compromising metabolism. Prolonged excessive can trigger apoptosis through ER–mitochondrial crosstalk. Given unique microenvironment (IVD)—characterized by hypoxia, glucose starvation, region-specific cellular heterogeneity—the differential effects environmental stressors on distinct IVD cell populations require This review explores potential which factors alter activities, progression, discusses future therapeutic strategies aimed at mitigating degeneration.

Language: Английский

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