Altered RNA Processing in Cancer Pathogenesis and Therapy DOI Open Access
Esther A. Obeng,

Connor Stewart,

Omar Abdel‐Wahab

et al.

Cancer Discovery, Journal Year: 2019, Volume and Issue: 9(11), P. 1493 - 1510

Published: Oct. 14, 2019

Major advances in our understanding of cancer pathogenesis and therapy have come from efforts to catalog genomic alterations cancer. A growing number large-scale studies uncovered mutations that drive by perturbing cotranscriptional post-transcriptional regulation gene expression. These include affect each phase RNA processing, including splicing, transport, editing, decay messenger RNA. The discovery these events illuminates a novel therapeutic vulnerabilities generated aberrant processing cancer, several which progressed clinical development. SIGNIFICANCE: There is increased recognition genetic affecting splicing polyadenylation are common may generate opportunities. Such occur within an individual or factors themselves, thereby influencing many downstream target genes. This review discusses the biological impact on tumorigenesis approaches targeting cells bearing mutations.

Language: Английский

RNA vaccines for cancer: Principles to practice DOI
Pablo Guasp, Charlotte Reiche, Zachary Sethna

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(7), P. 1163 - 1184

Published: June 6, 2024

Language: Английский

Citations

16
p53 at the crossroads of tumor immunity DOI
Gizem Efe, Anil K. Rustgi, Carol Prives

et al.

Nature Cancer, Journal Year: 2024, Volume and Issue: 5(7), P. 983 - 995

Published: July 15, 2024

Language: Английский

Citations

15
Targeting RNA splicing modulation: new perspectives for anticancer strategy? DOI Creative Commons
Xuemei Lv, Xiaoyu Sun, Yang Gao

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 30, 2025

Language: Английский

Citations

2
Molecular profiling of driver events in metastatic uveal melanoma DOI Creative Commons
Joakim Karlsson, Lisa M. Nilsson,

Suman Mitra

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 20, 2020

Abstract Metastatic uveal melanoma is less well understood than its primary counterpart, has a distinct biology compared to skin melanoma, and lacks effective treatments. Here we genomically profile metastatic tumors infiltrating lymphocytes. BAP1 alterations are overrepresented found in 29/32 of cases. Reintroducing functional allele into deficient patient-derived cell line, reveals broad shift towards transcriptomic subtype previously associated with better prognosis the disease. One outlier tumor high mutational burden UV-damage. CDKN2A deletions also occur, which rarely present primaries. A focused knockdown screen used investigate overexpressed genes withcopy number gains. Tumor-infiltrating lymphocytes several cases tumor-reactive, but expression immune checkpoint receptors TIM-3 , TIGIT LAG3 abundant. This study represents largest whole-genome analysis date, presents an updated view

Language: Английский

Citations

135
Altered RNA Processing in Cancer Pathogenesis and Therapy DOI Open Access
Esther A. Obeng,

Connor Stewart,

Omar Abdel‐Wahab

et al.

Cancer Discovery, Journal Year: 2019, Volume and Issue: 9(11), P. 1493 - 1510

Published: Oct. 14, 2019

Major advances in our understanding of cancer pathogenesis and therapy have come from efforts to catalog genomic alterations cancer. A growing number large-scale studies uncovered mutations that drive by perturbing cotranscriptional post-transcriptional regulation gene expression. These include affect each phase RNA processing, including splicing, transport, editing, decay messenger RNA. The discovery these events illuminates a novel therapeutic vulnerabilities generated aberrant processing cancer, several which progressed clinical development. SIGNIFICANCE: There is increased recognition genetic affecting splicing polyadenylation are common may generate opportunities. Such occur within an individual or factors themselves, thereby influencing many downstream target genes. This review discusses the biological impact on tumorigenesis approaches targeting cells bearing mutations.

Language: Английский

Citations

126