Regulation and modulation of biogenic amine neurotransmission in Drosophila and Caenorhabditis elegans DOI Creative Commons

Katarzyna D. Rosikon,

Megan C. Bone,

Hakeem O. Lawal

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 16, 2023

Neurotransmitters are crucial for the relay of signals between neurons and their target. Monoamine neurotransmitters dopamine (DA), serotonin (5-HT), histamine found in both invertebrates mammals known to control key physiological aspects health disease. Others, such as octopamine (OA) tyramine (TA), abundant invertebrates. TA is expressed Caenorhabditis elegans Drosophila melanogaster plays important roles regulation essential life functions each organism. OA thought act mammalian homologs epinephrine norepinephrine respectively, when triggered, they response various stressors fight-or-flight response. 5-HT regulates a wide range behaviors C. including egg-laying, male mating, locomotion, pharyngeal pumping. acts predominantly through its receptors, which classes have been described flies worms. The adult brain composed approximately 80 serotonergic neurons, involved modulation circadian rhythm, feeding, aggression, long-term memory formation. DA major monoamine neurotransmitter that mediates variety critical organismal synaptic transmission it mammals, also precursor synthesis adrenaline noradrenaline. In receptors play generally grouped into two classes, D1-like D2-like based on predicted coupling downstream G proteins. uses photoreceptors well small number CNS. does not use neurotransmitter. Here, we review comprehensive set amine invertebrates, discuss biological modulatory using vast literature elegans. We suggest potential interactions aminergic systems neurophysiological activity behavior.

Language: Английский

The connectome of the adult Drosophila mushroom body provides insights into function DOI Creative Commons
Feng Li, Jack Lindsey, Elizabeth C. Marin

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Dec. 14, 2020

Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory, activity regulation. Here, we identify new components MB circuit Drosophila, including visual input output neurons (MBONs) with direct connections descending neurons. We find unexpected structure sensory inputs, transfer information different modalities MBONs, modulation that dopaminergic (DANs). provide insights into circuitry used integrate outputs, between central complex inputs DANs, feedback MBONs. Our results a foundation further theoretical work.

Language: Английский

Citations

347
Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning DOI Creative Commons
Annie Handler, Thomas G.W. Graham, Raphael Cohn

et al.

Cell, Journal Year: 2019, Volume and Issue: 178(1), P. 60 - 75.e19

Published: June 1, 2019

Language: Английский

Citations

226
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit DOI
Mehrab N Modi, Yichun Shuai, Glenn Turner

et al.

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 465 - 484

Published: April 14, 2020

The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations, yet it achieves many operations common across memory systems. Recent advances have established clear framework learning and revealed the following key operations: a) pattern separation, whereby dense combinatorial representations of odors are preprocessed to generate highly specific, nonoverlapping odor patterns used learning; b) convergence, in which sensory information is funneled small set output neurons that guide behavioral actions; c) plasticity, where changing mapping input requires strong reinforcement signal, also modulated by internal state environmental context; d) modularization, consists multiple parallel traces, distinct stability flexibility exist anatomically well-defined modules within network. Cross-module interactions allow higher-order effects past experience influences future learning. Many these parallels with processes formation action selection more complex brains.

Language: Английский

Citations

172
Forgetting as a form of adaptive engram cell plasticity DOI
Tomás J. Ryan, Paul W. Frankland

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(3), P. 173 - 186

Published: Jan. 13, 2022

Language: Английский

Citations

120
Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning DOI
Jianzhi Zeng, Xuelin Li, Renzimo Zhang

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1118 - 1135.e5

Published: Jan. 26, 2023

Language: Английский

Citations

44
Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila DOI Creative Commons
Daichi Yamada, Daniel Bushey, Feng Li

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 24, 2023

Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify feedforward circuit formed between dopamine show that essential for second-order conditioning, an ethologically important form of higher-order associative The Drosophila mushroom body comprises series dopaminergic compartments, each which exhibits dynamics. We find slow stable compartment can serve as effective ‘teacher’ by instructing other faster transient compartments via single key interneuron, connectome analysis neurotransmitter prediction. This excitatory interneuron acquires enhanced response to reward-predicting odor after first-order conditioning and, upon activation, evokes release the ‘student’ compartments. These hierarchical connections explain first- long known behavioral psychologists.

Language: Английский

Citations

43
Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics DOI Creative Commons
Yoshinori Aso, Robert P. Ray, Xi Long

et al.

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Nov. 14, 2019

Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal statistical information about the world. However, molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of insect mushroom body function as parallel units associative learning, with different rates, memory decay flexibility (Aso Rubin, 2016). Here, we show that nitric oxide (NO) acts a neurotransmitter in subset dopaminergic neurons Drosophila . NO’s effects develop more slowly than those dopamine depend on soluble guanylate cyclase postsynaptic Kenyon cells. NO antagonistically dopamine; it shortens retention facilitates rapid updating memories. interplay enables memories stored local domains along cell axons be specialized for predicting value odors based only recent events. Our results provide key mechanistic insights into how established systems.

Language: Английский

Citations

134
Availability of food determines the need for sleep in memory consolidation DOI
Nitin S. Chouhan, Leslie C. Griffith, Paula Haynes

et al.

Nature, Journal Year: 2020, Volume and Issue: 589(7843), P. 582 - 585

Published: Dec. 2, 2020

Language: Английский

Citations

71
Dopamine-based mechanism for transient forgetting DOI

John Martin Sabandal,

Jacob A. Berry, Ronald L. Davis

et al.

Nature, Journal Year: 2021, Volume and Issue: 591(7850), P. 426 - 430

Published: Jan. 20, 2021

Language: Английский

Citations

58
Lateral axonal modulation is required for stimulus-specific olfactory conditioning in Drosophila DOI Creative Commons
Julia E. Manoim, Andrew M. Davidson, Shirley Weiss

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(20), P. 4438 - 4450.e5

Published: Sept. 20, 2022

Effective and stimulus-specific learning is essential for animals' survival. Two major mechanisms are known to aid stimulus specificity of associative learning. One accurate representations in neurons. The second a limited effective temporal window the reinforcing signals induce neuromodulation after sensory stimuli. However, these often imperfect preventing unspecific associations; different stimuli can be represented by overlapping populations neurons, more importantly, alone even without coincident sensory-evoked neuronal activity. Here, we report crucial neuromodulatory mechanism that counteracts both limitations thereby In Drosophila, olfactory sparsely cholinergic Kenyon cells (KCs), which receive dopaminergic input. We find KCs have numerous axo-axonic connections mediated muscarinic type-B receptor (mAChR-B). By using functional imaging optogenetic approaches, show suppress odor-evoked calcium responses dopamine-evoked cAMP neighboring KCs. Strikingly, behavior experiments demonstrate mAChR-B knockdown impairs inducing undesired changes valence an odor was not associated with reinforcer. Thus, this local acts concert sparse global modulation achieve memory formation.

Language: Английский

Citations

46